Abstract：
:Recognition of Nitric oxide (NO) as the chemical entity of endothelium-derived relaxing factor (EDRF) has renewed the interest of the scientific community in the last decade. The outcome of research the world over is that the dreaded environmental pollutant is found to be a fundamental physiological mediator and effector. NO is synthesized endogenously by enzymes nitric oxide synthase (NOS) in specialized tissues from its precursor L-arginine. The L-arginine-NO biosynthetic pathway is involved in physiological processes such as vasodilation, memory, neuroprotection, peristalsis, penile erection, immune defense, various endocrine and exocrine secretions in various systems such as cardiovascular, CNS, reproductive and immune system. Small quantities of NO produced by constitutive enzymes mediate these physiological effects. The expression of inducible enzyme or overstimulation of constitutive enzymes leading to production of large quantities of NO is implicated in the cytotoxic effects observed in various disorders like AIDS, cancer, Alzheimer's, arthritis etc. In conclusion, NO is a 'double edged sword' and the challenge before the scientific community is to develop strategies for using it to our advantage.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Shinde UA,Mehta AA,Goyal RKkeywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
201-10issue
3eissn
0019-5189issn
0975-1009journal_volume
38pub_type
杂志文章,评审abstract：:The role of acetylation in the antiglycating and anticataract effects of aspirin (ASA) is explored by comparing ASA's effects with that of sodium salicylate (SS), a nonacetyl analog of ASA, on cataract development in diabetic rats. Streptozocin diabetic rats were provided with either ASA or SS, orally, for 24 weeks. A...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
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更新日期：1998-07-01 00:00:00
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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更新日期：1999-09-01 00:00:00
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journal_title：Indian journal of experimental biology
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更新日期：1999-09-01 00:00:00
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
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journal_title：Indian journal of experimental biology
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doi：
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journal_title：Indian journal of experimental biology
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doi：
更新日期：2006-03-01 00:00:00
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journal_title：Indian journal of experimental biology
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doi：
更新日期：1992-02-01 00:00:00
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journal_title：Indian journal of experimental biology
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更新日期：1999-06-01 00:00:00
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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doi：
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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更新日期：2001-12-01 00:00:00
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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更新日期：1999-08-01 00:00:00
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pub_type： 杂志文章
doi：
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