Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat.

Abstract:

:Ascorbic acid treatment in arsenic trioxide treated rats increased arsenic excretion, inhibited lipid peroxidation, improved GSH status, regulated GSSG turnover and also restored glutathione-S-transferases activity in liver and kidney. Suitable mechanisms leading to ascorbic acid protection have been discussed. Upregulation of GSH dependent enzymes was found to be necessary for a protective effect. Protection is finally attributed to higher GSH levels observed in the liver and kidney of ascorbic acid and inorganic arsenic treated rats. It is also concluded that ascorbic acid protection is influenced by gender dependent factors. Arsenic poisoning is a global problem now. Gender differences need to be considered while applying therapeutic measures.

journal_name

Indian J Exp Biol

authors

Sohini,Rana SV

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

371-5

issue

4

eissn

0019-5189

issn

0975-1009

journal_volume

45

pub_type

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