Abstract:
:Muktashukti bhasma (MSB), an Ayurvedic compound, consisting of pearl, Aloe vera and vinegar, inhibited acute and subacute inflammation in albino rats as induced by subplanter injection of carrageenan, histamine, 5-HT, nystatin and subcutaneous implant of cotton pellets. In all the test procedures the antiinflammatory response of 1000 mg/kg MSB was comparable to the response observed with 300 mg/kg acetylsalicylic acid (ASA). Oral premedication with MSB delayed castor oil-induced diarrhoea in rats, indicating its prostaglandin inhibitory activity. The antiinflammatory activity of the compound is attributed to its ability to cause inhibition of prostaglandins, histamine and 5-HT and also by stabilization of the lysosomal membranes. The antiinflammatory activity of MSB seems one third to half as potent as ASA.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Chauhan O,Godhwani JL,Khanna NK,Pendse VKkeywords:
subject
Has Abstractpub_date
1998-10-01 00:00:00pages
985-9issue
10eissn
0019-5189issn
0975-1009journal_volume
36pub_type
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