Abstract:
:In order to find out the effect of chronic ethanol administration on testicular antioxidant system and steroidogenic enzyme activity, male rats fed with ethanol 1.6g/kg body weight per day for four weeks were studied. Besides a drastic reduction in body and testis weight, there was decrease in ascorbic acid, reduced glutathione and activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase in the testicular tissue of the treated animals. Simultaneously, there was increase in lipid peroxidation and glutathione S-transferase activity. Activities of 3 beta-hydroxy steroid dehydrogenase and 17 beta-hydroxy steroid dehydrogenase were also found decreased in the treated animals. The results indicate that chronic ethanol administration resulted in increase in oxidative stress and decrease in the activities of steroidogenic enzymes in the rat testes.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Maneesh M,Jayalekshmi H,Dutta S,Chakrabarti A,Vasudevan DMkeywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
445-9issue
5eissn
0019-5189issn
0975-1009journal_volume
43pub_type
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