Abstract:
:Satavari mandur (SM) is a herbo-mineral preparation containing Asparagus racemosus, which finds mention in ancient Indian texts for treatment of gastric ulcers. The ulcer protective effect of SM, 125-500 mg/kg given orally, twice daily for three, five and seven days, was studied on cold restraint stress-induced gastric ulcer in rats. The effective regimen was found to be 250 mg/kg given for five days and hence was used for further experiments. SM showed significant protection against acute gastric ulcers induced by pyloric ligation but was ineffective against aspirin- and ethanol-induced ulcers. Further, gastric juice studies showed that, SM significantly increased the mucosal defensive factors like mucus secretion, but had little or no effect on offensive factors like acid and pepsin secretion.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Datta GK,Sairam K,Priyambada S,Debnath PK,Goel RKkeywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
1173-7issue
10eissn
0019-5189issn
0975-1009journal_volume
40pub_type
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