Screening of natural phenolic compounds for potential to inhibit bacterial cell division protein FtsZ.

Abstract:

:FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, trans-cinnamic acid, 4-formyl cinnamic acid, naringenin and caffeic acid were were tested for their potential to inhibit cell division. Effect of these antimicrobial compounds on the growth of E. coli was determined and the inhibition of FtsZ assembly in vitro was investigated. The present study revealed trans-cinnamic acid as the most potent inhibitor of FtsZ assembly.

journal_name

Indian J Exp Biol

authors

Rastogi N,Domadia P,Shetty S,Dasgupta D

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

783-7

issue

11

eissn

0019-5189

issn

0975-1009

journal_volume

46

pub_type

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