Hepatoprotective effect of coumestans isolated from the leaves of Wedelia calendulacea Less. in paracetamol induced liver damage.

Abstract:

:Effect of coumestans isolated form the leaves of W. calendulacea was evaluated in paracetamol induced liver damage. The increased serum enzyme levels (lactate dehydrogenase, alanine and aspartate transaminase and alkaline phophatase) by paracetamol induction were significantly lowered due to coumestans treatment. Results of this study revealed that coumestans of W. calendulacea afforded a significant protective action in the alleviation of paracetamol induced hepatocellular injury.

journal_name

Indian J Exp Biol

authors

Emmanuel S,Amalraj T,Ignacimuthu S

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

1305-7

issue

12

eissn

0019-5189

issn

0975-1009

journal_volume

39

pub_type

杂志文章
  • Effect of nutritional status on mutagenicity of urine excreted by rats treated with standard/experimental carcinogens.

    abstract::Urine samples, collected from Sprague Dawley rats treated with extracts of tobacco/masheri, benzo (a) pyrene, N'-nitrosonornicotine, N'-nitrosodiethylamine and maintained on semi-synthetic diets sufficient or deficient in Vitamin A, B and protein were tested for mutagenicity using Salmonella/microsome assay. The mutag...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Ammigan N,Nagabhushan M,Nair UJ,Amonkar AJ,Bhide SV

    更新日期:1990-08-01 00:00:00

  • Pathogenesis of wasting disease after cyclophosphamide treatment of neonatal mice.

    abstract::Cyclophosphamide is a potent immunosuppressive agent and is being widely used in organ transplantation. The effects of this anti-rejection drug on lymphoid organs are poorly understood. Newborn Swiss mice injected with various doses of cyclophosphamide suffered from wasting disease at 4 weeks post treatment. The incid...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Bains GS,Dhake GS

    更新日期:1992-01-01 00:00:00

  • Stress and water balance: the roles of ANP, AVP and isatin.

    abstract::Stress is often associated with water retention and its resolution with diuresis. The biological systems for the control of stress and water balance are very closely related. Corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) are co-localised in the hypothalamus and often act synergistically. Atrial...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章,评审

    doi:

    authors: Bhattacharya SK,Chakrabarti A,Glover V

    更新日期:1998-12-01 00:00:00

  • Effect of a polyherbal formulation, Ambrex, on butylated hydroxy toluene (BHT) induced toxicity in rats.

    abstract::Effect of polyherbal formulation Ambrex was evaluated in butylated hydroxytoluene (BHT) induced toxicity of lungs and liver in rats. Toxicity was produced by administering BHT (500 mg/kg/day) for 3 days. Lung damage was evidenced by elevated levels of broncho alveolar lavage fluid (BAL) parameters such as protein, lac...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Devi RS,Narayan S,Mohan KV,Sabitha KE,Devi CS

    更新日期:2003-11-01 00:00:00

  • Inhibitory effect of cinnamoyl compounds against human malignant cell line.

    abstract::In the present study, anti-proliferative effects of dietary polyphenolic compounds have been observed and demonstrated the strong anticancer efficacy of curcumin (CMN), an active constituent of dietary spice (turmeric) using human leukemia cancer cell line. CMN inhibited the proliferation of K562 leukemic cells by ind...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Indap MA,Radhika S,Motiwale L,Rao KV

    更新日期:2006-03-01 00:00:00

  • Antifungal activity and mode of action of saponins from Madhuca butyracea Macb.

    abstract::The antifungal activity of saponins isolated as a byproduct from the defatted cake of M. butyracea oil seed is reported. The inhibitory concentrations against plant pathogenic fungi ranged from 500 to 2000 ppm. Maximum sensitivity to saponins was shown by Penicillium expansum. Cephalosporium acrimonium, Helminthospori...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Lalitha T,Venkataraman LV

    更新日期:1991-06-01 00:00:00

  • Endometrium--an extragonadal source of inhibin.

