Abstract:
:Saponins, isolated from M. butyracea, were assessed for their acute and subacute oral toxicity in albino rats. Acute doses of saponins caused mortalities and LD50 and LD90 values were 330 and 430 mg/kg body wt respectively. Severe diarrhoea, restlessness and histopathological changes were observed in liver and kidney. Diets containing saponins at 0,250,500 and 1000 ppm for 14 weeks did not affect food intake, growth or organ weights, but induced mild histological changes in liver and kidney and altered the serum levels of alkaline phosphatase, blood urea nitrogen, cholesterol and proteins, particularly in female rats.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Lalitha T,Vishwanatha S,Venkataraman LVsubject
Has Abstractpub_date
1990-07-01 00:00:00pages
642-7issue
7eissn
0019-5189issn
0975-1009journal_volume
28pub_type
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