Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.

Abstract:

:Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.

journal_name

Indian J Exp Biol

authors

Kumar G,Banu GS,Kannan V,Pandian MR

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

351-5

issue

4

eissn

0019-5189

issn

0975-1009

journal_volume

43

pub_type

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