Abstract:
:Substance P (SP) injection in the plantar region of rat hind paw caused a dose related inflammation, which reached a peak within 10 min of injection and declined after 60 min. Low doses (0.25-0.063 mg/kg) of SP-antagonists like (D-Pro2, D-Trp7,9)-SP and (D-Pro2, D-Phe7, D-Trp9)-SP pretreatment significantly inhibited the SP induced paw oedema, while higher doses (0.5-1 mg/kg) showed agonistic effects. Pretreatment with diphenhydramine alone or along with low doses of SP-antagonists was highly significant in blocking this inflammation, the latter combination being more effective than the former. Pretreatment with acute capsaicin produced a synergestic effect on SP induced paw oedema, while pretreatment with chronic capsaicin significantly inhibited this SP induced paw oedema. The results indicate involvement of histamine and possible therapeutic importance of capsaicin in SP mediated inflammatory type of responses.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
De AK,Ghosh JJsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
946-8issue
10eissn
0019-5189issn
0975-1009journal_volume
28pub_type
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
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journal_title:Indian journal of experimental biology
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更新日期:1996-04-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00