The antiviral immunity of ticks against transmitted viral pathogens.

abstract：:There is increasing concern about the possible effect of pharmaceutical compounds may have on the fish immune system. Bath exposition of 17α-ethynylestradiol (EE2), a synthetic estrogen used in oral contraceptives, altered the immune response of the gilthead seabream (Sparus aurata L.), a marine hermaphrodite teleost....

journal_title：Developmental and comparative immunology

authors： Rodenas MC,Cabas I,Abellán E,Meseguer J,Mulero V,García-Ayala A

更新日期：2015-12-01 00:00:00

abstract：:Pseudogymnoascus destructans (Pd), the causative agent of white-nose syndrome in North America, has decimated bat populations within a decade. The fungus impacts bats during hibernation when physiological functions, including immune responses, are down-regulated. Studies have shown that Pd is native to Europe, where i...

journal_title：Developmental and comparative immunology

authors： Fritze M,Puechmaille SJ,Costantini D,Fickel J,Voigt CC,Czirják GÁ

更新日期：2021-01-18 00:00:00

abstract：:Three molecular forms of immunoglobulins: pentamer, dimer and monomer, were isolated from serum of the frill shark, Chlamydoselachus anguineus, the most primitive extant shark. A pentamer having an apparent mass of 900 kDa, consisting of 68 kDa heavy (H) chains and 22-24 kDa light (L) chains, was considered to be IgM ...

journal_title：Developmental and comparative immunology

authors： Kobayashi K,Tomonaga S,Tanaka S

更新日期：1992-07-01 00:00:00

abstract：:During the last decades, gene and cDNA cloning identified TCR and Ig genes across vertebrates; genome sequencing of TCR and Ig loci in many species revealed the different organizations selected during evolution under the pressure of generating diverse repertoires of Ag receptors. By detecting clonotypes over a wide ra...

journal_title：Developmental and comparative immunology

authors： Castro R,Navelsaker S,Krasnov A,Du Pasquier L,Boudinot P

更新日期：2017-10-01 00:00:00

abstract：:A range of marine invertebrates were screened for prophenoloxidase (a marker protein of the prophenoloxidase activating system) in the coelomic fluid or hemolymph. The crustaceans and the ascidian, Ciona intestinalis, displayed strongest activity, with low levels found in the starfish, Asterias rubens, the sea urchin,...

journal_title：Developmental and comparative immunology

authors： Smith VJ,Söderhäll K

更新日期：1991-10-01 00:00:00

abstract：:Immunoglobulin heavy chain (IgH) variable (V) region cDNAs from the Atlantic salmon, Salmo salar L., have been isolated and analysed with respect to diversity and transcription of the two parallel IgH isoloci in this species. A total of nine V(H) families were defined according to the 80% identity criterion, of which ...

journal_title：Developmental and comparative immunology

authors： Solem ST,Hordvik I,Killie JA,Warr GW,Jørgensen TO

更新日期：2001-06-01 00:00:00

abstract：:Trypanosoma carassii is an extracellular parasite of economically important fish species that has evolved several strategies to circumvent host immune responses. Proteomic analysis of the excreted/secreted (ES) and surface molecules of the parasite has revealed a number of proteins that may be involved in host-parasit...

journal_title：Developmental and comparative immunology

authors： Oladiran A,Belosevic M

更新日期：2010-04-01 00:00:00

abstract：:The striking difference in evolution of type I IFN genes of fish and mammals poses the question of whether these genes are induced through similar or different signalling pathways in the two vertebrate groups. Previous work has shown that expression of both Atlantic salmon (Salmo salar) IFNa1 and mammalian IFN-beta ge...

journal_title：Developmental and comparative immunology

authors： Lauksund S,Svingerud T,Bergan V,Robertsen B

更新日期：2009-11-01 00:00:00

abstract：:Siglec-3/CD33 is a myeloid-specific inhibitory receptor that is expressed on cells of the immune system, where it is believed to play a regulatory role, modulating the inflammatory and immune responses. We characterized CD33 (RbCD33) in rock bream which is a transmembrane protein with two IG-like domains and a cytopla...

journal_title：Developmental and comparative immunology

authors： Jeswin J,Joo MS,Jeong JM,Bae JS,Choi KM,Cho DH,Park SI,Park CI

更新日期：2018-07-01 00:00:00

abstract：:Tick defensins are antimicrobial peptides that play a major role in the innate immunity of ticks by providing a direct antimicrobial defense. In this study, we identified and characterized a defensin-like encoding gene, HEdefensin, from the expressed sequence tags (EST) database of hemolymph from the hard tick Haemaph...

journal_title：Developmental and comparative immunology

authors： Talactac MR,Yada Y,Yoshii K,Hernandez EP,Kusakisako K,Maeda H,Galay RL,Fujisaki K,Mochizuki M,Tanaka T

