Abstract：
:Achyranthes apsera is an abundant indigenous herb in India. Extracts of the whole plant had shown an abortifacient effect in mice. Maximal activity was in the benzene extract which was tested. The drug, in olive oil, was given orally to rabbits in doses of 50 mg/kg of body weight on the 8th day postcoitum. Laparotomy was done on the 11th day. No implantation sites were found. However, ovaries contained prominent corpus luteum, indicating that the drug had prevented pregnancy. In rats, the drug was given orally as a single dose of 50 mg/kg of body weight on the 6th or 7th day after mating. No effect was observed. In mice the drug was given at a single dose of either 10, 15, 25, or 50 mg/kg of body weight. For toxicity tests in mice, a single dose of 1000 mg/kg of body weight was given. After 1 month animals were autopsied and the organs examined. The drug was nontoxic. For a chronic toxicity test 75 mg/kg of body weight was given every 21 days. After 6 months of drug treatment, blood and tissue samples were examined. No toxic effects were observed. For a teratogenic study, 15 mated female mice were fed 10 or 25 mg/kg of body weight on Day 6 of gestation. 3 generations of offspring showed no malformations. In mice, abortifacient effects were noted with a maximum activity at 50 mg/kg of body weight. The drug showed no estrogenic, antiestrogenic, or androgenic effects in mice. Progesterone or pituitary extract given along with the drug did not prevent abortions in mice. The drug was species-specific in that no abortifacient effect was found in rats.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Pakrashi A,Bhattacharya Nsubject
Has Abstractpub_date
1977-10-01 00:00:00pages
856-8issue
10eissn
0019-5189issn
0975-1009journal_volume
15pub_type
杂志文章abstract：:Influence of silymarin on UDP-glucuronic acid (UDPGA) and glucuronidation activity of freshly isolated rat hepatocytes in suspension and in rat liver in vivo was examined. Viability of the hepatocytes (> 85%) was not altered in Hank's balanced salt solution at least for 4 hr at 37 degrees C under oxygen. Silymarin at ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Chickpea genomic library constructed earlier in phage lambda (EMBL-3) was screened for the presence of chitinase clone using tobacco chitinase cDNA as a probe. Positive clones obtained by primary screening of plaques (2 x 10(6)) were ascertained by secondary and tertiary screening. Presence of chitinase insert in the ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:Pulp and paper mill effluents pollute water, air and soil, causing a major threat to the environment. Several methods have been attempted by various researchers throughout the world for the removal of colour from pulp and paper mill effluents. The biological colour removal process uses several classes of microorganism...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2003-11-01 00:00:00
abstract：:Mowrah (M. latifolia) seeds yield 40-50% edible fat and the meal contains saponins besides protein and high level of carbohydrates. The toxicity of the meal was evaluated as it has a potential for use in animal feedstuffs. The meal was fed to young and adult rats at levels of 10 to 40% in diet. The animals showed mark...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:A cobalt-resistant wall-less mutant of N. crassa (Cor-sl) characterized previously was also found to be 3-fold more resistant to nickel when compared to the parent wall-less mutant (W-sl). The Cor-sl strain accumulates relatively lower amounts of nickel when compared to W-sl. Sub-cellular fractionation showed signific...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：:Fishmeal extract bile salt lactose agar (FEBLA), a new differential medium for enteric bacteria was developed and evaluated for its ability to grow and differentiate lactose fermenters (LF) from non-lactose fermenters (NLF) in comparison with MacConkeys agar. Performance of FEBLA was at par with the latter. On FEBLA m...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
abstract：:Potentiality of C. tropicalis and D. polymorphus, to produce surface active compounds (bioemulsifiers/biosurfactants) during shake cultivation on hexadecane and oily waste was studied. Better emulsification activity, specific towards aromatic hydrocarbons, was observed with C. tropicalis culture broth. Emulsification ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:The aim of the present study was to isolate, identify and characterize the secretory proteins of IVM oocytes and IVMFC embryos to evaluate its immunogenecity. and identify of such proteins if any, in blood circulation of estrus and early pregnant goats. Oocytes were matured in TCM-199 with 1 microg/ml, estradiol-17bet...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
abstract：:Haridradi ghrita, a ghee based polyherbal formulation, (50, 100, 200 and 300 mg/kg) significantly lowered marker enzymes (SGPT, SGOT, ALP) and bilirubin in serum and liver peroxide, superoxide dismutase and catalase in liver homogenate following CCl4 (0.7 ml/kg, ip) toxicity. The protective effect was further supporte...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:Presence of angiotensin converting enzyme (ACE, EC 3.4.15.1) in female reproductive tract and its interaction with semen has been investigated in domestic fowl. Higher activity of ACE was detected in homogenates of infundibulum region followed by magnum and relatively low level was noticed in rest of the parts of the ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:An unusual nucleolar organizer region (double NOR) on chromosome 13 was observed in a Down syndrome child [47, XY, +21, dNOR(13)]. The variant chromosome was inherited from the mother [46, XX, dNOR(13)]. The extra chromosome 21 in the proband was maternal origin. The frequency of NOR chromosome association showed rela...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:Maize (Zea mays L. cv kanaujia) plants grown with Zn [10 (control), 0.1 (low) and 20 microM (high)], were investigated for concentration of antioxidants and activities of antioxidative enzymes in leaves. Young leaves of low Zn plants developed whitish-necrotic spots. Leaves of both low and high Zn plants showed decrea...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：:Cognitive disorders in mankind are not uncommon. Apart from neurodegenerative diseases such as Alzheimer's (AD), various stresses also affect cognitive functions. Plants are known to be potential source of compounds that ameliorate several diseases including cognitive impairment. Here, we evaluated effect of aqueous e...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2016-02-01 00:00:00
