Abstract:
:Breast cancer susceptibility gene (BRCA1) is known to be responsible for hereditary breast and ovarian cancer. This gene is highly penetrant conferring a risk for 0.92 by the age of 70. Germline mutation in this gene leads to susceptibility to breast and ovarian cancer, with a genotype phenotype correlation. Frequency of mutations of this gene in normal population of breast cancer is low suggesting that the effort of primary screening for BRCA1 gene should be restricted to only familial cases with a strong history of breast and ovarian cancer. Recent studies indicate that BRCA1 is a tumor suppressor gene responsible for both normal development and carcinogenesis of the breast. Normal function elucidated so far, reveal BRCA1 to be a multifunctional protein involved in DNA repair, cell cycle regulation and transcription. There is circumstantial evidence that gene interacts with p53, a protein involved in cell cycle control, DNA repair and apoptosis.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Kachhap SK,Ghosh SNkeywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
391-400issue
5eissn
0019-5189issn
0975-1009journal_volume
39pub_type
杂志文章,评审abstract::Cimetidine has been demonstrated to impair microsomal oxidative drug metabolizing and other enzyme systems in mouse liver. The inhibition is rapid, occurring after a single administration and also found to be dose-dependent. It is more significant after daily administration for 15 days. Enzyme inhibition by ranitidine...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::Radiosensitizing effects of combination of a minor groove DNA ligand, Hoechst-33342, with the glucose analogue and inhibitor of glycolysis, 2-deoxy-D-glucose (2-DG) have been investigated in Ehrlich ascites tumour (EAT) bearing mice following focal irradiation of the tumour with 60Co gamma-rays. Treatment-induced tumo...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::Erythrocyte structure was studied in rat after uranyl nitrate (UN:5 mg/kg) intoxication. The study of pathogenic progression of UN induced renal failure (ARF) was confined to the early initiation phase (2 hr), late initiation phase (8 hr) and the maintenance phase (24 hr). Erythrocyte structure has been found to be gr...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::Self-mutilation or self-injurious behaviour is a well known behavioural disorder in humans. The proposition that this behaviour in animals is a response to chronic pain of peripheral nerve injury has been met with controversy. In the present study a pharmacological model, which produces no sensory or motor loss was us...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::Effect of coumestans isolated form the leaves of W. calendulacea was evaluated in paracetamol induced liver damage. The increased serum enzyme levels (lactate dehydrogenase, alanine and aspartate transaminase and alkaline phophatase) by paracetamol induction were significantly lowered due to coumestans treatment. Resu...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::Skin and tendon samples of male albino rat taken for analysis, on the 120th day of smoking showed that, compared to controls, the cigarette smoke exposed group showed an increase in tensile strength of both skin and tendon while extensibility of skin remained the same and that of the tendon increased. Thermal behaviou...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::The biodegradation of spent saline bottles, a low density polyethylene product (LDPE) by two selected Arthrobacter sp. under in vitro conditions is reported. Chemical and UV pretreatment play a vital role in enhancing the rate of biodegradation. Treated LDPE film exhibits a higher weight loss and density when compared...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2012-07-01 00:00:00
abstract::The fish, tilapia (Oreochromis mossambicus) of 50-60 g body weight was experimentally exposed to effluent gradients of highly alkaline pH in a sewage-fed aquaculture farm for examining the pH stress-induced responses of mortality and the stress marker enzyme succinate dehydrogenase and the non-specific alkaline phosph...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::Bovine leukemia virus (BLV), like its closest relatives human T-cell leukemia virus-I and II, contain a 'px' gene, between the 'env' gene and the 3' long terminal repeat in its genome. A monoclonal antibody prepared against a synthetic oligopeptide whose sequence was deduced from highly conserved region of 'px' gene o...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::The possibility of sperm as a vehicle to deliver foreign DNA to oocytes was tested in hamsters. Epididymal spermatozoa, incubated with linearized plasmid DNA encoding ovine growth hormone (pCMXoGH), showed a spontaneous tendency to interact with DNA. Kinetics of sperm uptake of DNA was determined by using [32P]-labele...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract::Lactobacillus acidophilus strains tested showed inhibitory activity towards Salmonella typhi, Staphylococcus aureus, Escherichia coli, Proteus vulgaris and Yersinia enterocolitica. However, wide variations in the activity of the strains were observed. Antagonistic activity of the strains exhibited high heat stability ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::Stevia rebaudiana (Bert.) Bertoni is an important medicinal plant used as noncaloric commercial sweetener. Plants regenerated with higher levels of copper sulphate in the medium exhibited enhanced activity of peroxidase and polyphenoloxidase (PPO) enzymes. Transmission electron microscopy (TEM) revealed increase in si...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2014-09-01 00:00:00
abstract::Lead (100 ppm) was given in doubly deionised water for 30 days to one group of rats. The other groups received lead along with exogenous antioxidants like vitamin E (50 IU/kg), vitamin C (800 mg/kg) or Spirulina (1500 mg/kg) in food for a similar period. Levels of lipid peroxidation products such as malondialdehyde, c...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The effect of the administration of three different concentrations (2.25, 1.13 and 0.56 mg/100 g body weight) of dimethoate on the urinary excretion of total, non dialysable and free hydroxyproline were studied in female albino rats. Compared to controls, the urine contents were significantly lower in higher concentra...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Rest-activity rhythm and quality of life (QoL) in three cohorts, namely (1) cancer in-patients, (2) out-patients, and (3) control subjects were studied. The patients of the former two groups were chosen randomly from the Regional Cancer Center, Raipur, India. All patients received chemotherapy for 3-4 consecutive days...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2014-05-01 00:00:00
