Abstract:
:Azadirachta indica (AI, Neem) was tested for analgesic potency in experimental pain models in mice. In the glacial acetic acid (GAA) induced writhing test, AI (10, 30 and 100 mg/kg) dose-dependently reduced both the incidence and the number of writhes. Similarly, AI, at the dose levels tested, also enhanced tail withdrawal latencies in the tail-flick test for nociception. In the interaction studies, pretreatment with the opioid antagonist, naloxone (1 mg/kg) and the central noradrenaline depleter, DSP-4 (50 mg/kg) attenuated AI analgesia by differential degrees in both experimental models, whereas, the serotonin synthesis inhibitor, PCPA (300 mg/kg) potentiated the same. These results suggest that both central and peripheral mechanisms and complex neural pathways, opioid and non-opioid, may be involved in AI induced analgesia.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Khanna N,Goswami M,Sen P,Ray Asubject
Has Abstractpub_date
1995-11-01 00:00:00pages
848-50issue
11eissn
0019-5189issn
0975-1009journal_volume
33pub_type
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