Abstract：
:The effect of the oral administration of megestrol acetate (MA; 17 alpha-acetoxy-6-dehydro-6-methylprogesterone) for 30 days at a dose of 40 mg/kg body weight/day on the genital organs and fertility of male rats was studied. MA had no effect on spermatogenesis or the fertility of the animals. However, the weights of the genital organs were significantly reduced (p less than .05) and pituitary gonadotropin levels were significantly increased (p less than .01). These alterations were reversed after cessation of treatment. Although MA and testosterone propionate each increase seminal vesicle weight, their combined administration significantly decreased seminal vesicle and ventral prostate weight (p less than .01). The significance of the results are discussed.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Karkun JN,Kar ABsubject
Has Abstractpub_date
1965-10-01 00:00:00pages
213-5issue
4eissn
0019-5189issn
0975-1009journal_volume
3pub_type
杂志文章abstract：:Concentrations of mono- and divalent cations in the testis, three different regions of the epididymis and the vas deferens of lizard, M. carinata were determined. The concentrations of Na+, K+ and Ca2+ increased gradually from testis to vas deferens. However, no significant variation in the levels of Mg2+ was observed...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：:The whole plant aqueous extract of E. littorale was tested for its hypoglycemic activity on normoglycemic, hyperglycemic and alloxan induced diabetic rats. Blood sugar lowering activity was not observed in normoglycemic and glucose loaded hyperglycemic rats in the short time experiment. But in case of diabetic rats, t...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
abstract：:The effects of dopamine (DA) agonists and antagonists were investigated on indomethacin--and restraint stress (6 hr at RT)--induced gastric ulcer formation in rats. The DA-agonists, apomorphine and bromocryptine (both at 5 mg/kg) significantly attenuated the frequency and severity of gastric mucosal lesions in both ex...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Treatment of full-thickness wounds with A. vera, on rats resulted in increased biosynthesis of collagen and its degradation. A corresponding increase in the urinary excretion of hydroxyproline was also observed. Elevated levels of lysyl oxidase also indicated increased crosslinking of newly synthesised collagen. The r...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:An efficient method has been developed for large-scale multiplication of Curculigo orchioides (Hypoxidaceae), an endangered medicinal plant, through direct bulbil formation from leaf explants in shake flask cultures. Leaf-segments (7 x 10 mm) were cultured in B5 liquid medium containing KNO3 (200 mgNL-1), (NH4)2SO4 (5...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-02-01 00:00:00
abstract：:The aim of the present study was to investigate the role of phosphodiesterase (PDE) enzyme inhibitors namely rolipram and theophylline in pain and inflammation in experimental animals. Rolipram, a selective PDE IV inhibitor and theophylline a nonspecific PDE inhibitor exerted dose dependent analgesic and anti-inflamma...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Chronic (2 h/d x 8 weeks) exposure to magnetic field (MF; 50 Hz, 17.9 microT) in complete spinal cord (T13) transected rats restored food intake (FI), water intake (WI) and body weight (BW) which were decreased in the spinal cord injured rats. The results suggest a significant beneficial effect of chronic exposure to ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
abstract：:Nine halophilic archaea viz., Halobacterium salinarum, Halobacterium sp.1, Halobacterium sp.2, Halobaculum sp., Halococcus saccharolyticus, Halorubrum saccharovorum, Haloterrigena turkmenica, Halogeometricum sp. and Natrialba sp. isolated from marine salterns around Bhavnagar coast were screened for siderophore produc...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：:Seven L. acidophilus strains were examined for their antibiotic sensitivity against various chemotherapeutic agents and all of them were found to be sensitive to novobicin, chloramphenicol, ampicillin, erythromycin, oxytetracycline and chlorotetracycline, whereas, all were resistant to norfloxacin and nalidixic acid. ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:Getting higher yields of monoclonal antibody (MAb) is a problem in Hybridoma Technology which has two major bottlenecks--(a) poor yield of hybridized cells; and (b) low cellular productivity of MAb in culture. There are three ways of obtaining high MAb yield in vitro--(a) large scale culture of hybrid cells; (b) high ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：1998-02-01 00:00:00
abstract：:gamma-Glutamyl transpeptidase (gamma-GT) activity in various organs of mice during ontogenesis has been determined. The activity profile in foetus, neonates and the adult animal were compared to ascertain the functional significance of the enzyme. In addition, the effect of cortisol on gamma-GT activity in adult kidne...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:A gene encoding beta toxin was amplified by polymerase chain reaction from C. perfringens type C isolate and cloned in pUC 19 vector. The nucleotide sequence was identical with C. perfringens type B beta toxin gene sequence. The Southern hybridization using labelled beta toxin gene probe revealed the presence of posit...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The present method involves conversion of the aldehyde produced, as a result of serotonin deamination by monoamine oxidase, to its 2:4 dinitrophenyl hydrazone derivative which gives a stable, bright yellow colour in alkaline solution and can be measured colorimetrically. The derivative is however unstable in the acidi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:Bipolar concentric electrodes were implanted in extreme lateral regions of hypothalamus having coordinates (A12.5 mm, L 3.5-3.7 mm, V 3.0-3.7 mm). These sites were electrically stimulated using biphasic square wave pulses (1 ms, 60 Hz) at a current strength ranging from 300-800 microA to evoke predatory attack on an a...