Abstract:
:Cyclophosphamide is a potent immunosuppressive agent and is being widely used in organ transplantation. The effects of this anti-rejection drug on lymphoid organs are poorly understood. Newborn Swiss mice injected with various doses of cyclophosphamide suffered from wasting disease at 4 weeks post treatment. The incidence of wasting disease was dose dependent. Haematological picture of the wasting animals revealed leukocytosis of variable degree. Lymphocyte/granulocyte ratio was not inhibited. The cyclophosphamide treatment caused shrinkage of lymphoid organs. Bone marrow showed degeneration of haematopoietic cells. The failure to sustain lymphopoiesis by the potential lymphoid sites following cyclophosphamide treatment and the associated immunological insufficiency resulted in the fatal wasting disease.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Bains GS,Dhake GSkeywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
1-4issue
1eissn
0019-5189issn
0975-1009journal_volume
30pub_type
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Indian journal of experimental biology
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doi:
更新日期:1992-11-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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更新日期:2002-05-01 00:00:00
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
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doi:
更新日期:1998-01-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
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doi:
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