Sub-chronic arsenic exposure aggravates nephrotoxicity in experimental diabetic rats.

Abstract:

:The present experiment was planned to study nephrotoxicity in experimental diabetic rats under sub-chronic exposure to arsenic. Alloxan induced diabetic and control rats were exposed to sodium arsenite (0 and 5.5 mg/kg, orally) for 30 days. More pronounced nephrotoxic effects were noted in arsenic exposed diabetic group as evidenced by increased blood urea nitrogen, serum creatinine and relative kidney weight and decreased level of reduced glutathione and glutathione peroxidase activity compared to non arsenic exposed diabetic group. Increased level of lipid peroxidation, protein oxidation, superoxide dismutase and catalase activities under diabetic condition remained unchanged in arsenic exposed diabetic group compared to unexposed diabetic group.

journal_name

Indian J Exp Biol

authors

Patel HV,Kalia K

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

762-8

issue

7

eissn

0019-5189

issn

0975-1009

journal_volume

48

pub_type

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