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:A set of 25 Kanagawa(+) and Kanagawa(-) strains of V. parahaemolyticus was studied for their ability to degrade hydrocarbons in minimal media. All strains gave positive results with respect to crystal violet (CV), methyl violet, liquid paraffin, benzene, naphthalene and phenol. The CV double ring (CVDR) response had e...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:Ovine LH is needed for differentiation of juvenile Leydig cells and for their maintenance and steroidogenic potential, while FSH is necessary for Sertoli cell activity and spermatogonial multiplication suggesting that LH is steroidogenic hormone and FSH is gametogenic in the developing pigeon, C. livia. Homoplastic pi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Stress is often associated with water retention and its resolution with diuresis. The biological systems for the control of stress and water balance are very closely related. Corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) are co-localised in the hypothalamus and often act synergistically. Atrial...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：1998-12-01 00:00:00
abstract：:Four heterocystous cyanobacteria, isolated from grasslands of Ujjain were selected to prepare the clay based inoculants. Inoculants were evaluated for shelf life in terms of the titer value at 6 month intervals for 24 months. For colonization by inoculants in natural grasslands, the clay based inocula were applied to ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：:Protective effect of sex steroid hormones on aflatoxin-induced cytotoxicity on RBC (hemolysis) was examined in vitro. Addition of aflatoxin (2 micrograms/ml) in RBC suspension caused significant increase in hemolysis. Concurrent addition of aflatoxin (2 micrograms/ml) and estradiolbenzoate (100-1200 pg/ml) in RBC susp...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:The alkaloids from the ethanolic extract of H. antidysenterica seeds were evaluated for their antibacterial activity against clinical isolates of enteropathogenic Escherichia coli (EPEC) in vitro, and their antidiarrhoeal activity on castor oil-induced diarrhoea in rats, in vivo. The plasmid DNA, whole cell lysate and...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:The 50% ethanolic extract of the root bark of C. odorata administered orally at the dose of 1g/kg body weight/day for 60 days resulted in decreased epididymal sperm motility and sperm count in male albino rats. Morphological abnormalities were also observed in the sperms. The testicular glycogen, the activities of 3be...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：:Stocks of three Indian Chandipura virus (CHPV) isolates; one isolate from an adult febrile case in 1965 from Chandipura town, Maharashtra, and two isolates from two pediatric encephalitis cases from Andhra Pradesh, 2003 were inoculated in 10-day-old chick embryos by allantoic route. All three virus isolates replicated...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：:The present study on a defined deletion aroA mutant (B-26) of Salmonella enterica subspecies enterica serovar Abortusequi (S. Abortusequi) for residual virulence and safety in experimental model revealed that the virulence of the strain was at no difference in any of the cell assays (caprine alveolar macrophages, bovi...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：:Dementia is one of the age related mental problems and a characteristic symptom of various neurodegenerative disorders including Alzheimer's disease. Certain drugs like diazepam, barbiturates and alcohol disrupt learning and memory in animals and man. However, a new class of drugs known as nootropic agents is now used...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：:Influence of piroxicam (PX) on glibenclamide (GL) induced hypoglycemia has been studied in rats, healthy human volunteers and diabetics. GL per se has significantly reduced blood sugar levels in rats and in humans. PX per se has significantly reduced BSLs, in diabetics, while having no significant influence on blood s...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Cells and organisms exposed to detrimental and toxic substances show different responses in photon emission dependent on amount, kind and exposure time of toxin as well as on the organism investigated. Radical reaction-generating substances and dehydrating, lipid dissolving and protein denaturating toxins which do not...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:Valeriana officinalis is an important medicinal herb commonly found in Kashmir valley. This study forms an important preliminary step for in-vitro micro propagation of V. officinalis from breaking the seed dormancy, inducing rapid seed germination and its subsequent micro propagation. We investigated the influence of ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：:Radiosensitizing effects of combination of a minor groove DNA ligand, Hoechst-33342, with the glucose analogue and inhibitor of glycolysis, 2-deoxy-D-glucose (2-DG) have been investigated in Ehrlich ascites tumour (EAT) bearing mice following focal irradiation of the tumour with 60Co gamma-rays. Treatment-induced tumo...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Cisplatin-based chemotherapy has a variety of vascular side effects. The aim of the present study was to evaluate the beneficial effect of melatonin and cisplatin on the alterations in vascular reactivity and structure of cisplatin-treated rats. Phenylephrine (PHE) and KCl-caused concentration-dependent contractions o...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：:The present study evaluates effect of pharmacokinetic interaction between caffeine (300 mg) in three divided doses with sodium valproate (400 mg) and carbamazepine (200 mg) given as single doses, in normal human volunteers, using a open cross over design. Both the serum concentration of sodium valproate and pharmacoki...
journal_title：Indian journal of experimental biology
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-01-01 00:00:00
