Abstract：
:Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective loss of dopamine (DA) neurons of the substantia nigra pars compacta (SNc). The events, which trigger and/or mediate the loss of nigral DA neurons, however, remain unclear. Neuroleptic-induced catalepsy has long been used as an animal model for screening drugs for Parkinsonism. Administration of haloperidol (1 mg/kg, ip) or reserpine (2 mg/kg, ip) significantly induced catalepsy in mice. BR-16A (50 and 100 mg/kg, po), a polyherbal formulation or ashwagandha (50 and 100 mg/kg, po), significantly reversed the haloperidol or reserpine-induced catalepsy. The results indicate that BR-16A or ashwagandha has protective effect against haloperidol or reserpine-induced catalepsy and provide hope that BR-16A could be used in preventing the drug-induced extrapyramidal side effects and may offer a new therapeutic approach to the treatment of Parkinson's disease.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Kumar A,Kulkarni SKkeywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
45-8issue
1eissn
0019-5189issn
0975-1009journal_volume
44pub_type
杂志文章abstract：:Methanolic extract of P. amarus was found to have potential anti-oxidant activity as it could inhibit lipid peroxidation, and scavenge hydroxyl and superoxide radicals in vitro. The amount required for 50% inhibition of lipid peroxide formation was 104 microg/ml and the concentrations needed to scavenge hydroxyl and s...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：:Concentrations of mono- and divalent cations in the testis, three different regions of the epididymis and the vas deferens of lizard, M. carinata were determined. The concentrations of Na+, K+ and Ca2+ increased gradually from testis to vas deferens. However, no significant variation in the levels of Mg2+ was observed...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：:Initially a dose-response curve of phenylephrine was constructed at dose strengths of 1-16 microg/kg in a cumulative manner. Phenylephrine caused a significant rise in the mean arterial pressure, left ventricular systolic pressure, left ventricular contractility, stroke volume and a significant decline in the heart ra...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：:Erythrocyte structure was studied in rat after uranyl nitrate (UN:5 mg/kg) intoxication. The study of pathogenic progression of UN induced renal failure (ARF) was confined to the early initiation phase (2 hr), late initiation phase (8 hr) and the maintenance phase (24 hr). Erythrocyte structure has been found to be gr...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:The effect of the administration of three different concentrations (2.25, 1.13 and 0.56 mg/100 g body weight) of dimethoate on the urinary excretion of total, non dialysable and free hydroxyproline were studied in female albino rats. Compared to controls, the urine contents were significantly lower in higher concentra...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:With respect to 31 different selected test bacteria, all sensitive to benzyl penicillin (Pc), ampicillin (Ap), methicillin (Me), ceporan (Ce), cloxacillin (Cx), streptomycin (Sm), kanamycin (Km), gentamicin (Gm), chloramphenicol (Cm), tetracycline (Tc), polymyxin (Pm) as well as ambodryl [Am; an antihistamine (bromodi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:Limb remote ischemic postconditioning (LRIP) can reduce ischemia-reperfusion injury (IRI), but its mechanisms are still unclear. We hypothesize that LRIP reduces IRI by reversing eNOS uncoupling. Focal ischemia was induced in Sprague-Dawley rats by middle cerebral artery occlusion for 2 h followed by a 24 h reperfusio...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：:Influence of silymarin on UDP-glucuronic acid (UDPGA) and glucuronidation activity of freshly isolated rat hepatocytes in suspension and in rat liver in vivo was examined. Viability of the hepatocytes (> 85%) was not altered in Hank's balanced salt solution at least for 4 hr at 37 degrees C under oxygen. Silymarin at ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Anticancer potential of Moringa oleifera L. extracts have been well established. However, there are no reports on the isolated molecules/fractions from these extracts which are responsible for the anticancer/cytotoxic activity. Thus, in the present study, we explored the same. The n-hexane, chloroform, ethyl acetate, ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
abstract：:Breast cancer susceptibility gene (BRCA1) is known to be responsible for hereditary breast and ovarian cancer. This gene is highly penetrant conferring a risk for 0.92 by the age of 70. Germline mutation in this gene leads to susceptibility to breast and ovarian cancer, with a genotype phenotype correlation. Frequency...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2001-05-01 00:00:00
abstract：:Staphylococcus sp. strain BP/SU1, capable of degrading the biopolymer and utilize it as a source of carbon and energy, was isolated from activated sludge using METABOLIX (MBX D411G). It was found that this strain was capable of accumulating poly(3-hydroxybutyric acid) P(3-HB), as granule poly (3-hydroxybutyric acid), ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2009-04-01 00:00:00
abstract：:Urokinase-type plasminogen activator(uPA) assayed in uteri of cycling and deciduoma bearing rats shows detectable levels of this enzyme in endometrium. Zymographic analysis confirms uPA of decidual tissue and, following artificial induction of decidualisation, uPA activity constantly increases in the decidualising end...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptozotocin induced diabetic rats for 30 days significantly reduced the elevated levels of blood glucose, lipids, plasma insulin and improved altered levels of lipid peroxidation products (TBARS and hydroperoxides) and antioxid...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Here, we investigated the quantitative and qualitative differences in antibody classes and subclasses in serum immune complexes (ICs) of Visceral Leishmaniasis (VL), Post Kala-azar Dermal Leishmaniasis (PKDL) and different cross reactive diseases like Malaria, Leprosy, Vitiligo as compared to control subjects. IC leve...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2015-06-01 00:00:00
