Abstract:
:FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, trans-cinnamic acid, 4-formyl cinnamic acid, naringenin and caffeic acid were were tested for their potential to inhibit cell division. Effect of these antimicrobial compounds on the growth of E. coli was determined and the inhibition of FtsZ assembly in vitro was investigated. The present study revealed trans-cinnamic acid as the most potent inhibitor of FtsZ assembly.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Rastogi N,Domadia P,Shetty S,Dasgupta Dsubject
Has Abstractpub_date
2008-11-01 00:00:00pages
783-7issue
11eissn
0019-5189issn
0975-1009journal_volume
46pub_type
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