Abstract：
:Cigarette smoking has been established as a major risk factor for atherosclerosis and also for lung cancer. Nicotine is one of the major components of cigarette smoke which is believed to be partly responsible for the deleterious effect of cigarette smoke. There was significant alteration in the concentration of glycosaminoglycans (GAG) in rats exposed to cigarette smoke. Administration of nicotine to rats has been found to decrease many of GAG fractions in the aorta, liver and heart and increase in the lungs. The increase in GAG now observed in lung tissue in rats administered nicotine and those exposed to cigarette smoke may be involved in the increased incidence of lung cancer in smokers. Increased activity of many of GAG hydrolysing enzymes indicates increased degradation of GAG. Sulphate metabolism in the liver is also significantly altered by nicotine. Thus administration of nicotine to rats caused alteration in the metabolism of GAG which are similar to those observed on exposure of rats to cigarette smoke, indicating that nicotine content of the tobacco smoke may partly be responsible for the effect on GAG observed on exposure to cigarette smoke.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Latha MS,Vijayammal PL,Kurup PAkeywords:
subject
Has Abstractpub_date
1992-03-01 00:00:00pages
219-23issue
3eissn
0019-5189issn
0975-1009journal_volume
30pub_type
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journal_title：Indian journal of experimental biology
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更新日期：2001-11-01 00:00:00
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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更新日期：1989-12-01 00:00:00
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journal_title：Indian journal of experimental biology
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更新日期：1998-04-01 00:00:00
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journal_title：Indian journal of experimental biology
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doi：
更新日期：1997-12-01 00:00:00
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journal_title：Indian journal of experimental biology
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doi：
更新日期：1989-09-01 00:00:00
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journal_title：Indian journal of experimental biology
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更新日期：1996-08-01 00:00:00
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journal_title：Indian journal of experimental biology
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doi：
更新日期：2004-09-01 00:00:00
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journal_title：Indian journal of experimental biology
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doi：
更新日期：1977-10-01 00:00:00
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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doi：
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更新日期：1990-08-01 00:00:00
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journal_title：Indian journal of experimental biology
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更新日期：2002-05-01 00:00:00
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journal_title：Indian journal of experimental biology
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更新日期：1999-06-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
