Abstract：
:The highly complex nature of the process of ageing implicates both genetic and epigenetic causative factors. A progressive failure of maintenance underlines and typifies this process. The instability of the nuclear and the mitochondrial genomes is an important determinant of ageing. Infidelity and misregulation of genetic information transfer, loss of cellular proliferative capacity, altered cellular responsiveness and defective pathways of signal transduction are major aspects of the failure of homeostasis. These are also the basis of age-related diseases and impairments, such as osteoporosis, arthritis, immune deficiency, altered drug clearance and altered functioning of the brain. Studies directed towards understanding the mechanisms of interaction and inter-dependence of various genes involved in maintenance and repair networks are the most promising research strategies for identifying gerontogenes.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Rattan SIsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
1-6issue
1eissn
0019-5189issn
0975-1009journal_volume
34pub_type
杂志文章,评审abstract：:Head and neck squamous cell carcinoma (HNSCC), a common malignancy that possibly involves a combination of exposure to the carcinogens and inherited genetic differences in the enzymes catalyzing their metabolism. Alcohol and tobacco consumption are the primary environmental risk factors, while polymorphism in various ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2010-07-01 00:00:00
abstract：:Maize (Zea mays L. cv kanaujia) plants grown with Zn [10 (control), 0.1 (low) and 20 microM (high)], were investigated for concentration of antioxidants and activities of antioxidative enzymes in leaves. Young leaves of low Zn plants developed whitish-necrotic spots. Leaves of both low and high Zn plants showed decrea...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：:The aim of the present study was to isolate, identify and characterize the secretory proteins of IVM oocytes and IVMFC embryos to evaluate its immunogenecity. and identify of such proteins if any, in blood circulation of estrus and early pregnant goats. Oocytes were matured in TCM-199 with 1 microg/ml, estradiol-17bet...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
abstract：:Substance P (SP) and neurotensin (NT), two structurally related peptides with contrasting biological actions, have been shown to have some role in peripheral reproductive processes. Intrauterine microinjection of SP or NT on day 4 or 5 of pregnancy in the rat significantly reduced the number of viable fetuses, weight ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:Effect of chronic treatment with hydralazine (40 mg/kg/day) on isolated heart, anococcygeus muscle and myometrial preparations from rats has been studied. The treatment for 6 weeks caused a significant increase in isoprenaline induced positive inotropic response in rat heart. However, isoprenaline induced positive chr...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Urine samples, collected from Sprague Dawley rats treated with extracts of tobacco/masheri, benzo (a) pyrene, N'-nitrosonornicotine, N'-nitrosodiethylamine and maintained on semi-synthetic diets sufficient or deficient in Vitamin A, B and protein were tested for mutagenicity using Salmonella/microsome assay. The mutag...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:Eclosion rhythm parameters of D. ananassae strains originating between 8 degrees-34 degrees N were highly variable and latitude dependent. In the field under naturally fluctuating light intensity, temperature and R.H., the amplitude of the rhythm was high and the eclosion gate was narrow; however, under the naturally ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：:The biodegradation of spent saline bottles, a low density polyethylene product (LDPE) by two selected Arthrobacter sp. under in vitro conditions is reported. Chemical and UV pretreatment play a vital role in enhancing the rate of biodegradation. Treated LDPE film exhibits a higher weight loss and density when compared...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:Pups (5 days old) were undernourished by separating them for 14 hr daily from their mothers for 7, 10, 13, 16 and 20 days. The undernourished rats showed significant decrease in body and brain weight, protein and nucleic acid contents at all stages of observation as compared to controls. The activities of SDH and AChE...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：:Calcium calmodulin dependent protein ser/thr phosphatase, also referred to as protein phosphatase 2B (PP2B), is rich in neural tissue, and plays an important role in the overall function of the nervous system. Routinely phosphatase assay employs, para-Nitrophenlylphosphate (p-NPP), as a substrate, is also extended to ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2014-02-01 00:00:00
abstract：:Mouse melanoma cells were treated with plumbagin, a naphthoquinone, from the plant Plumbago rosea at 0.5 microgram/ml (PI) for 60 min either alone or followed by 2 Gy gamma radiation (RT). Response to the different treatments was assessed by following the cell growth up to 5 days post treatment. PI alone produced a si...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:The monogenean ectoparasite, Dactylogyrus sp. is a major pathogen in freshwater aquaculture. The immune responses in parasitized fish were analyzed by quantitation of innate immune factors (natural agglutinin level, haemolysin titre, antiprotease, lysozyme and myeloperoxidase activities) in serum and immune-relevant g...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：:To evaluate the cardioprotective potential of Inula racemosa in myocardial ischemic-reperfusion injury, Wistar male albino rats were randomly divided into four groups. The group I and II animals were administered saline orally {(sham, ischemia- reperfusion (I-R) control group)} and animals of group III and group IV re...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:Creatinine in serum or urine is determined by Jaffe's reaction where creatinine produces quantitatively an orange color with picric acid in alkaline medium. After allowing an incubation time of 15 min at room temperature for color development the color is measured at 520 nm. Without taking into consideration the acidi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Seven L. acidophilus strains were examined for their antibiotic sensitivity against various chemotherapeutic agents and all of them were found to be sensitive to novobicin, chloramphenicol, ampicillin, erythromycin, oxytetracycline and chlorotetracycline, whereas, all were resistant to norfloxacin and nalidixic acid. ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:The hunt for an effective vaccine against malaria still continues. Several new target antigens as candidates for vaccine design are being explored and tested for their efficacy. In the present study the sera from mice immunized with 24,000 x g fraction of Plasmodium berghei has been used to identify highly immunogenic...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2014-08-01 00:00:00