    abstract::Using polyclonal antibodies generated against human seminal plasma inhibin (10.5 KDa), immunocytochemical localization was carried out in paraffin embedded tissue sections of human endometrial biopsies obtained at various phases of the menstrual cycle. A positive reaction which indicated the presence of inhibin was ch...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Garde SV,Sheth AR,Zaveri BJ,Shah J,Hinduja I

    更新日期:1991-10-01 00:00:00

  • Peripheral blood based C-PCR assay for diagnosing extra-pulmonary tuberculosis.

    abstract::Extra pulmonary tuberculosis (EPTB) constitutes around 20% of all tuberculosis cases in India. Conventional methods are of limited use in diagnosing this form of the disease. Polymerase chain reaction (PCR) has emerged as a sensitive and specific tool for documenting the presence of Mycobacterium tuberculosis in clini...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Khosla R,Dwivedi A,Sarin BC,Sehajpal PK

    更新日期:2009-06-01 00:00:00

  • Influence of kynurenines in pathogenesis of cataract formation in tryptophan-deficient regimen in Wistar rats.

    abstract::L-Tryptophan (Trp) is an essential amino acid and its deficiency is involved in various pathologies. In this present investigation an attempt was made to study the role of tryptophan and its metabolites in cataract formation in wistar rats. Rats were divided and maintained in 3 groups, Group A--control; Group B--margi...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Raju TN,Kanth VR,Reddy PU

    更新日期:2007-06-01 00:00:00

  • Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials.

    abstract::The use of plants is as old as the mankind. Natural products are cheap and claimed to be safe. They are also suitable raw material for production of new synthetic agents. Rosemary (Rosmarinus officinalis Linn.) is a common household plant grown in many parts of the world. It is used for flavouring food, a beverage dri...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章,评审

    doi:

    authors: al-Sereiti MR,Abu-Amer KM,Sen P

    更新日期:1999-02-01 00:00:00

  • Effect of electropolarity treatment on activity levels of oxidative enzymes in gastrocnemius muscle of toad, Bufo melanostictus, during early stages of denervation.

    abstract::The activity levels of succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and cytochrome-C-oxidase showed a decrement whereas lactate dehydrogenase (LDH) evinced maximum activity during first 3 days of denervation. Under the impact of cathodal polarity treatment an elevation in the activity levels of these 4 en...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Sundari BU

    更新日期:1990-06-01 00:00:00

  • Limb remote ischemic post-conditioning reduces brain reperfusion injury by reversing eNOS uncoupling.

    abstract::Limb remote ischemic postconditioning (LRIP) can reduce ischemia-reperfusion injury (IRI), but its mechanisms are still unclear. We hypothesize that LRIP reduces IRI by reversing eNOS uncoupling. Focal ischemia was induced in Sprague-Dawley rats by middle cerebral artery occlusion for 2 h followed by a 24 h reperfusio...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Chen G,Yang J,Lu G,Guo J,Dou Y

    更新日期:2014-06-01 00:00:00

  • Development of endosulfan tolerant strain of an egg parasitoid Trichogramma chilonis Ishii (Hymenoptera: Trichogrammatidae).

    abstract::A strain of T. chilonis, an egg parasitoid of lepidopteran pests tolerant to the most commonly used cyclodiene insecticide--endosulfan was developed in the laboratory. Tolerance to endosulfan was induced by exposing adult parasitoids sequentially from a sub-lethal concentration (0.004%) to the field recommended concen...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Jalali SK,Singh SP,Venkatesan T,Murthy KS,Lalitha Y

    更新日期:2006-07-01 00:00:00

  • Impact of feeding ethanolic extract of root bark of Cananga odorata (Lam) on reproductive functions in male rats.

    abstract::The 50% ethanolic extract of the root bark of C. odorata administered orally at the dose of 1g/kg body weight/day for 60 days resulted in decreased epididymal sperm motility and sperm count in male albino rats. Morphological abnormalities were also observed in the sperms. The testicular glycogen, the activities of 3be...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Anitha P,Indira M

