Abstract:
:The present experiment was planned to study nephrotoxicity in experimental diabetic rats under sub-chronic exposure to arsenic. Alloxan induced diabetic and control rats were exposed to sodium arsenite (0 and 5.5 mg/kg, orally) for 30 days. More pronounced nephrotoxic effects were noted in arsenic exposed diabetic group as evidenced by increased blood urea nitrogen, serum creatinine and relative kidney weight and decreased level of reduced glutathione and glutathione peroxidase activity compared to non arsenic exposed diabetic group. Increased level of lipid peroxidation, protein oxidation, superoxide dismutase and catalase activities under diabetic condition remained unchanged in arsenic exposed diabetic group compared to unexposed diabetic group.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Patel HV,Kalia Ksubject
Has Abstractpub_date
2010-07-01 00:00:00pages
762-8issue
7eissn
0019-5189issn
0975-1009journal_volume
48pub_type
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