Abstract：
:The permeability of the cornea to drugs is clinically important because it is the major factor determining the efficacy of topically applied ophthalmic preparations. With this perspective, the present article gives a brief update and overview of corneal structure and proposed mechanisms of permeation. Physiological, physicochemical and formulation factors affecting drug permeation through cornea are highlighted. Influence of ocular penetration enhancers on drug permeation is also discussed.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Malhotra M,Majumdar DKkeywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
11-24issue
1eissn
0019-5189issn
0975-1009journal_volume
39pub_type
杂志文章,评审abstract：:Significant reduction (68.38%) in sheath blight disease of rice was noticed when foliar spray of a systemic fungicide, kitazin (480 micrograms mg-1), was applied twice at an interval of 2 days before inoculation. SDS-PAGE analysis of proteins of Rhizoctonia-infected rice leaf sheaths revealed the presence of 16 protei...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：:Around 150 lipase producing bacterial isolates were screened from the local soils enriched with oil. Citrobacrer freundii IIT-BT L139, an isolated microbial strain, produced lipase that had high activity (8.8 U/ml) at pH 9.0 and 40 degrees C. The 16S rDNA phylogenetic studies showed that Citrobacter freundii belongs t...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：:Substance P (SP) injection in the plantar region of rat hind paw caused a dose related inflammation, which reached a peak within 10 min of injection and declined after 60 min. Low doses (0.25-0.063 mg/kg) of SP-antagonists like (D-Pro2, D-Trp7,9)-SP and (D-Pro2, D-Phe7, D-Trp9)-SP pretreatment significantly inhibited ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Anther culture (AC) derived 160 doubled haploid (DH) families of an indica rice PTB 28 were field evaluated at Port Blair (lat 11 degrees.41'13.04"N; long 92 degrees 43'30.16"E), to assess the extent and range of induced variability among the androclones at segregating A2 generation and identify promising selectants f...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-10-01 00:00:00
abstract：:The mechanism of Agrobacterium mediated genetic transformation of plants is dependent upon certain genetic function of the chromosome of the bacterium as well as on Ti-plasmid borne vir loci and the border sequences of T-DNA. The organisationally variable forms of the naturally occurring border sequences amongst Ti-pl...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective loss of dopamine (DA) neurons of the substantia nigra pars compacta (SNc). The events, which trigger and/or mediate the loss of nigral DA neurons, however, remain unclear. Neuroleptic-induced catalepsy has long been used as an anima...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:The neutral detergent fiber (NDF) isolated from coconut kernel was digested with cellulase and hemicellulase and the residual fiber rich in hemicellulose (without cellulose) and cellulose (with out hemicellulose) were fed to rats and compared with a fiber free group. The results indicate that hemicellulose rich fiber ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：:Wheat peptides (0.5 to 3 KDa M(r)) mimick hormonal activity like that of gibberellins and forced open dark closed stomata. The deionized amphoteric peptides solution after passing through cation and anion exchanger resins was run through Amicon's ultrafilters, 10, 3 and 0.5 kDa (M(r)) cut off system. The 3 to 0.5 kDa ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Infrared spectra of normal and malignant breast tissues were measured in the 600 cm(-1) to 4000 cm(-1) region. The measured spectroscopic features which are the spectroscopic fingerprints of the tissues contain the vital information about the malignant and normal tissues. Fourier Transform Infrared (FTIR) data on 25 c...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:During reproductive life in the female, there is a continuous flow of growth, maturation and demise of ovarian follicles, unless pregnancy occurs. Although ovarian function is primarily controlled by the hypothalamus-pituitary-axis, there is no doubt that a hormonal microenvironment specific for each individual follic...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2003-07-01 00:00:00
abstract：:Axillary buds obtained from field grown plants of D. hamiltonii were used to initiate multiple shoots on Murashige and Skoog's medium (MS) supplemented with 2 mg L(-1) 6-benzyl aminopurine (BA) and 0.5 mg L(-1) indole-3-acetic acid (IAA). Profuse rooting was achieved when the actively growing shoots were cultured on M...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Changes in biomass yield rates, cell membrane stability (CMS), malondialdehyde (MDA) content and in the levels of physiological stress markers such as proline and glycine betaine in two high yielding genotypes (S1 and ATP, salt tolerant and salt sensitive, respectively) of mulberry under NaCl salinity were studied. Bi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-02-01 00:00:00
