Ancylostoma ceylanicum: ATP production and effect of anthelmintics.

Abstract:

:Dicarboxylic acids and a few amino acids were found to support mitochondrial phosphorylation in A. ceylanicum. Anaerobiasis markedly reduced this activity. Maximum effect was observed on succinate supported phosphorylation which in anaerobic atmosphere yielded only 2% ATP compared to that in the presence of air. Known as well as candidate anthelmintics significantly inhibited ATP formation. Mebendazole, amongst them, registered greatest effect. Oxygen consumption by the mitochondria exhibited poor response to the action of anthelmintics other than praziquantel.

journal_name

Indian J Exp Biol

authors

Srivastava VM,Agarwal N,Visen PK,Katiyar JC

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

578-81

issue

6

eissn

0019-5189

issn

0975-1009

journal_volume

28

pub_type

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