Inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate: effect of pre-administration of alpha-tocopherol.

Abstract:

:Rats pre-administered with alpha-tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of alpha-tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and alpha-tocopherol act in a complementary fashion to block free radical formation.

journal_name

Indian J Exp Biol

authors

Prabhu HR,Nandini M

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

465-8

issue

5

eissn

0019-5189

issn

0975-1009

journal_volume

45

pub_type

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