Abstract：
:Preventive role of lipistat against doxorubicin induced myocardial toxicity in rats has been reported. Cardiotoxicity was produced by doxorubicin administration (15 mg/kg for 2 weeks). Lipistat (350 mg/kg, orally) was administered as pretreatment for 2 weeks and then for 2 weeks alternated with doxorubicin. The general observations, mortality, histopathology, biomarker enzymes like lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), serum lipid profiles like total cholesterol, triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL), antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were monitored after 3 weeks of last dose. Pretreatment with the lipistat significantly protected myocardium from the toxic effects of doxorubicin by reducing the elevated level of biomarker enzymes like LDH and CPK to the normal and serum lipids such as total cholesterol, triglyceride and LDL back to normal. Lipistat increases the decreased level of GSH, SOD and CAT and decreases the increased level of malondialdehyde in cardiac tissue. The repeated administration of doxorubicin causes cardiomyopathy associated with an antioxidant deficit and increased level of lipid profiles by interfering with fatty acid metabolism. The results support the lipid lowering and antioxidant properties of lipistat, which indicate the cardioprotective property against doxorubicin induced cardiotoxicity.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Koti BC,Vishwanathswamy AH,Wagawade J,Thippeswamy AHsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
41-6issue
1eissn
0019-5189issn
0975-1009journal_volume
47pub_type
杂志文章abstract：:Effects of tamoxifen (Tam) on cytosolic estradiol (E2) receptors (ERc), progesterone (P4) receptors (PRc), nuclear estradiol (ERn) and progesterone receptors (PRn) were studied in adult normal rabbit uterine tissue. The ratio of cytosol: nuclear estradiol receptors (ER) was greater in rabbits treated with Tam than E2 ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:Influence of silymarin on UDP-glucuronic acid (UDPGA) and glucuronidation activity of freshly isolated rat hepatocytes in suspension and in rat liver in vivo was examined. Viability of the hepatocytes (> 85%) was not altered in Hank's balanced salt solution at least for 4 hr at 37 degrees C under oxygen. Silymarin at ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Administration of bromocriptine (Bc), an ergot derivative having dopamine receptor agonist activity, to rats on day 1-5 of pregnancy prevented implantation of blastocysts and significantly suppressed uterine glucosamine 6-phosphate synthase activity. There was no effect on implantation or the enzyme activity when Bc w...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:The role of acetylation in the antiglycating and anticataract effects of aspirin (ASA) is explored by comparing ASA's effects with that of sodium salicylate (SS), a nonacetyl analog of ASA, on cataract development in diabetic rats. Streptozocin diabetic rats were provided with either ASA or SS, orally, for 24 weeks. A...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：:The properties of biophoton signals emitted by samples of lichen species P. tinctorum are investigated. The shape of a light induced signal is determined from 5 ms onwards using successively the bin resolution of 1, 10 and 100 ms; 1000 measurements in successive bins are made at each resolution. The measurement of the...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:Saponins, isolated from M. butyracea, were assessed for their acute and subacute oral toxicity in albino rats. Acute doses of saponins caused mortalities and LD50 and LD90 values were 330 and 430 mg/kg body wt respectively. Severe diarrhoea, restlessness and histopathological changes were observed in liver and kidney....
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:The possibility of sperm as a vehicle to deliver foreign DNA to oocytes was tested in hamsters. Epididymal spermatozoa, incubated with linearized plasmid DNA encoding ovine growth hormone (pCMXoGH), showed a spontaneous tendency to interact with DNA. Kinetics of sperm uptake of DNA was determined by using [32P]-labele...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:Presence of angiotensin converting enzyme (ACE, EC 3.4.15.1) in female reproductive tract and its interaction with semen has been investigated in domestic fowl. Higher activity of ACE was detected in homogenates of infundibulum region followed by magnum and relatively low level was noticed in rest of the parts of the ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:In the present investigation, growth of the organisms was reduced due to presence of arsenic (III) and (V) in the culture medium. In comparison to arsenic (V), arsenic (III) had more toxic effect on microalgae. Among the different algal strains, blue green algal species Oscillatoria-Lyngbya mixed culture showed maximu...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：:The antioxidant activities of the crude hydro-alcoholic extract (CE) and its four fractions viz. methanol (MF), ethyl acetate (EF), n-Butanol (BF), and precipitated aqueous (PAF) of A.racemosus roots tested decreased in the order of EF > MF > CE > BF > PAF when investigated by DPPH free radical scavenging assay. Under...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：:In vitro effects of various organophosphate pesticides (dimethoate, chlorpyrifos, ethion and monocrotophos) were studied on hemolysis, K+ leakage and lipid peroxidation in rat erythrocytes. All the four pesticides increased hemolysis and K+ leakage from erythrocytes, that was concentration and time dependent. On the c...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:Mast cell dynamics has been studied in relation to cystogenesis of ovarian follicles in the house rat. Immature rats were injected (s.c.) daily with DHEA (6.0 mg/100 g body weight) and were sacrificed on the day 8, 16 and 24 of the start of treatment. Ovarian sections of the treated rats had majority of the antral fol...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Ovine LH is needed for differentiation of juvenile Leydig cells and for their maintenance and steroidogenic potential, while FSH is necessary for Sertoli cell activity and spermatogonial multiplication suggesting that LH is steroidogenic hormone and FSH is gametogenic in the developing pigeon, C. livia. Homoplastic pi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:In the present studies, the role of oxidative stress in radiosensitization by a combination of 2-DG and 6-aminonicotinamide (6-AN) was examined in a human glioma cell line (BMG-1: wild type p53). Presence of 2-DG or 6-AN for 4 hr after irradiation (gamma ray 2.5 Gy) significantly enhanced the radiation-induced cell de...