Abstract：
:Role of 5-HT3 receptors in cholinergic hypofunctional models of cognitive impairment in the elevated plus maze model and a passive avoidance model is studied. Cognitive impairment was caused by scopolamine (1 mg/kg, ip) in mice and 5-HT3 ligands mCPBG (1 and 5 mg/kg, ip) and ondansetron (0.5 and 5 mg/kg, ip) were administered before the pre-learning phase to study the effects on acquisition, while post-learning administration was used to determine the effects on consolidation. Ondansetron improved acquisition and retention in cholinergic hypofunctional models while mCPBG potentiated selected impaired cognitive indices. The results indicate the role of 5-HT3 receptors in cognition and that an ideal evaluation of 5-HT3 ligands in cognition should distinguish true cognitive effects from locomotor, motivational and emotional effects.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Sridhar N,Veeranjaneyulu A,Arulmozhi DK,Gupta CN,Babu RJkeywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
174-80issue
2eissn
0019-5189issn
0975-1009journal_volume
40pub_type
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