abstract::Thermoactinomycetes vulgaris is a thermophilic actinomycetes growing optimally at 50 degrees C and Streptomyces albus, S. coelicolor, S. fasciculus and S. olivochromogenes are thermophilically disposed transition species of actinomycetes, which have optimum biomass at 40 degrees C. The acid/alkaline phosphatase and ac...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::Shoot tip explants of 5.chickpea varieties were evaluated for efficiency of rooting using MS basal medium (1/4, 1/2 and full strength). Maximum rooting was observed in 3 varieties when cultured in MS medium with 1/4 strength. Plantlets thus developed, were further cultured in Hoagland solution (1/4 strength) for 15-20...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::Ovine LH is needed for differentiation of juvenile Leydig cells and for their maintenance and steroidogenic potential, while FSH is necessary for Sertoli cell activity and spermatogonial multiplication suggesting that LH is steroidogenic hormone and FSH is gametogenic in the developing pigeon, C. livia. Homoplastic pi...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::A highly stable lipase from Pseudomonas aeruginosa KKA-5 was produced by batch cultivation technique employing shake flask and 5 L-bioreactor. The bioreactor was run at different airflow rates. Low airflow rates (1 and 3 L/min), did not lead to effective growth and lipase production. Growth increased by about one orde...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract::Leprosy bacillus (LB) and leprosy derived in vitro culture forms, the chemoautotrophic nocardioform (CAN) bacteria, showed an extremely close homology and identity with each other as regards a chemoautotrophic nutritional pattern, a nocardioform morphology, a weak acid-fastness coupled with Gram and Gomori's stain pos...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
doi:
更新日期:2001-10-01 00:00:00
abstract::Extra pulmonary tuberculosis (EPTB) constitutes around 20% of all tuberculosis cases in India. Conventional methods are of limited use in diagnosing this form of the disease. Polymerase chain reaction (PCR) has emerged as a sensitive and specific tool for documenting the presence of Mycobacterium tuberculosis in clini...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2009-06-01 00:00:00
abstract::A study to monitor marine pollution with reference to trace elements (Fe, Zn, Mn and Cu) on T. attenuata, commonly called as screw shell over a period of one year on the whole body and various organs, viz. digestive diverticula, foot, mantle and ovary was conducted from the sandy beach of Porto Novo Coast (Lat 11 degr...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract::Effect of feeding isolated dietary fiber from M. paradisiaca on the metabolism of carbohydrates in the liver has been studied. Fiber fed rats showed significantly lower levels of fasting blood glucose and higher concentration of liver glycogen. Activity of glycogen phosphorylase, glucose-1-phosphate, uridyl transferas...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::Wheat peptides (0.5 to 3 KDa M(r)) mimick hormonal activity like that of gibberellins and forced open dark closed stomata. The deionized amphoteric peptides solution after passing through cation and anion exchanger resins was run through Amicon's ultrafilters, 10, 3 and 0.5 kDa (M(r)) cut off system. The 3 to 0.5 kDa ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::In the present study, antibacterial activity of aqueous and organic extracts of Psidium guajava leaves was evaluated against multidrug resistant (MDR) clinical isolates of Staphylococcus aureus strains collected from hospitals in northern (Malabar region) Kerala. The strains which exhibited resistance against all the ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::The effect of the oral administration of megestrol acetate (MA; 17 alpha-acetoxy-6-dehydro-6-methylprogesterone) for 30 days at a dose of 40 mg/kg body weight/day on the genital organs and fertility of male rats was studied. MA had no effect on spermatogenesis or the fertility of the animals. However, the weights of...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1965-10-01 00:00:00
abstract::The antitumor effect of allosensitization with lymphocytes and skin graft of DBA/2 mice was evaluated using immunogeneic, transplantable Lymphosarcoma (LS-A) syngeneic to Swiss mice. A dose dependent tumor inhibitory effect in terms of tumor free mice was observed in mice sensitized i.p. with lymphocyte doses between ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract::Effects of adrenalectomy and administration of gonadotropins on cell counts of different cell types of spermatogenesis and morphology of the Leydig cells were studied in 30 day old mice. Adrenalectomy (duration, 12 days; age at autopsy 42 days) caused a significant decrease in the diameters of seminiferous tubules and...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract::The Internet is a massive expanding body of information, which is likely to play a significant role for clinicians and researchers across the world. Since its inception in December 1969 the Internet has grown rapidly and is anticipated to expand 1,000% in the coming next few years. Various useful databases on human ge...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
doi:
更新日期:2001-06-01 00:00:00
abstract::Calcium calmodulin dependent protein ser/thr phosphatase, also referred to as protein phosphatase 2B (PP2B), is rich in neural tissue, and plays an important role in the overall function of the nervous system. Routinely phosphatase assay employs, para-Nitrophenlylphosphate (p-NPP), as a substrate, is also extended to ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00