Steroid hormones retard aflatoxin-induced cytotoxicity.

Abstract:

:Protective effect of sex steroid hormones on aflatoxin-induced cytotoxicity on RBC (hemolysis) was examined in vitro. Addition of aflatoxin (2 micrograms/ml) in RBC suspension caused significant increase in hemolysis. Concurrent addition of aflatoxin (2 micrograms/ml) and estradiolbenzoate (100-1200 pg/ml) in RBC suspension significantly retarded aflatoxin-induced hemolysis. Similarly, addition of aflatoxin (2 micrograms/ml) along with testosterone propionate (5-60 ng/ml) in RBC suspension retarded aflatoxin-induced hemolysis. Among the two synthetic hormones studied estradiolbenzoate was more potent than testosterone propionate.

journal_name

Indian J Exp Biol

authors

Raval PJ,Verma RJ

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

780-1

issue

9

eissn

0019-5189

issn

0975-1009

journal_volume

31

pub_type

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