    更新日期:2006-12-01 00:00:00

  • Effect of maternal iron deficiency on GABA shunt pathway of developing rat brain.

    abstract::Iron deficiency during pregnancy and lactation (35 mg iron/kg diet) produced a significant reduction in liver nonheme iron in dams as well as in fetus and young ones. The body, liver and brain weights of fetus, new-born, and developing pups remained unaffected. However, the body weight and PCV were reduced only in 21-...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Taneja V,Mishra KP,Agarwal KN

    更新日期:1990-05-01 00:00:00

  • Phosphorus balance and prostate cancer.

    abstract::Prostatic diseases affect men over the age of 45 and increase in frequency with age so that by the eighth decade more than 90% of men have Benign Prostatic Hyperplasia, (BPH), of which some progress to Carcinoma of Prostate (CaP). CaP, the most common malignancy in men, is also the second most common cause of death in...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章,评审

    doi:

    authors: Kapur S

    更新日期:1999-07-01 00:00:00

  • A novel DNA vaccine constructed by heat shock protein 70 and melanoma antigen-encoding gene 3 against tumorigenesis.

    abstract::Melanoma antigen-encoding gene 3 (MAGE-3) is an ideal candidate for a tumor vaccine although its potency need to be increased. Heat shock proteins (HSPs) represents a potential approach for increasing the potency of DNA vaccines. In the present study, a fusion DNA vaccine composed of Mycobacterium tuberculosis HSP70 a...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Qu P,Ma JH,Zhang XM,Huang XJ,Yang XW,Yan-Fang S

    更新日期:2010-05-01 00:00:00

  • Anti-ulcer and antioxidant activity of GutGard.

    abstract::The present study was undertaken to determine the anti-ulcer and antioxidant potential of GutGard, a standardized extract of Glycyrrhiza glabra commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGard was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indo...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Mukherjee M,Bhaskaran N,Srinath R,Shivaprasad HN,Allan JJ,Shekhar D,Agarwal A

    更新日期:2010-03-01 00:00:00

  • Cellular and molecular determinants of ageing.

    abstract::The highly complex nature of the process of ageing implicates both genetic and epigenetic causative factors. A progressive failure of maintenance underlines and typifies this process. The instability of the nuclear and the mitochondrial genomes is an important determinant of ageing. Infidelity and misregulation of gen...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章,评审

    doi:

    authors: Rattan SI

    更新日期:1996-01-01 00:00:00

  • Investigations on wound healing by using amphibian skin.

    abstract::The present investigation is aimed to justify the validity of traditional practice of using the frog skin in wound healing. Studies were carried out on skin wounds from female albino rats of Wistar strain weighing 100-120 g. The wounds of standard size (5 cm2) were created in the experimental and control groups. The e...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Sai KP,Reddy PN,Babu M

    更新日期:1995-09-01 00:00:00

  • Immune response induced by Vero cell culture adapted buffalo pox virus in rabbits and buffaloes.

    abstract::The Vero cell culture adapted buffalo pox virus was found to be completely attenuated at 40th passage for rabbits as well as buffaloes since it did not produce any thermal reaction or skin lesions. It induced high level of humoral and cell mediated immune response in rabbits as well as buffaloes. The antibody titres o...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Mohanty PK,Rai A

    更新日期:1989-04-01 00:00:00

  • Neuropharmacology of amide derivatives of P-GABA.

    abstract::Three lipophilic amide derivatives of phthaloyl-GABA (P-GABA), namely gamma-phthalimido N-amyl butyramide (PGA), gamma-phthalimido-N-hexylbutyramide (PGH) and gamma-phthalimido N-phenylbutyramide (PGP), were synthesized and evaluated for their hypnotic and anticonvulsant activities in mice. Both PGA and PGH showed mod...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Habibuddin M,Pal M,Pal SP

    更新日期:1992-07-01 00:00:00

  • Behavioural effects of prenatal diazepam administration on anxiety patterns in rats.