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:The biodegradation of spent saline bottles, a low density polyethylene product (LDPE) by two selected Arthrobacter sp. under in vitro conditions is reported. Chemical and UV pretreatment play a vital role in enhancing the rate of biodegradation. Treated LDPE film exhibits a higher weight loss and density when compared...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:Chinese hamster V79 cells were repeatedly exposed to a low dose of hydrogen peroxide (H2O2) over several weeks and then exposed to H2O2, cisplatin or ultraviolet (UV) light. Cell killing was examined by colony formation, following these treatments. It was seen that cells conditioned by multiple low doses of H2O2 showe...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
abstract：:Urine samples, collected from Sprague Dawley rats treated with extracts of tobacco/masheri, benzo (a) pyrene, N'-nitrosonornicotine, N'-nitrosodiethylamine and maintained on semi-synthetic diets sufficient or deficient in Vitamin A, B and protein were tested for mutagenicity using Salmonella/microsome assay. The mutag...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:Diabetes induced by streptozotocin (50 mg/kg body wt, i.p.) in the rats substantially increased the plasma glucose and malondialdehyde levels along with corresponding decrease in the antioxidants levels. Supplementation of vitamin E (200 mg/kg body wt., ip) for 5 weeks resulted in non-significant decrease in the blood...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-02-01 00:00:00
abstract：:Getting higher yields of monoclonal antibody (MAb) is a problem in Hybridoma Technology which has two major bottlenecks--(a) poor yield of hybridized cells; and (b) low cellular productivity of MAb in culture. There are three ways of obtaining high MAb yield in vitro--(a) large scale culture of hybrid cells; (b) high ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：1998-02-01 00:00:00
abstract：:The present study on a defined deletion aroA mutant (B-26) of Salmonella enterica subspecies enterica serovar Abortusequi (S. Abortusequi) for residual virulence and safety in experimental model revealed that the virulence of the strain was at no difference in any of the cell assays (caprine alveolar macrophages, bovi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：:Five sheep were intoxicated with powdered L. camara, leaves at the rate of 200 mg/kg body weight daily for 110 days and another group of four sheep were drenched with distilled water daily for equal number of days which acted as control. The cell mediated immunity of intoxicated and control sheep was assessed with the...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:Axillary buds obtained from field grown plants of D. hamiltonii were used to initiate multiple shoots on Murashige and Skoog's medium (MS) supplemented with 2 mg L(-1) 6-benzyl aminopurine (BA) and 0.5 mg L(-1) indole-3-acetic acid (IAA). Profuse rooting was achieved when the actively growing shoots were cultured on M...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Effects of a selective monoamine oxidase (MAO)--A inhibitor, clorgyline, a selective MAO-B inhibitor, deprenyl, and a non-selective MAO inhibitor, nialamide, were investigated on footshock-induced aggression (FIA) in paired rats. The doses and pretreatment times of the inhibitors used were based on an earlier reported...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:Reduction of p-benzoquinone to hydroquinol has been studied using Saccharomyces cerevisae and S.uvarum. Maximum conversion of p-Benzoquinone (p-BQ) to Hydroquinol (HQ) at a substrate concentration of 6%. S. cerevisae was found to be better than S. uvarum. No further conversion did take place after 60 hr. Optical innoc...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The present study was undertaken to evaluate the role of propofol in altering pentylenetetrazol induced seizure threshold in rats. Total 42 Wistar rats were used to evaluate different parameters (onset of action, duration of seizure, seizure severity score and number of seizure) following propofol injection. The prese...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：:Cheek gland secretions from sexually mature and reproductively active male and female laboratory rats (Wister strain), Rattus norvegicus albinus were analysed by gas chromatography/mass spectroscopy. Alkanes, aliphatic acids esters and alcohols were identified in the secretions. Cheek gland preparation from males cont...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:Anther culture (AC) derived 160 doubled haploid (DH) families of an indica rice PTB 28 were field evaluated at Port Blair (lat 11 degrees.41'13.04"N; long 92 degrees 43'30.16"E), to assess the extent and range of induced variability among the androclones at segregating A2 generation and identify promising selectants f...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-10-01 00:00:00
abstract：:Cognitive disorders in mankind are not uncommon. Apart from neurodegenerative diseases such as Alzheimer's (AD), various stresses also affect cognitive functions. Plants are known to be potential source of compounds that ameliorate several diseases including cognitive impairment. Here, we evaluated effect of aqueous e...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2016-02-01 00:00:00
abstract：:Immobilization of cyanobacterium Spirulina platensis in sodium alginate (1.5 %) gave the best quality of bead and 15-16 beads were formed per mL of aqueous solution of alginate. The immobilized cells were used in a batch process for treatment of diluted sewage. After 8 days, 95 % of BOD5, 77 % of COD, 90 % of ammonia,...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
abstract：:Formation of strand-breaks in DNA and its repair in Yoshida ascites tumor cells exposed to gamma radiation (100-400 Gy) in presence and absence of misonidazole (10 mM) were studied. The methodology involved pre-labelling of cellular DNA by 3H-thymidine during cell proliferation in rats, irradiation of cells in vitro a...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
