Abstract:
:The in vitro percutaneous absorption of verapamil hydrochloride (VHCl) was investigated in order to assess its feasibility for transdermal development. The experiments were carried across mice and guinea pig skins using Keshary-Chien diffusion cell. The values of diffusion rate (J) and permeability coefficient (Kp) across guinea pig skin were lowered as compared to mouse skin. Increased drug concentration in donor compartment increased value of J but decreased value of Kp. Under similar conditions, values of J and Kp were lowered for dorsal skin as compared to abdominal skin, both for mice and guinea pig. The results indicate that verapamil can be administered transdermally.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Jain GK,Agrawal SSsubject
Has Abstractpub_date
1996-05-01 00:00:00pages
475-7issue
5eissn
0019-5189issn
0975-1009journal_volume
34pub_type
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
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journal_title:Indian journal of experimental biology
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更新日期:1996-04-01 00:00:00
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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journal_title:Indian journal of experimental biology
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更新日期:1993-01-01 00:00:00
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doi:
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
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更新日期:2001-10-01 00:00:00
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doi:
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journal_title:Indian journal of experimental biology
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::Radiosensitizing effects of combination of a minor groove DNA ligand, Hoechst-33342, with the glucose analogue and inhibitor of glycolysis, 2-deoxy-D-glucose (2-DG) have been investigated in Ehrlich ascites tumour (EAT) bearing mice following focal irradiation of the tumour with 60Co gamma-rays. Treatment-induced tumo...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
doi:
更新日期:2004-11-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
doi:
更新日期:2001-05-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Administration of tarakeswara rasa--an ayurvedic drug--to alloxan induced diabetic rats resulted in a significant decrease in the blood glucose. Its antidiabetic effect was also evident from the tissue parameters estimated. The drug administration to diabetic rats also resulted in the reduction of cholesterol, triglyc...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00