Abstract:
:Nicotine administration (2.5 mg/kg of body weight, sc, 5 days a week for 22 weeks) enhanced lipid peroxidative indices (thiobarbituric acid reactive substances and hydroperoxides) accompanied by a significant increase in the marker enzymes alanine transaminase, aspartate transaminase, alkaline phosphatase and lactate dehydrogenase and elevated levels of cholesterol, triglycerides, phospholipids and free fatty acids in Wistar rats. There was a significant protection by hesperidin administration at different doses (25, 50, 75, 100 and 150 mg/kg body weight) in nicotine-treated rats. However, the effect of hesperidin was more significant at 25mg/kg dose. The results suggest that hesperidin exerts the protective effects by modulating the extent of lipid peroxidation. The results are supported by histopathological observations of lung, liver and kidney.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Balakrishnan A,Menon VPsubject
Has Abstractpub_date
2007-02-01 00:00:00pages
194-202issue
2eissn
0019-5189issn
0975-1009journal_volume
45pub_type
杂志文章abstract::Three lipophilic amide derivatives of phthaloyl-GABA (P-GABA), namely gamma-phthalimido N-amyl butyramide (PGA), gamma-phthalimido-N-hexylbutyramide (PGH) and gamma-phthalimido N-phenylbutyramide (PGP), were synthesized and evaluated for their hypnotic and anticonvulsant activities in mice. Both PGA and PGH showed mod...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::In order to find out the effect of chronic ethanol administration on testicular antioxidant system and steroidogenic enzyme activity, male rats fed with ethanol 1.6g/kg body weight per day for four weeks were studied. Besides a drastic reduction in body and testis weight, there was decrease in ascorbic acid, reduced g...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::In the present study HD-03, a herbal formulation was investigated for its anti-cholestatic activity in TAA-induced cholestasis in anaesthetized guinea pigs. Administration of TAA at a dose of 100 mg/kg body wt significantly reduced the bile flow, bile acid and bile salt excretion. Pretreatment with HD-03 at a dose of ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::Estradiol-17beta (E2) at the dose of 1 microg/g caused an increase in cell area, lumen area and the total (cell + lumen) area of posterior silk gland (PSG) in Bombyx mori indicating that exogenously applied estradiol-17beta has a regulatory influence on silk gland activity. A dose-dependent variation in trehalase acti...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract::Considering the lipophilicity of aspirin (log P = -1.15), a significant contributor to its action mechanism, interaction of the drug with the whole lipids of goat blood have been investigated using phospholipid binding and lipid peroxidation phenomena as the parameters under investigation. The lipid content change alo...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::Regulation of siderophore production in response to iron concentration in the medium was examined. Threshold concentration was recorded for twenty fungi and three rhizobacterial pseudomonads. Organisms showed difference in threshold values at which they stopped siderophore elaboration. In nine fungi (3 aspergilli, 1 p...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::The highly complex nature of the process of ageing implicates both genetic and epigenetic causative factors. A progressive failure of maintenance underlines and typifies this process. The instability of the nuclear and the mitochondrial genomes is an important determinant of ageing. Infidelity and misregulation of gen...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract::Leydig cells are the primary source of androgens in the mammalian testis. It is established that the luteinizing hormone (LH) produced by the anterior pituitary is required to maintain the structure and function of the Leydig cells in the postnatal testis. Until recent years, a role by the thyroid hormones on Leydig c...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
doi:
更新日期:2005-11-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2013-07-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::Acute single dose administration of lanthanum chloride (250 mg/kg body wt, ip) to chicks have been found to alter the levels of enzymes of the antioxidant defence system of chick renal cortex fractions. Such changes involved significant decrease in activities of glucose-6-phosphate dehydrogenase, glutathione reductase...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::The implantation failure in newly inseminated mice induced by food deprivation for 48 hr, beginning at 0900 hrs on day 4 post coitum, was prevented by simultaneous exposure to light continuously for 48 or 36 hr. Food-deprived females that were exposed to continuous light for 36 hr showed a significant increase in feta...