更新日期：2017-03-01 00:00:00

abstract：:Dicer (Dcr) is the key protein of the RNA interference (RNAi) pathway. To investigate the role of the RNAi pathway in shrimp anti-viral immunity, Litopenaeus vannamei Dcr2 (designated as LvDcr2) was identified and characterized. The full-length cDNA of LvDcr2 was 5513bp long, with an open reading frame encoding a puta...

journal_title：Developmental and comparative immunology

authors： Chen YH,Jia XT,Zhao L,Li CZ,Zhang S,Chen YG,Weng SP,He JG

更新日期：2011-06-01 00:00:00

abstract：:The intestinal immune system in Gallus species must rapidly adapt to the omnivorous onset of an adult diet and to colonization by commensal bacteria. Yet, acquired immune functions in Gallus digestive tract fully develop only towards the end of the first week post-hatch. This raises the question of immune protection i...

journal_title：Developmental and comparative immunology

authors： Bar-Shira E,Friedman A

更新日期：2006-01-01 00:00:00

abstract：:Dipteran insects, like mosquitoes, possess more than two prophenoloxidase (PPO) genes, but it is unclear whether their gene products differ in biochemical properties and physiological functions. Here, we used three Drosophila melanogaster PPOs as models to study their properties through expression in S2 cells. Our dat...

journal_title：Developmental and comparative immunology

authors： Liu F,Chen Y,Yang B,Wang J,Peng Q,Shao Q,Li X,Beerntsen BT,Xu Y,Li J,Yu XQ,Ling E

更新日期：2012-03-01 00:00:00

abstract：:Serine protease inhibitors (SPIs) play a key role in physiological responses by controlling protease activities. In this study, we studied the biochemical functions of serpin-15, an SPI, from Bombyx mori (Bmserpin-15). Recombinant Bmserpin-15 was expressed in Escherichia coli cells and used to raise rabbit anti-Bmserp...

journal_title：Developmental and comparative immunology

authors： Liu D,Wang L,Yang L,Qian C,Wei G,Dai L,Li J,Zhu B,Liu C

更新日期：2015-07-01 00:00:00

abstract：:Ovotransferrin (OTF) is an acute phase protein in chickens, serum levels of which increase in inflammation and infections. To understand the significance of OTF in inflammation, we studied its in vitro effects on HD11 cells, a macrophage cell line, and heterophils isolated from blood using a panel of variables indicat...

journal_title：Developmental and comparative immunology

authors： Xie H,Huff GR,Huff WE,Balog JM,Rath NC

更新日期：2002-11-01 00:00:00

abstract：:The major milk whey proteins of the tammar wallaby (Macropus eugenii) have been identified over the total period of lactation using proteomic analysis techniques comprising two-dimensional electrophoresis, comparative image analysis, matrix assisted laser desorption ionisation mass spectrometry (MALDI MS), de novo pep...

journal_title：Developmental and comparative immunology

authors： Joss JL,Molloy MP,Hinds L,Deane E

更新日期：2009-02-01 00:00:00

abstract：:Individual adult channel catfish were immunized by immersion in an antigen bath containing dinitrophenylated-horse serum albumin. Anti-DNP hemagglutination titers of serum and cutaneous mucus were determined following both primary and secondary bath immunization. The results showed that five of the six fish had a cuta...

journal_title：Developmental and comparative immunology

authors： Lobb CJ

更新日期：1987-10-01 00:00:00

abstract：:Early activation and coordination of innate defenses are critical for effective responses against infiltrating pathogens. Rapid engagement of immune cells provides a critical first line of defense soon after pathogen infiltration. Activation leads to a well-orchestrated set of events that sees the induction and regula...

journal_title：Developmental and comparative immunology

authors： Rieger AM,Barreda DR

更新日期：2011-12-01 00:00:00

abstract：:The differentiation of distinct leukocyte subsets is governed by lineage-specific growth factors that elicit disparate expression of transcription factors and markers by the developing cell populations. For example, macrophages (Mφs) and granulocytes (Grns) arise from common granulocyte-macrophage progenitors in respo...

journal_title：Developmental and comparative immunology

authors： Yaparla A,Koubourli DV,Popovic M,Grayfer L

更新日期：2020-12-01 00:00:00

abstract：:Phagocytosis is main cellular immunity, however, it is still unknown or debated upon which types of hemocyte contributes phagocytosis in penaeid shrimps. The hemocyte characterization in kuruma shrimp have been mainly performed based on its morphology by microscopic observation. Therefore, establishment of molecular m...

