Abstract：
:The present study was designed to evaluate the learning and memory, in an altered physiological state associated with increased blood pressure and activated renin angiotensin system in Wistar rats. The role of angiotensin in cognitive function was assessed by treatment with angiotensin converting enzyme (ACE) inhibitor enalapril (2 mg/kg), angiotensin 1 receptor (AT(1)) antagonist losartan (5 mg/kg) and their combination. The experimental renal hypertension was induced by the method of Goldblatt. Learning and memory was assessed using the radial arm maze test. Acetylcholine esterase (AChE) levels in the pons medulla, hippocampus, striatum and frontal cortex were measured as a cholinergic marker of learning and memory. Results indicate that in comparison to normotensive rats, renal hypertensive rats committed significantly higher number of errors and took more trials and days to learn the radial arm maze learning and exhibited memory deficit in the radial arm maze retrieval after two weeks of retention interval, indicating impaired acquisition and memory. Treatment with enalapril, losartan and their combination attenuated the observed memory deficits indicating a possible role of renin angiotensin system in cognitive function. AChE level was reduced in hippocampus and frontal cortex of renal hypertensive rats which could be attributed to the observed memory deficit in hypertensive rats. It can be concluded that, renal hypertensive rats had a poor acquisition, retrieval of the learned behavior, perhaps a possible disturbance in memory consolidation process and that this state was reversed with ACE inhibitor enalapril and AT 1 receptor antagonist losartan.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Srinivasan J,Jayadev S,Kumaran D,Ahamed KF,Suresh B,Ramanathan Mkeywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
241-6issue
3eissn
0019-5189issn
0975-1009journal_volume
43pub_type
杂志文章abstract：:A new cell line has been established from larval hemocytes of the moth, S. litura (tobacco cut worm). It took 147 days to form a monolayer and one year for the first 17 passages. At present, the culture is at 86th passage level and is designated NIV-SU-1095. Three cell types could be distinguished, viz. plasmatocytes ...
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journal_title：Indian journal of experimental biology
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更新日期：2006-04-01 00:00:00
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journal_title：Indian journal of experimental biology
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更新日期：1990-04-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1977-08-01 00:00:00
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journal_title：Indian journal of experimental biology
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更新日期：1993-03-01 00:00:00
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pub_type： 杂志文章
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
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journal_title：Indian journal of experimental biology
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doi：
更新日期：1993-12-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
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更新日期：1996-09-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
