Abstract：
:Effects of multiple weekly (20, 40 and 80 mg/kg) and daily therapeutic (2, 4 and 8 mg/kg) ip doses of C. colebrookianum leaf extract on liver and kidney functions and hematological parameters in mice were studied. No alteration in hematological and biochemical parameters at low and moderate dose level of daily and low dose level of weekly treatment of alkaloidal extract was observed. However, alkaloidal extract at moderate dose in weekly treatment increased significantly serum alanine aminotransferase, alkaline phosphatase, nonprotein nitrogen, blood urea, plasma protein and erythrocyte sedimentation rate. High dose of alkaloidal extract increased all the above parameters of weekly treated mice including serum aspartate aminotransferase and plasma cholesterol and decreased significantly serum bilirubin and clotting time. Whereas, in high dose daily treatment erythrocyte count and hemoglobin content were increased and serum bilirubin was decreased. The present study reveals that the high dose (above 40 mg/kg body weight) of alkaloidal extract of C. colebrookianum affects liver and kidney functions and metabolism and also alters only clotting time and ESR whereas the therapeutic dose level (hypotensive action at 2 to 8 mg/kg, i.v., dose level) did not exhibit any toxic action on the above mentioned system; the toxic action may be due to overdose. Hepatorenal dysfunction and alteration of hematological parameters were noted at moderate and high dose in a dose dependent manner.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Gupta M,Mazumder UK,Das Ssubject
Has Abstractpub_date
1994-03-01 00:00:00pages
189-91issue
3eissn
0019-5189issn
0975-1009journal_volume
32pub_type
杂志文章abstract：:Anther culture (AC) derived 160 doubled haploid (DH) families of an indica rice PTB 28 were field evaluated at Port Blair (lat 11 degrees.41'13.04"N; long 92 degrees 43'30.16"E), to assess the extent and range of induced variability among the androclones at segregating A2 generation and identify promising selectants f...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-10-01 00:00:00
abstract：:Formulations (ointment, cream and gel) of aqueous extract of C. asiatica, when applied topically, thrice daily for 24 days on the open wounds in rats increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increase in collagen content and tensile strength. The treated wounds epitheli...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:A simple dot-immunobinding assay (Dot-Iba) in nitrocellulose paper was developed for the detection of specific IgG antibody to Mycobacterium tuberculosis antigen 5 and mycobacterial antigen in cerebrospinal fluid of patients with tuberculous meningitis (TBM). The assay gave 77.1% sensitivity for the detection of IgG a...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:This paper aims at studying the response of the housefly labellar chemoreceptor to stimulation by KCl. These studies are limited to testing various concentrations of KCl solutions (0.005-1 M), using the electrophysiological "tip recording" method and examining the various spike characteristics such as threshold, phasi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Growth of C. tetragonoloba suffered with increase in concentration of Pb in soil. Plant biomass declined significantly at concentrations above 60 ppm of Pb. Roots showed more pronounced impact as compared to shoots. At highest applied concentration of lead (100 ppm), fresh weight of fruits decreased by 33% and dry wei...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:Effects of weekly 8 hr advance- or delay-shifts on the circadian rhythm of plasma glucose, liver glycogen and muscle glycogen in male domestic fowls, beginning at about 3 days of age, were examined. Circadian rhythm in the aforesaid indices of carbohydrate metabolism in control birds was also studied. Blood and tissue...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:Pups (5 days old) were undernourished by separating them for 14 hr daily from their mothers for 7, 10, 13, 16 and 20 days. The undernourished rats showed significant decrease in body and brain weight, protein and nucleic acid contents at all stages of observation as compared to controls. The activities of SDH and AChE...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：:In vitro effects of various organophosphate pesticides (dimethoate, chlorpyrifos, ethion and monocrotophos) were studied on hemolysis, K+ leakage and lipid peroxidation in rat erythrocytes. All the four pesticides increased hemolysis and K+ leakage from erythrocytes, that was concentration and time dependent. On the c...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:Effect of polyherbal formulation Ambrex was evaluated in butylated hydroxytoluene (BHT) induced toxicity of lungs and liver in rats. Toxicity was produced by administering BHT (500 mg/kg/day) for 3 days. Lung damage was evidenced by elevated levels of broncho alveolar lavage fluid (BAL) parameters such as protein, lac...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:Substance P (SP) injection in the plantar region of rat hind paw caused a dose related inflammation, which reached a peak within 10 min of injection and declined after 60 min. Low doses (0.25-0.063 mg/kg) of SP-antagonists like (D-Pro2, D-Trp7,9)-SP and (D-Pro2, D-Phe7, D-Trp9)-SP pretreatment significantly inhibited ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Present investigation was undertaken to evaluate antihyperglycemic, antihyperlipidemic and antioxidant activities of Dihar, a polyherbal formulation containing drugs from eight different herbs viz., Syzygium cumini, Momordica charantia, Emblica officinalis, Gymnema sylvestre, Enicostemma littorale, Azadirachta indica,...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：:The present study was undertaken to identify the receptor for dengue virus type 2 (DV) induced macrophage cytotoxin (CF2) on mouse peritoneal macrophages (MPhi). The binding of 125I-labelled CF2 to MPhi was saturable (15 nM), reversible, temperature, pH- and time-dependent. The saturation concentration was similar to ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:Present study was carried out in order to explore the ability of a bone graft-decalcified as well as fluoridated to form new bone when put in the rectus abdominis muscle of rabbit. A total of 66 implants placed inside the pouches created in rectus abdominis muscle of rabbits were followed for 2 to 20 weeks. Radiologic...