Effect of uric acid on sodium oxalate-induced urolithiasis in rats--biochemical and histological evidences.

Abstract:

:Effect of uric acid on sodium oxalate-induced biochemical and histological changes were studied in rats. Rats injected with sodium oxalate (0.7 mg/100 g body wt, ip) show calcium deposits in the lumen of kidney tubules. Uric acid administration was found to potentiate calcium oxalate calculi formation. Lipid peroxide formation was increased up to 100% in kidney and 28% in liver by sodium, oxalate treatment. Uric acid administration was found to reduce lipid peroxide level up to 12% in liver and 20% in kidney. From this study it is concluded that lipid peroxidation may not be the cause of sodium oxalate-induced urolithiasis and the results are discussed with reference to the epitaxic nature of uric acid on kidney stone formation.

journal_name

Indian J Exp Biol

authors

Poonkuzhali B,Saraswathi CP,Rajalakshmi K

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

20-4

issue

1

eissn

0019-5189

issn

0975-1009

journal_volume

32

pub_type

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