abstract：:Urine samples, collected from Sprague Dawley rats treated with extracts of tobacco/masheri, benzo (a) pyrene, N'-nitrosonornicotine, N'-nitrosodiethylamine and maintained on semi-synthetic diets sufficient or deficient in Vitamin A, B and protein were tested for mutagenicity using Salmonella/microsome assay. The mutag...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:Thermoactinomycetes vulgaris is a thermophilic actinomycetes growing optimally at 50 degrees C and Streptomyces albus, S. coelicolor, S. fasciculus and S. olivochromogenes are thermophilically disposed transition species of actinomycetes, which have optimum biomass at 40 degrees C. The acid/alkaline phosphatase and ac...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:Incidence of obesity and diabetes is increasing at an alarming rate not only among the populations of the affluent nations but also amongst the populations of the developing nations. Understanding the mechanisms that cause the onset of these pathological conditions is a requisite to effectively tackling this problem. ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2000-09-01 00:00:00
abstract：:Enzymed-linked immunosorbent assay of hilsa and pomfret muscle extracts showed specific IgE binding to ten allergic patients' sera, the results corroborated to that of skin prick test. Comparison of allergen profiles of the two fish extracts by immunoblotting revealed a common antigenic protein of 50 kDa and some high...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-12-01 00:00:00
abstract：:The present study is planned to assess the diagnostic relevance of silver stained nucleolar organizer regions (NORs) in discriminating benign from malignant lesions of the breast and to ascertain the interobserver variability in the enumeration of AgNOR counts. Forty four specimens of benign and malignant breast tissu...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:Daily treatment of CCl4(3 ml/kg body wt) for 7 days induced acute hepatic necrosis in albino rats. Treatment of CCl4 caused significant alterations in the activities of acid lipase, alkaline lipase, lipoprotein lipase of liver, kidney and adipose tissue and hormone sensitive lipase of adipose tissue of albino rat. Adm...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Antinociceptive activity of methanolic extract of leaves of A. aspera was studied by peripheral/non-narcotic model of nociception like acetic acid induced writhing syndrome test and central/narcotic models like hot plate and tail flick tests. The methanolic extract of the plant, administered orally (@ 300, 600 and 900...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-08-01 00:00:00
abstract：:EHb-a herbo-mineral formulations of iron (ferrous form) produced a significantly higher and dose dependent increase in the haemoglobin level, as compared to Fefol (a non-complex-chelated iron preparation). Also, EHb did not produce any overt toxicity or gastric irritation at these dose levels. The results suggest that...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:Reduction of p-benzoquinone to hydroquinol has been studied using Saccharomyces cerevisae and S.uvarum. Maximum conversion of p-Benzoquinone (p-BQ) to Hydroquinol (HQ) at a substrate concentration of 6%. S. cerevisae was found to be better than S. uvarum. No further conversion did take place after 60 hr. Optical innoc...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Effects of a selective monoamine oxidase (MAO)--A inhibitor, clorgyline, a selective MAO-B inhibitor, deprenyl, and a non-selective MAO inhibitor, nialamide, were investigated on footshock-induced aggression (FIA) in paired rats. The doses and pretreatment times of the inhibitors used were based on an earlier reported...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:Anticancer potential of Moringa oleifera L. extracts have been well established. However, there are no reports on the isolated molecules/fractions from these extracts which are responsible for the anticancer/cytotoxic activity. Thus, in the present study, we explored the same. The n-hexane, chloroform, ethyl acetate, ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
abstract：:Considering the lipophilicity of aspirin (log P = -1.15), a significant contributor to its action mechanism, interaction of the drug with the whole lipids of goat blood have been investigated using phospholipid binding and lipid peroxidation phenomena as the parameters under investigation. The lipid content change alo...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Intramuscular injection of 3-[p-(N-2-pyrimidylsulfamoyl)phenylhydrazono]pentane-2,4-dio ne (compound I) resulted in decrease in haemoglobin and alanine transaminase (ALT) and increase in aspartate transaminase (AST) values in albino rats. The serum glucose was found to decrease and after administration of 14 doses of ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:Mechanism of microtuberization in three elite cultivars kufri badhsha (KB), kufri chandramukhi (KCM) and kufri jawahar (KJ) of potato was studied. Sprouts of all the three cultivars were used to obtain in vitro shoot cultures. MS medium supplemented with chlorocholine chloride was found to be most suitable for all the...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：:Rate of heat production during cell proliferation following UV-irradiation of respiratory-deficient yeast cells was measured as a function of time (p-t curve) in a batch microcalorimeter. Following observations were made: (a) All growing cell cultures showed 3 distinct phases of heat production namely lag, exponential...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:Pseudomonas aeruginosa MCCB 123 was grown in a synthetic medium for beta-1,3 glucanase production. From the culture filtrate, beta-1,3 glucanase was purified with a molecular mass of 45 kDa. The enzyme was a metallozyme as its beta-1,3 glucanase activity got inhibited by the metal chelator EDTA. Optimum pH and tempera...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Cheek gland secretions from sexually mature and reproductively active male and female laboratory rats (Wister strain), Rattus norvegicus albinus were analysed by gas chromatography/mass spectroscopy. Alkanes, aliphatic acids esters and alcohols were identified in the secretions. Cheek gland preparation from males cont...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
