In vitro percutaneous absorption of verapamil.

Abstract:

:The in vitro percutaneous absorption of verapamil hydrochloride (VHCl) was investigated in order to assess its feasibility for transdermal development. The experiments were carried across mice and guinea pig skins using Keshary-Chien diffusion cell. The values of diffusion rate (J) and permeability coefficient (Kp) across guinea pig skin were lowered as compared to mouse skin. Increased drug concentration in donor compartment increased value of J but decreased value of Kp. Under similar conditions, values of J and Kp were lowered for dorsal skin as compared to abdominal skin, both for mice and guinea pig. The results indicate that verapamil can be administered transdermally.

journal_name

Indian J Exp Biol

authors

Jain GK,Agrawal SS

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

475-7

issue

5

eissn

0019-5189

issn

0975-1009

journal_volume

34

pub_type

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