Potentiation of hypoglycemic response of glibenclamide by piroxicam in rats and humans.

Abstract:

:Influence of piroxicam (PX) on glibenclamide (GL) induced hypoglycemia has been studied in rats, healthy human volunteers and diabetics. GL per se has significantly reduced blood sugar levels in rats and in humans. PX per se has significantly reduced BSLs, in diabetics, while having no significant influence on blood sugar level in rats and healthy human volunteers. Prior administration of PX has potentiated the hypoglycemic effect of GL in rats, healthy human volunteers and diabetics. GL, PX + GL administration have also significantly influenced the glucose tolerance test (GTT) in healthy human volunteers.

journal_name

Indian J Exp Biol

authors

Diwan PV,Sastry MS,Satyanarayana NV

keywords:

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

317-9

issue

4

eissn

0019-5189

issn

0975-1009

journal_volume

30

pub_type

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