Abstract：
:Ponderal, histological, and biochemical responses of the uterus, cervix, and vagina to the same dosage (1.5 mg/kg/day for 5 days) of cis- and transclomiphene were studied in ovariectomized rats in the presence and absence of estradiol-dipropionate (EDP). The results indicated that both isomers were estrogenic-cum-antiestrogenic. However, the estrogenicity of the 2 compounds relative to each other and to EDP and their antiestrogenic potentials varied depending on the parameter and the nature of the target organ under consideration. Both isomers increased the weight of the uterus, cervix, and vagina. Histologically both stimulated the organs broadly but not in details like EDP. Biochemically, transclomiphene raised the 2 estrogen-dependent parameters (lactic acid and alkaline phosphatase) of the cervix more effeciently. Statistical analyses are presented. It is suggested that ehse anomalies might arise from the nugnces in the ponderal, histological, and biochemical behavior of the 3 target organs and the variation in the threshold doses of the compounds necessary to elicit a certain biochemical response from a particular organ. The inherent ability of a compound to evoke a change over and above that which could be imputed to its estrogenicity/antiestrogenicity might also complicate the issue.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Karkun JN,Mehrotra PKsubject
Has Abstractpub_date
1973-01-01 00:00:00pages
7-14issue
1eissn
0019-5189issn
0975-1009journal_volume
11pub_type
杂志文章abstract：:Prevalent notion about thyroid hormones is that thyroxine (T4) is a mere precursor and physiological effects of thyroid hormones are elicited by tri-iodothyronine (T3) after mono-deiodination of T4. Earlier studies on feather regeneration and molt done on spotted munia L. punctulata suggest that T4 (mono-deiodination ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：:The alkaloids from the ethanolic extract of H. antidysenterica seeds were evaluated for their antibacterial activity against clinical isolates of enteropathogenic Escherichia coli (EPEC) in vitro, and their antidiarrhoeal activity on castor oil-induced diarrhoea in rats, in vivo. The plasmid DNA, whole cell lysate and...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:Mechanisms of interleukin-18 (IL-18) and interleukin-10 (IL-10) in lipopolysaccharide (LPS) induced endotoxemia are not clear; their protective role is being investigated so that they may effectively modulate the host cytokine levels during endotoxemia. The aim of the study was to evaluate protective effects of IL-18 ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：:Staphylococcus sp. strain BP/SU1, capable of degrading the biopolymer and utilize it as a source of carbon and energy, was isolated from activated sludge using METABOLIX (MBX D411G). It was found that this strain was capable of accumulating poly(3-hydroxybutyric acid) P(3-HB), as granule poly (3-hydroxybutyric acid), ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2009-04-01 00:00:00
abstract：:Chickpea genomic library constructed earlier in phage lambda (EMBL-3) was screened for the presence of chitinase clone using tobacco chitinase cDNA as a probe. Positive clones obtained by primary screening of plaques (2 x 10(6)) were ascertained by secondary and tertiary screening. Presence of chitinase insert in the ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:In dengue type 2 virus (DV)-induced suppressor T cell cascade TS1 cells secrete a suppressor cytokine (SF) which acts via syngeneic macrophages (M phi) to recruit TS2 cells. SF binds to both high and low affinity receptors (SF-R) on M phi. In the present study the fate of SF in M phi during transmission of suppressor ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
abstract：:Goat epididymal and ejaculated spermatozoa were incubated in Krebs-Ringer bicarbonate buffer containing pyruvate and lactate as energy source. A 3 hr incubation for epididymal and 4 hr for ejaculated spermatozoa was required for the capacitation and acrosome reaction to take place. Calcium is an essential requirement ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：:Molecular oxygen, a diradical, needs intervention of redox metal ions or other radicals to receive electrons for its reduction. The oxygen radicals thus produced are responsible for oxygen toxicity and oxidative stress. But, autoxidation, relevant in ischemia-reperfusion injury, is absent in any discussion on oxygen t...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2016-11-01 00:00:00
abstract：:Natural Killer activity assessed by 51Cr release assay from K-562 cells showed detectable activity from 5th day after tumour transplantation, reaching a peak on 12th day and thereafter showing a gradual decline in the activity. Antibody dependent cell mediated cytotoxicity estimated by 51Cr labelled sheep red blood ce...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:Since aging is the most important risk factor for variety of diseases, the discovery of a wide range of chemical modulators of aging in model organisms encourages new strategies for targeting age associated diseases. Simple genetic manipulation leads to long-lived and healthy animals, so any compound which could have ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：:Lipopolysaccharide (LPS) and ratio-detoxified LPS (Rd-LPS) from Salmonella typhimurium were analysed for their ability to stimulate murine peritoneal exudate cells (PEC) and macrophages. Rd-LPS induced much more inflammatory response as compared to LPS. PEC numbers/mouse obtained were significantly higher (3-fold) in ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Mouse B16LuF1 melanoma cells of lower metastatic potential to lung were treated in vitro with same concentration (50 microM) of gangliosides prepared from plasma of mice bearing lung metastasis of B16LuF5, B16LuF9 or B16LuF10 melanoma cell lines of increasing metastatic potential to lung (LuF1 < LuF5 < LuF9 < LuF10) a...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：:According to Ayurvedic literature of Sri Lanka, roasted seeds of Artocarpus heterophyllus Lam. (Family: Moraceae) has aphrodisiac activity. However, some reproductively active young men in rural areas of Sri Lanka claim that consumption of these seeds few hours prior to coitus disrupts sexual function. Because of thes...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Haloperidol, a butyrophenone used in the treatment of various psychoses has been clinically used and studied extensively. At the molecular level it is known to preferentially block D2 type of dopamine receptors but its other effects are unknown. We studied the effect of this drug on phospholipid biosynthesis in vitro ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Efforts have been made to minimize the toxic effect caused by beryllium. Adult cyclic rats of Sprague Dawley strain were administered a bolus dose of 50mg/kg beryllium nitrate intramuscularly. The chelation therapy with glutathione (GSH), dimercapto propane sulfonic acid (DMPS)+ selenium (Se) and D-Penicillamine (DPA)...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-08-01 00:00:00
