Abstract:
:N-formyl-methionyl-leucyl-phenylalanine (fMLP) a potent chemotactic peptide stimulates immune responses by activating macrophages and other cells of the immune system. The present study reports inhibition of fMLP-induced activation of murine peritoneal and P388D-1 macrophage cell line by protein kinase C (PKC) inhibitors, H-7 and chelerythrine chloride. Similarly, tumoricidal activity was also downregulated by protein tyrosine kinase (PTK) inhibitors genestein and lavendustin A. Further, fMLP increased tyrosine phosphorylation of several proteins in murine macrophages, which were inhibited in presence of genestein and lavendustin A. These findings suggest the involvement of PKC and PTK in the activation of murine macrophages with fMLP.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Shrivastava Asubject
Has Abstractpub_date
2007-09-01 00:00:00pages
755-63issue
9eissn
0019-5189issn
0975-1009journal_volume
45pub_type
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