abstract：:Natural Killer activity assessed by 51Cr release assay from K-562 cells showed detectable activity from 5th day after tumour transplantation, reaching a peak on 12th day and thereafter showing a gradual decline in the activity. Antibody dependent cell mediated cytotoxicity estimated by 51Cr labelled sheep red blood ce...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:Efficacy of two colorimetric assays, viz. MTT (3-4,5-dimethylthiazol-2-(yl-2,5-diphenyl tetrazolium bromide) and neutral red (NR) assays, performed by integrating them to micro culture virus titration (MCVT), was compared with the conventional MCVT method in terms of percentages of infectivity and 50% infectivity end ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:Aeromonas sp. from Lamellidens marginalis produced L-asparaginase when grown at 37 degrees C. The optimum enzyme activity was at pH 9 when temperature was 45 degrees C. Half-life of partially purified enzyme at 50 degrees C and 55 degrees C was 35 and 20 min, respectively. Activation and deactivation energies of parti...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:Goat epididymal and ejaculated spermatozoa were incubated in Krebs-Ringer bicarbonate buffer containing pyruvate and lactate as energy source. A 3 hr incubation for epididymal and 4 hr for ejaculated spermatozoa was required for the capacitation and acrosome reaction to take place. Calcium is an essential requirement ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：:Cigarette smoking has been established as a major risk factor for atherosclerosis and also for lung cancer. Nicotine is one of the major components of cigarette smoke which is believed to be partly responsible for the deleterious effect of cigarette smoke. There was significant alteration in the concentration of glyco...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:Frog plasma effectively hydrolysed the synthetic chromogenic substrates, H-D-Glu-Gly-Arg-p-nitroanilide (S-2444), benzoyl-Ile-Glu-Gly-Arg-p-nitroanilide (S-2222) and acetyl-Ile-Glu-Gly-Arg- p-nitroanilide (S-2423), all sensitive substrates for trypsin. Moderate hydrolytic activities was observed with H-D-Phe-Pip-Arg-p...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：:Mouse liver was exposed in vivo to a continuous and unfocussed ultrasound of 875 KHz at 5, 10 or 15 W/cm2 for 300 sec spread over five days and excised on day 0, 1, 5 and 10 for studying the changes in Na+ and K+ reserves and Na-K-ATPase activity. At 5 and 10 W intensities the change in ionic concentrations and Na-K-A...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:The Vero cell culture adapted buffalo pox virus was found to be completely attenuated at 40th passage for rabbits as well as buffaloes since it did not produce any thermal reaction or skin lesions. It induced high level of humoral and cell mediated immune response in rabbits as well as buffaloes. The antibody titres o...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:Fluorescent pseudomonads were isolated from the rhizosphere of rice and sugarcane and examined for their biodiversity. All fifty strains of the fluorescent pseudomonads produced indole acetic acid. Among these pseudomonads, halves of sugarcane rhizosphere isolates and one isolate from the rice rhizosphere exhibited ph...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Molecular oxygen, a diradical, needs intervention of redox metal ions or other radicals to receive electrons for its reduction. The oxygen radicals thus produced are responsible for oxygen toxicity and oxidative stress. But, autoxidation, relevant in ischemia-reperfusion injury, is absent in any discussion on oxygen t...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2016-11-01 00:00:00
abstract：:Using polyclonal antibodies generated against human seminal plasma inhibin (10.5 KDa), immunocytochemical localization was carried out in paraffin embedded tissue sections of human endometrial biopsies obtained at various phases of the menstrual cycle. A positive reaction which indicated the presence of inhibin was ch...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Doses of titanium trichloride (1/10th and 1/5th of LD50) were administered once and daily to pregnant rats to assess their effect on embryonic development. 1/5th dose of TiCl3 administered once orally on 1st, 2nd and 3rd day post-coitum. Similarly 1/10th of LD50 was administered daily. Results revealed that 1/10th LD5...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:To study antimicrobial activity of shallot in comparison with that of garlic and onion against 23 strains of fungi and bacteria, water extracts of garlic, shallot and onion bulbs were prepared. Each extract was studied in different forms for their antimicrobial activity viz., fresh extract, dry extract and autoclaved ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
abstract：:A bench-scale biotrickling filter was operated in the laboratory for the treatment of dimethyl sulphide (DMS). The biotrickling filter was packed with pre-sterilized polyurethane foam and seeded with biomass developed from garden soil enriched with DMS. The biotrickling filter was operated for the generation of proces...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
abstract：:Photons participate in many atomic and molecular interactions and processes. Recent biophysical research has discovered an ultraweak radiation in biological tissues. It is now recognized that plants, animal and human cells emit this very weak biophotonic emission which can be readily measured with a sensitive photomul...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2008-05-01 00:00:00
abstract：:Acute single dose administration of lanthanum chloride (250 mg/kg body wt, ip) to chicks have been found to alter the levels of enzymes of the antioxidant defence system of chick renal cortex fractions. Such changes involved significant decrease in activities of glucose-6-phosphate dehydrogenase, glutathione reductase...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Low cost agro-waste was used as adsorption support for single-step purification of endoglucanase from the culture filtrate of A. fumigatus ABK-9. Among various agro-waste substrates, 1% NaOH pretreated rice bran was proved to be the best for adsorbing about 74.8 and 71.1% of endoglucanase at 4 degrees C and 10 degrees...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
abstract：:This paper aims at studying the response of the housefly labellar chemoreceptor to stimulation by KCl. These studies are limited to testing various concentrations of KCl solutions (0.005-1 M), using the electrophysiological "tip recording" method and examining the various spike characteristics such as threshold, phasi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
