Abstract：
:Aqueous extract of T. cordifolia inhibited Fenton (FeSO4) reaction and radiation mediated 2-deoxyribose degradation in a dose dependent fashion with an IC50 value of 700 microg/ml for both Fenton and radiation mediated 2-DR degradation. Similarly, it showed a moderate but dose dependent inhibition of chemically generated superoxide anion at 500 microg/ml concentration and above with an IC50 value of 2000 microg/ml. Aqueous extract inhibited the formation of Fe2+-bipiridyl complex and formation of comet tail by chelating Fe2+ ions in a dose dependent manner with an IC50 value of 150 microg/ml for Fe2+-bipirydyl formation and maximally 200 microg/ml for comet tail formation, respectively. The extract inhibited ferrous sulphate mediated lipid peroxidation in a dose-dependent manner with an IC50 value of 1300 microg/ml and maximally (70%) at 2000 microg/ml. The results reveal that the direct and indirect antioxidant actions of T. cordifolia probably act in corroboration to manifest the overall radioprotective effects.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Goel HC,Prem Kumar I,Rana SVkeywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
727-34issue
6eissn
0019-5189issn
0975-1009journal_volume
40pub_type
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journal_title：Indian journal of experimental biology
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doi：
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journal_title：Indian journal of experimental biology
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