Abstract:
:Safety and immunogenicity of Brucella abortus RB51 vaccine has been evaluated in an organised dairy farm in India. All the cattle (r = 29) vaccinated with strain RB51 'responded' to the vaccine as demonstrated by iELISA using acetone killed strain RB51 antigen. The percentage responders at day 35, 60 and 90 post vaccination were 100%, 95% and 20%, respectively. Strain RB51 was able to elicit a good IFN-gamma response from vaccinated animals. The post-vaccination time point analysis indicated that the cumulative IFN-gamma response of whole blood from vaccinates stimulated with heat killed RB51 antigen was elicited in 80% of calves at 60 days post vaccination. Absence of strain RB51 in the secretions and excretion and lack of local or systemic reaction indicated the safety of the vaccine.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Singh R,Basera SS,Tewari K,Yadav S,Joshi S,Singh B,Mukherjee Fsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
239-42issue
3eissn
0019-5189issn
0975-1009journal_volume
50pub_type
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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doi:
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journal_title:Indian journal of experimental biology
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doi:
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doi:
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doi:
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doi:
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doi:
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pub_type: 杂志文章
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