    abstract::Diazepam (10 mg/kg, ip) treatment was given from day 13 to 20 of gestation to pregnant rats, this being the critical period for neural development in this species. The pups born were subjected to open-field exploratory behaviour, tunnel-board exploratory behaviour, elevated zero maze behaviour and social interaction t...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Singh Y,Jaiswal AK,Singh M,Bhattacharya SK

    更新日期:1996-11-01 00:00:00

  • Alterations in ambient salinity and pH lead to modulation of developmental gene expression in Microhyla ornata (Duméril and Bibron) and Xenopus laevis (Daudin).

    abstract::Naturally fertilized Microhyla ornata and Xenopus laevis embryos at dorsal lip of blastopore stage were exposed to 0.3, and 0.6% sodium chloride for high salinity treatment and dilute hydrochloric acid and sodium hydroxide for treatment with low and high pH, respectively. After treatment for different durations, embry...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Chougule B,Asashima M,Patwardhan V,Ghaskadbi S

    更新日期:2012-08-01 00:00:00

  • Protection of adrenocortical activity by dietary casein in ether anaesthetized rats.

    abstract::Adrenal delta5-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) activity and serum corticosterone level were significantly higher in rats fed with 5% casein or 4% albumin diets after 1 hr of ether anaesthetic stress as compared to the controls, 5% casein and 20% casein (equivalent to 4% albumin) respectively. Eth...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Biswas NM,Chattopadhyay A,Sarkar M

    更新日期:2003-04-01 00:00:00

  • Alkaline lipase production by Citrobacter freundii IIT-BT L139.

    abstract::Around 150 lipase producing bacterial isolates were screened from the local soils enriched with oil. Citrobacrer freundii IIT-BT L139, an isolated microbial strain, produced lipase that had high activity (8.8 U/ml) at pH 9.0 and 40 degrees C. The 16S rDNA phylogenetic studies showed that Citrobacter freundii belongs t...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Gunasekaran V,Kotay SM,Das D

    更新日期:2006-06-01 00:00:00

  • Digital analysis of changes by Plasmodium vivax malaria in erythrocytes.

    abstract::Blood samples of malaria patients (n = 30), selected based on the severity of parasitemia, were divided into low (LP), medium (MP) and high (HP) parasitemia, which represent increasing levels of the disease severity. Healthy subjects (n = 10) without any history of disease were selected as a control group. By processi...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Edison M,Jeeva JB,Singh M

    更新日期:2011-01-01 00:00:00

  • Adrenergic influence of uterine muscle contractions stimulated by a glycoside from the root of Dalbergia saxatilis.

    abstract::The mechanism of uterine muscle contraction stimulated by a triterpenoid glycoside (dalsaxin) isolated from the root of D. saxatilis was investigated by in vitro methods in the rat. Dalsaxin caused a dose-related increase in uterine muscle contraction. The contraction was single and transient and was abolished by mode...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Uchendu CN,Leek BF

    更新日期:1999-04-01 00:00:00

  • Effect of petroleum ether extract from Hygrophila spinosa on hematological parameters and hepatorenal functions in mice.

    abstract::Multiple doses of H. spinosa were administered, ip once in a week for 4 weeks (20, 40 and 80 mg/kg body weight) and daily for one month (2, 4 and 8 mg/kg body weight). No alteration in biochemical parameters at low and moderate dose level of daily and low dose level of weekly treatment of petroleum ether extract was o...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Mazumdar UK,Gupta M,Maiti S

    更新日期:1996-12-01 00:00:00

  • Potential application of beta-1, 3 glucanase from an environmental isolate of Pseudomonas aeruginosa MCCB 123 in fungal DNA extraction.

    abstract::Pseudomonas aeruginosa MCCB 123 was grown in a synthetic medium for beta-1,3 glucanase production. From the culture filtrate, beta-1,3 glucanase was purified with a molecular mass of 45 kDa. The enzyme was a metallozyme as its beta-1,3 glucanase activity got inhibited by the metal chelator EDTA. Optimum pH and tempera...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Jose D,Jayesh P,Gopinath P,Mohandas A,Singh IS

    更新日期:2014-01-01 00:00:00