abstract：:Intramuscular injection of 3-[p-(N-2-pyrimidylsulfamoyl)phenylhydrazono]pentane-2,4-dio ne (compound I) resulted in decrease in haemoglobin and alanine transaminase (ALT) and increase in aspartate transaminase (AST) values in albino rats. The serum glucose was found to decrease and after administration of 14 doses of ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:Present work was undertaken to ascertain the hepatoprotective effect of Swertia chirata in albino rats. Intraperitoneal injection of CCl4 (1 ml/kg body wt on every 72 hr. for 16 days) significantly increased serum aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), and alkaline phosphatase (ALP) activi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:Pulp and paper mill effluents pollute water, air and soil, causing a major threat to the environment. Several methods have been attempted by various researchers throughout the world for the removal of colour from pulp and paper mill effluents. The biological colour removal process uses several classes of microorganism...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2003-11-01 00:00:00
abstract：:Naturally occurring alkaloids are nitrogenous compounds that constitute the pharmacogenically active basic principles of flowering plants. Alkaloids are classified into several biogenically related groups. Tobacco alkaloids are metabolised from polyamines and diamines putrescine and cadaverine. N-methyl transferase is...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2000-11-01 00:00:00
abstract：:The present study was undertaken to identify the receptor for dengue virus type 2 (DV) induced macrophage cytotoxin (CF2) on mouse peritoneal macrophages (MPhi). The binding of 125I-labelled CF2 to MPhi was saturable (15 nM), reversible, temperature, pH- and time-dependent. The saturation concentration was similar to ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:Evaluation of the effects of daily oral administration of ethanolic extract of C. violaceum leaves (13 mg/kg body weight) for 5 days on some kidney function indices of uninfected and Plasmodium berghei-infected mice was done on days 3, 8 and 14 post-infection. The indices studied include serum urea and creatinine conc...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：:Diabetes induced by streptozotocin (50 mg/kg body wt, i.p.) in the rats substantially increased the plasma glucose and malondialdehyde levels along with corresponding decrease in the antioxidants levels. Supplementation of vitamin E (200 mg/kg body wt., ip) for 5 weeks resulted in non-significant decrease in the blood...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-02-01 00:00:00
abstract：:Aqueous extract of T. cordifolia inhibited Fenton (FeSO4) reaction and radiation mediated 2-deoxyribose degradation in a dose dependent fashion with an IC50 value of 700 microg/ml for both Fenton and radiation mediated 2-DR degradation. Similarly, it showed a moderate but dose dependent inhibition of chemically genera...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:Shoots of apple rootstocks raised in vitro were transferred to various rooting media to study the effect of different factors on root initiation and development. Various concentrations of indole-3-butyric acid (IBA) initiated rooting but maximum rooting percentage was found with 2.0 and 2.5 mg l(-1) of IBA in M7 and w...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:Diazepam (10 mg/kg, ip) treatment was given from day 13 to 20 of gestation to pregnant rats, this being the critical period for neural development in this species. The pups born were subjected to open-field exploratory behaviour, tunnel-board exploratory behaviour, elevated zero maze behaviour and social interaction t...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：:Food deprivation produces analgesia. This response is reversed i.e. pain sensitivity is lowered, when the food deprived rats are fed. In the present study the effect of chronic pain on the motivation to get food, in food deprived rats, was observed. In ten rats the effect of formalin and morphine plus formalin on the ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
abstract：:The levels of malondialdehyde and lipofuscin pigments were increased in the prostate of D-galactose (0.5 ml/day, sc, for 20 days) induced aging mice. After B. monniera (40 mg/kg body weight for 20 days) ethanol leaf extract administration levels of both the parameters were reduced significantly. The results suggest th...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：:The Grey Weevil, Myllocerus subfasciatus Guerin, is an important emerging pest of quarantine significance in Solanaceae crops including the eggplant, Solanum melongena. Entomopathogenic nematodes (EPNs) have been shown to be a potential source of safe and effective control of M. subfasciatus. In this study, we determi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2016-12-01 00:00:00
abstract：:Chemical composition of inter and intracellular hyphae was elucidated in Pennisetum pedicellatum roots colonized by Gigaspora margarita by employing energy dispersive X-ray microanalysis. Maximum amount of phosphate was estimated in polyphosphate granules present in the roots. Amount of phosphate was low in fungal hyp...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