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:The present study on a defined deletion aroA mutant (B-26) of Salmonella enterica subspecies enterica serovar Abortusequi (S. Abortusequi) for residual virulence and safety in experimental model revealed that the virulence of the strain was at no difference in any of the cell assays (caprine alveolar macrophages, bovi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：:To evaluate the cardioprotective potential of Inula racemosa in myocardial ischemic-reperfusion injury, Wistar male albino rats were randomly divided into four groups. The group I and II animals were administered saline orally {(sham, ischemia- reperfusion (I-R) control group)} and animals of group III and group IV re...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:The present study was designed to test the hypothesis that addition of anticaspase cocktails (inhibiting caspases and thus blocking apoptosis) to the extenders increases the post-thaw viability of equine spermatozoa. The addition of caspase inhibitors failed to improve the acrosome and plasma membrane integrity of spe...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：:Thiram was administered to male rats through gavage at doses 5, 10 and 25 mg/kg/day for 180 and 360 days. Thiram has caused marginal increase in the relative weight of testes and epididymis and decrease in the weight of seminal vesicle and prostate. Marked degenerative changes were observed in seminiferous tubules tog...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：:Intramuscular injection of 3-[p-(N-2-pyrimidylsulfamoyl)phenylhydrazono]pentane-2,4-dio ne (compound I) resulted in decrease in haemoglobin and alanine transaminase (ALT) and increase in aspartate transaminase (AST) values in albino rats. The serum glucose was found to decrease and after administration of 14 doses of ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:The whole seed extract of S. nux vomica (in low doses) effectively neutralized Daboia russelii venom induced lethal, haemorrhage, defibrinogenating, PLA2 enzyme activity and Naja kaouthia venom induced lethal, cardiotoxic, neurotoxic, PLA2 enzyme activity. The seed extract potentiated polyvalent snake venom antiserum ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：:Pulp and paper mill effluents pollute water, air and soil, causing a major threat to the environment. Several methods have been attempted by various researchers throughout the world for the removal of colour from pulp and paper mill effluents. The biological colour removal process uses several classes of microorganism...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2003-11-01 00:00:00
abstract：:Mechanism of radioprotective action of caffeine by studying the gamma radiation -induced killing of yeast, S. cerevisae is reported. The results reveal that caffeine specifically protects aerobically (oxic) grown cells from gamma - radiation and sensitizes anaerobically (hypoxic) grown cells to some extent. Using radi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:Pseudomonas aeruginosa is one of the commonest pathogens among the pseudomonads. This organism can grow in minimal nutritional requirements. Because of the ability of pseudomonads to grow on paraffin is not commonly found among other human pathogens and the primary human pathogen being P. aeruginosa, we studied the ad...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2007-03-01 00:00:00
abstract：:Alzheimer’s disease (AD) is a well known progressive neurodegenerative disorder having complex pathophysiology. Currently, drugs that are used symptomatically in the treatment of AD include acetylcholinesterase inhibitors (AChEIs) (rivastigmine, galantamine, donepezil) and N-methyl D-aspartate (NMDA) receptor antagoni...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2017-02-01 00:00:00
abstract：:The xanthine oxidoreductase (XOR) system which consists of xanthine dehydrogenase (XDH) and xathine oxidase (XO), is one of the major sources of free radicals in biological systems. The XOR system is pre-dominantly present as XDH in normal tissues and converts into the free radical generating XO-form in the damaged ti...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2003-02-01 00:00:00
abstract：:Estrogenic and antiestrogenic properties of E-492, a nonsteroidal compound (3 methyl-4'-(beta-pyrrolidinoethoxy)-2,3-diphenyl propiophenone), were assessed on the basis of ponderal, histologic, and biochemical changes in the uterus, cervix, and vagina of ovariectomized adult rats. This compound was studied at its max...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Novel protocols for production of multiple shoot-tip clumps and somatic embryos of Sorghum bicolor (L.) Moench were developed with long-term goal of crop improvement through genetic transformation. Multiple shoot-tip clumps were developed in vitro from shoot-tip explant of one-week old seedling, cultured on MS medium ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:Feeding calculi producing diet (CPD) to rats for 4 weeks produced calcium oxaltate stones. Supplementation of sodium citrate to CPD (c-CPD) prevented stone formation. Except oxalate, the excretion of calcium, phosphorus and magnesium was restored to normal in c-CPD fed rats. The CPD fed rats exhibited increase in glyc...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:Parathyroid hormone (PTH), calcitonin (CT)and calciferol (Vit. D3) operate synchronously to maintain a balance between calcium and phosphate levels in serum. An aberration of specific steps in the homeostatic process results in hypo/hyper phosphatemia. These aberrations may eventually lead to several diseased states. ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Mowrah (M. latifolia) seeds yield 40-50% edible fat and the meal contains saponins besides protein and high level of carbohydrates. The toxicity of the meal was evaluated as it has a potential for use in animal feedstuffs. The meal was fed to young and adult rats at levels of 10 to 40% in diet. The animals showed mark...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Fluorescent pseudomonads were isolated from the rhizosphere of rice and sugarcane and examined for their biodiversity. All fifty strains of the fluorescent pseudomonads produced indole acetic acid. Among these pseudomonads, halves of sugarcane rhizosphere isolates and one isolate from the rice rhizosphere exhibited ph...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
