Abstract:
:Considering the lipophilicity of aspirin (log P = -1.15), a significant contributor to its action mechanism, interaction of the drug with the whole lipids of goat blood have been investigated using phospholipid binding and lipid peroxidation phenomena as the parameters under investigation. The lipid content change along with the peroxidation induced by aspirin and its suppression with ascorbic acid had been quantitatively measured. Significant loss in phospholipid was observed after incubation of whole blood with aspirin in varying periods of time. This may be ascribed to binding affinity of aspirin with lipid constituents in blood, which may have potential role in its therapeutic effect. Lipid peroxidation induction potential of aspirin caused significant extent of peroxidation. Ascorbic acid, an antioxidant could significantly reduce aspirin induced lipid peroxidation.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Saha A,De AU,Sengupta Ckeywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
912-5issue
9eissn
0019-5189issn
0975-1009journal_volume
38pub_type
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