abstract：:In presence of 7.5 microM of curcumin, no embryos or larva of zebrafish survived 3 days of incubation; however, coincubation with 144 microg/ml silymarin increased the survival rates of curcumin-treated embryos and larvae to about 70%. Moreover, in presence of 12.5 microM curcumin, all embryos died after 2 days of inc...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：:Rest-activity rhythm and quality of life (QoL) in three cohorts, namely (1) cancer in-patients, (2) out-patients, and (3) control subjects were studied. The patients of the former two groups were chosen randomly from the Regional Cancer Center, Raipur, India. All patients received chemotherapy for 3-4 consecutive days...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：:Leydig cells are the primary source of androgens in the mammalian testis. It is established that the luteinizing hormone (LH) produced by the anterior pituitary is required to maintain the structure and function of the Leydig cells in the postnatal testis. Until recent years, a role by the thyroid hormones on Leydig c...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2005-11-01 00:00:00
abstract：:Progesterone, primarily recognized as a female steroid hormone, is reported to affect several sperm functions especially capacitation, motility and acrosome reaction. These effects of progesterone on the spermatozoa are mediated via the progesterone binding sites/progesterone receptor (PR) on the acrosomal membrane. T...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2003-07-01 00:00:00
abstract：:Chinese hamster V79 cells were repeatedly exposed to a low dose of hydrogen peroxide (H2O2) over several weeks and then exposed to H2O2, cisplatin or ultraviolet (UV) light. Cell killing was examined by colony formation, following these treatments. It was seen that cells conditioned by multiple low doses of H2O2 showe...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
abstract：:Dicarboxylic acids and a few amino acids were found to support mitochondrial phosphorylation in A. ceylanicum. Anaerobiasis markedly reduced this activity. Maximum effect was observed on succinate supported phosphorylation which in anaerobic atmosphere yielded only 2% ATP compared to that in the presence of air. Known...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Nine halophilic archaea viz., Halobacterium salinarum, Halobacterium sp.1, Halobacterium sp.2, Halobaculum sp., Halococcus saccharolyticus, Halorubrum saccharovorum, Haloterrigena turkmenica, Halogeometricum sp. and Natrialba sp. isolated from marine salterns around Bhavnagar coast were screened for siderophore produc...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：:Effects of weekly 8 hr advance- or delay-shifts on the circadian rhythm of plasma glucose, liver glycogen and muscle glycogen in male domestic fowls, beginning at about 3 days of age, were examined. Circadian rhythm in the aforesaid indices of carbohydrate metabolism in control birds was also studied. Blood and tissue...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:The present study was undertaken to determine the anti-ulcer and antioxidant potential of GutGard, a standardized extract of Glycyrrhiza glabra commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGard was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indo...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:Chronic (2 h/d x 8 weeks) exposure to magnetic field (MF; 50 Hz, 17.9 microT) in complete spinal cord (T13) transected rats restored food intake (FI), water intake (WI) and body weight (BW) which were decreased in the spinal cord injured rats. The results suggest a significant beneficial effect of chronic exposure to ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
abstract：:Leaves of P. sativum the double mutant genotype tendril-less (tl) leaflet-development (lld), due to the action of lld mutation, produce many leaflets that are aborted at different stages of development. Morphological, vein pattern and histological observations showed that aborted leaflets became cup/bell/trumpet (cup)...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2013-06-01 00:00:00
abstract：:Effect of Swerchirin (1:8 dihydroxy 3:5 dimethoxy xanthone) isolated from hexane fraction of Swertia chirayita on the blood sugar level of healthy and streptozotocin treated rats was studied. Streptozotocin was administered in citrate buffer (pH-4.5) intravenously / 35 and 65 mg/kg body wt to Charles Foster strain alb...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:Fluorescent pseudomonads were isolated from the rhizosphere of rice and sugarcane and examined for their biodiversity. All fifty strains of the fluorescent pseudomonads produced indole acetic acid. Among these pseudomonads, halves of sugarcane rhizosphere isolates and one isolate from the rice rhizosphere exhibited ph...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Indian toad (Bufo melanostictus, Schneider) skin extract (TSE) is pharmacologically potent and probably contains several bioactive compounds [Das et. al., Indian J Pharmacol, 28 (1996) 72]. A lethal factor was isolated and purified by neutral alumina column chromatography followed by HPLC. Spectroscopic (UV, IR, FAB-M...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
abstract：:Isoproturon, a nonhalogenated substituted phenylurea herbicide, was evaluated for its cumulative toxic effects on testicular histomorphology., steroid hormone biosynthesis-related enzymes, spermatogenesis and sperm cells in adult albino rats. The compound, suspended in refined groundnut oil, was administered (po) to r...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：:Valeriana officinalis is an important medicinal herb commonly found in Kashmir valley. This study forms an important preliminary step for in-vitro micro propagation of V. officinalis from breaking the seed dormancy, inducing rapid seed germination and its subsequent micro propagation. We investigated the influence of ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