abstract：:The mechanism of Agrobacterium mediated genetic transformation of plants is dependent upon certain genetic function of the chromosome of the bacterium as well as on Ti-plasmid borne vir loci and the border sequences of T-DNA. The organisationally variable forms of the naturally occurring border sequences amongst Ti-pl...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:Antioxidant role of Arogh in isoproterenol induced myocardial infarction in rats has been studied. The activity of heart tissue antioxidants like glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase were significantly decreased in isoproterenol administered group. The activ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
abstract：:A study was conducted of the effect of intravaginal instillation of 3 nonsteroidal oran antifertility agents in pregnant rats. The 3 compounds used were 2-phenyl-3-rho-beta-pyrrolidinoethoxyphenyl-6-methox y benzofuran hydrochoride (DBF), 20 mg/kg; 2-phenyl-3-rho-beta-pyrrolidi noethoxyphenyl-naptha (2:1,b furan (NF...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1974-07-01 00:00:00
abstract：:Breast cancer is a common malignancy in women all over the world and novel therapeutic approaches are required for the treatment of patients who become refractory to conventional therapies. Thyroid cancer is being treated successfully with radioiodine since many years. The iodide is transported inside the thyroid epit...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:Repeated weekly infections with S aureus, of bovine mammary origin, for three times evoked an immediate and a delayed type hypersensitivity in rabbits. The skin responses at 6 hr were characterized by oedema, haemorrhages and infiltration of polymorphonuclear cells. While at 24 hr it was dominated by mononuclear cells...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Bioremediation is the most promising and cost effective technology widely used nowadays to clean up both soils and wastewaters containing organic or inorganic contaminants. Discharge of chromium containing wastes has led to destruction of many agricultural lands and water bodies. Utilisation of chromium(Cr) reducing m...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2003-09-01 00:00:00
abstract：:Osteosarcoma (OSA) is the most common adolescence cancer among all primary bone tumors next only to multiplemyeloma. It has a substantially worse prognosis and ability to metastasize to lung. MMPs (matrix metalloproteinases) are among the major proteases that take part in regulation of ECM (extracellular matrix). MMPs...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：:Effects of exogenous androgens (testosterone, testosterone propionate and dihydrotestosterone) and estradiol-17beta on the oviductal growth/hypertrophy were studied in young and bilaterally ovariectomized (BLO) adult frogs (Rana cyanophlyctis) during postbreeding phase of the reproductive cycle. Estradiol-17beta injec...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:Formulations (ointment, cream and gel) of aqueous extract of C. asiatica, when applied topically, thrice daily for 24 days on the open wounds in rats increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increase in collagen content and tensile strength. The treated wounds epitheli...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Shoots of apple rootstocks raised in vitro were transferred to various rooting media to study the effect of different factors on root initiation and development. Various concentrations of indole-3-butyric acid (IBA) initiated rooting but maximum rooting percentage was found with 2.0 and 2.5 mg l(-1) of IBA in M7 and w...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:Considering the lipophilicity of aspirin (log P = -1.15), a significant contributor to its action mechanism, interaction of the drug with the whole lipids of goat blood have been investigated using phospholipid binding and lipid peroxidation phenomena as the parameters under investigation. The lipid content change alo...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Aqueous extract of T. cordifolia inhibited Fenton (FeSO4) reaction and radiation mediated 2-deoxyribose degradation in a dose dependent fashion with an IC50 value of 700 microg/ml for both Fenton and radiation mediated 2-DR degradation. Similarly, it showed a moderate but dose dependent inhibition of chemically genera...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:Limb remote ischemic postconditioning (LRIP) can reduce ischemia-reperfusion injury (IRI), but its mechanisms are still unclear. We hypothesize that LRIP reduces IRI by reversing eNOS uncoupling. Focal ischemia was induced in Sprague-Dawley rats by middle cerebral artery occlusion for 2 h followed by a 24 h reperfusio...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：:Octapeptide (OP)/FSH-Receptor Binding Inhibitor-8 (FRBI-8), is a synthetic peptide corresponding to N-terminal sequence of purified fraction of Follicle Stimulating Hormone Binding-Inhibitor (FSHBI), isolated earlier from human ovarian follicular-fluid. In order to avoid the repeated drug-administration, OP-loaded, po...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2013-12-01 00:00:00
abstract：:The Malnad region located in the Western Ghats of Karnataka is known for the cultivation of indigenous rain fed land race cultivar of rice. The present study was to investigate the callogenic and caulogenic potentialities of the two indigenous rice cultivar namely Karimundaga and Kanadatumba using dehusked mature embr...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
