Antinociceptive action of Azadirachta indica (neem) in mice: possible mechanisms involved.

Abstract:

:Azadirachta indica (AI, Neem) was tested for analgesic potency in experimental pain models in mice. In the glacial acetic acid (GAA) induced writhing test, AI (10, 30 and 100 mg/kg) dose-dependently reduced both the incidence and the number of writhes. Similarly, AI, at the dose levels tested, also enhanced tail withdrawal latencies in the tail-flick test for nociception. In the interaction studies, pretreatment with the opioid antagonist, naloxone (1 mg/kg) and the central noradrenaline depleter, DSP-4 (50 mg/kg) attenuated AI analgesia by differential degrees in both experimental models, whereas, the serotonin synthesis inhibitor, PCPA (300 mg/kg) potentiated the same. These results suggest that both central and peripheral mechanisms and complex neural pathways, opioid and non-opioid, may be involved in AI induced analgesia.

journal_name

Indian J Exp Biol

authors

Khanna N,Goswami M,Sen P,Ray A

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

848-50

issue

11

eissn

0019-5189

issn

0975-1009

journal_volume

33

pub_type

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