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::Aluminium phosphide(AlP), a grain fumigant pesticide, was studied for its cardiotoxicity in anaesthetised rats. The hemodynamic and cardiac biochemical changes were investigated following intragastric administration of different doses of AlP (10, 20 and 40 mg). With 10 and 20 mg dose of AlP an immediate fall in BP was...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::Adrenal delta5-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) activity and serum corticosterone level were significantly higher in rats fed with 5% casein or 4% albumin diets after 1 hr of ether anaesthetic stress as compared to the controls, 5% casein and 20% casein (equivalent to 4% albumin) respectively. Eth...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2003-04-01 00:00:00
abstract::Although peripheral axotomy of dorsal root ganglion cells in mice, rats and cats has been reported to generate spontaneous activity in sensory nerves, we did not find evidence for such activity in the hamster. In vitro, intracellular recording from L6-S1 dorsal root ganglion cells up to 6 weeks after axotomy did not r...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::A strain of T. chilonis, an egg parasitoid of lepidopteran pests tolerant to the most commonly used cyclodiene insecticide--endosulfan was developed in the laboratory. Tolerance to endosulfan was induced by exposing adult parasitoids sequentially from a sub-lethal concentration (0.004%) to the field recommended concen...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::Heart, dorsal aorta and plasma significantly accumulated the lipid components such as triacylglycerol, cholesterol and glycerol in two months period of hysterectomy which may lead to the development of cardiovascular disorders. Administration of PGF2 alpha decreased the lipid fractions of cardiovascular tissues probab...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract::The present study evaluates effect of pharmacokinetic interaction between caffeine (300 mg) in three divided doses with sodium valproate (400 mg) and carbamazepine (200 mg) given as single doses, in normal human volunteers, using a open cross over design. Both the serum concentration of sodium valproate and pharmacoki...
journal_title:Indian journal of experimental biology
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The present study was undertaken to determine the anti-ulcer and antioxidant potential of GutGard, a standardized extract of Glycyrrhiza glabra commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGard was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indo...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1965-10-01 00:00:00
abstract::Aqueous extract of Andrographis paniculata was examined for antioxidant activity using rat liver subcellular organelles as model systems. The study deals with two important biological oxidative agents, ascorbate-Fe(+2) and AAPH generating hydroxyl and peroxyl radical, respectively. Oxidative damage was examined agains...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::Tadpoles of B. melanostictus and R. cyanophlyctis were reared in vitamin A solution. Rearing of the tadpoles of B. melanostictus in solutions containing 15, 20 and 30 IU/ml vitamin A palmitate resulted in complete disappearance of the keratinized epidermal material over the jaws and horny labial teeth. However tadpole...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Formulations (ointment, cream and gel) of aqueous extract of C. asiatica, when applied topically, thrice daily for 24 days on the open wounds in rats increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increase in collagen content and tensile strength. The treated wounds epitheli...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Various storage treatments on human blood samples have been described with respect to DNA yield, quality and fingerprinting. Blood samples were stored at room temperature, 4 degrees C, -20 degrees C and -70 degrees C for different duration varying from 1, 2, 4 and 8 weeks with or without anticoagulant/preservative (ED...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::Drought stress is one of the major factors affecting nitrogen fixation by legume-rhizobium symbiosis. Several mechanisms have been previously reported to be involved in the physiological response of symbiotic nitrogen fixation to drought stress, i.e. carbon shortage and nodule carbon metabolism, oxygen limitation, and...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
doi:
更新日期:2003-10-01 00:00:00
abstract::Electrocardiograms (ECGs) were studied in rats fed vitamin D deficient diet for 12 weeks. The results indicated significant shortening of QT interval of ECG. Other intervals were normal when compared with age matched control rats. Heart/body weight ratio was significantly increased in vitamin D deficient group, which ...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00