Identification and characterization of receptor for dengue virus-induced macrophage cytotoxin.

Abstract:

:The present study was undertaken to identify the receptor for dengue virus type 2 (DV) induced macrophage cytotoxin (CF2) on mouse peritoneal macrophages (MPhi). The binding of 125I-labelled CF2 to MPhi was saturable (15 nM), reversible, temperature, pH- and time-dependent. The saturation concentration was similar to that causing cell death. Scatchard analysis showed the presence of intermediate type of affinity receptor and the number of receptor sites was 1.1 x 10(6) per cell with dissociation constant of 14.28 nM.

journal_name

Indian J Exp Biol

authors

Khare PD,Dhawan R,Chaturvedi UC

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

652-7

issue

7

eissn

0019-5189

issn

0975-1009

journal_volume

34

pub_type

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