journal_title：Developmental and comparative immunology

authors： Koiwai K,Kondo H,Hirono I

更新日期：2018-04-01 00:00:00

abstract：:Serum amyloid A (A-SAA) has previously been reported to be an acute-phase protein in salmonids. Hepatocytes represent a major source of A-SAA in salmonids, but nothing is known about hepatocyte SAA synthesis in fish. In the present work, the expression of A-SAA transcripts in primary cultures of Atlantic salmon hepato...

journal_title：Developmental and comparative immunology

authors： Jørgensen JB,Lunde H,Jensen L,Whitehead AS,Robertsen B

更新日期：2000-09-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Developmental and comparative immunology

authors： Hu J,Shan H,Wang S,Yang P,Wang Y,Sun H,Huang J,Yang R,Zhang C,Qin X

更新日期：2012-05-15 00:00:00

abstract：:The rainbow trout caspase 6 gene has been cloned and sequenced. The open reading frame consisted of 906bp, which translated into a protein of 302 amino acids, containing the caspase active site pentapeptide (QACRG) and the caspase family signature (HADADCFVCVFLSHG). Amino acids involved in catalysis and those known to...

journal_title：Developmental and comparative immunology

authors： Laing KJ,Holland J,Bonilla S,Cunningham C,Secombes CJ

更新日期：2001-05-01 00:00:00

abstract：:Regulation of immune responses in animals is largely governed by the JAK-STAT and NF-κB pathways, which are conserved across vertebrates and invertebrates. At present, the relationship between these two pathways in invertebrates remains unclear. In the current study, a novel antimicrobial peptide termed LvSWD5 belongi...

journal_title：Developmental and comparative immunology

authors： Yang L,Luo M,Guo Z,Zuo H,Weng S,He J,Xu X

更新日期：2020-03-01 00:00:00

abstract：:The lectin pathway of the complement system has a pivotal role in the defense against infectious organisms. Mannose-binding lectin/ficolin-associated protein (MAp44), a multifunctional complement regulator, regulates the complement activation by competing with MASP-1, MASP-2 and MASP-3 for MBL and ficolin binding site...

journal_title：Developmental and comparative immunology

authors： Mu L,Wu H,Han K,Wu L,Bian X,Li B,Guo Z,Yin X,Ye J

更新日期：2019-12-01 00:00:00

abstract：:Immune checkpoint immunotherapy is a pillar of human oncology treatment with potential for non-human species. The first checkpoint immunotherapy approved for human cancers targeted the CTLA4 protein. CTLA4 can inhibit T cell activation by capturing and internalizing CD80 and CD86 from antigen presenting cells, a proce...

journal_title：Developmental and comparative immunology

authors： Wong C,Darby JM,Murphy PR,Pinfold TL,Lennard PR,Woods GM,Lyons AB,Flies AS

更新日期：2021-02-01 00:00:00

abstract：:Manganese superoxide dismutases (MnSODs) are usually mitochondrial enzymes, although there are few examples of cytosolic MnSODs (cMnSOD). We have previously characterized a cMnSOD cDNA from Litopenaeus vannamei hemocytes, and to obtain new insights into the tissue specific expression and the protein structure, we char...

journal_title：Developmental and comparative immunology

authors： Gómez-Anduro GA,Sotelo-Mundo RR,Muhlia-Almazán A,Yepiz-Plascencia G

更新日期：2007-01-01 00:00:00

abstract：:Toll-like receptors (TLRs)are pattern recognition receptors (PRRs) that are important in invertebrate innate immunity for the recognition and elimination of pathogens. Although they were reported in many fishes, Toll-like receptors subfamily contain a large number of members with different functions that need to resea...

journal_title：Developmental and comparative immunology

authors： Wu M,Zhu KC,Guo HY,Guo L,Liu B,Jiang SG,Zhang DC

更新日期：2021-04-01 00:00:00

abstract：:A cytolytic protein named Coelomic Cytolytic Factor-1 (CCF-1) was isolated from the coelomic fluid of the earthworm Eisenia foetida foetida. Despite the absence of any gene homology, CCF-1 showed functional analogy with the mammalian cytokine tumour necrosis factor (TNF), particularly based on similar lectin-like acti...

journal_title：Developmental and comparative immunology

authors： Olivares Fontt E,Beschin A,Van Dijck E,Vercruysse V,Bilej M,Lucas R,De Baetselier P,Vray B

更新日期：2002-01-01 00:00:00

abstract：:Allorecognition has been well-studied in the context of vertebrate adaptive immunity and recognition of the Major Histocompatibility Complex (MHC), which is the central event of vertebrate immune responses. Although allorecognition systems have been identified throughout the metazoa, recent results have shown that the...

journal_title：Developmental and comparative immunology

authors： Taketa DA,De Tomaso AW

更新日期：2015-01-01 00:00:00