Antiinflammatory activity of Muktashukti bhasma.

Abstract:

:Muktashukti bhasma (MSB), an Ayurvedic compound, consisting of pearl, Aloe vera and vinegar, inhibited acute and subacute inflammation in albino rats as induced by subplanter injection of carrageenan, histamine, 5-HT, nystatin and subcutaneous implant of cotton pellets. In all the test procedures the antiinflammatory response of 1000 mg/kg MSB was comparable to the response observed with 300 mg/kg acetylsalicylic acid (ASA). Oral premedication with MSB delayed castor oil-induced diarrhoea in rats, indicating its prostaglandin inhibitory activity. The antiinflammatory activity of the compound is attributed to its ability to cause inhibition of prostaglandins, histamine and 5-HT and also by stabilization of the lysosomal membranes. The antiinflammatory activity of MSB seems one third to half as potent as ASA.

journal_name

Indian J Exp Biol

authors

Chauhan O,Godhwani JL,Khanna NK,Pendse VK

keywords:

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

985-9

issue

10

eissn

0019-5189

issn

0975-1009

journal_volume

36

pub_type

杂志文章
  • Racial divergence of a rare laboratory-evolved centromeric fission Cytorace of nasuta-albomicans complex of Drosophila.

    abstract::Fissioncytorace-1, a member of the nasuta-albomicans complex of Drosophila is an evolutionary product of centric fission, which had occurred in the chromosome X3 of Cytorace 1, a hydridization product of Drosophila nasuta nasuta male (2n=8) and Drosophila nasuta albomicans female (2n=6). Cytorace 1 (males 2n=7; female...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Bijaya T,Ramachandra NB

    更新日期:2010-05-01 00:00:00

  • Cholesterol mediated changes in beta-glucuronidase activities of rat theca interstitial cells and granulosa cells.

    abstract::Effects of steroid hormones on beta-glucuronidase activities of granulosa cells and theca interstitial cells were studied in vitro in the presence and absence of cholesterol in minimum essential medium (MEM with Hank's salts). Conspicuous fall in the enzyme activities of both these cells were noticed during first 10 m...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Patil S,Kanase A

    更新日期:1995-05-01 00:00:00

  • Stereological study of rat spleen following acute ethanol treatment.

    abstract::To investigate the acute effect of ethanol (4 g/kg, i.p.) on spleen adult female Wistar rats were treated intraperitoneally with: a) ethanol (4 g/kg body wt), b) naltrexone (5 mg/kg body wt) followed 45 minutes later by ethanol (4 g/kg body wt) and c) naltrexone (5 mg/kg body wt) alone. Untreated and saline-treated ra...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Budec M,Milićević Z,Koko V

    更新日期:2000-05-01 00:00:00

  • Adrenergic influence of uterine muscle contractions stimulated by a glycoside from the root of Dalbergia saxatilis.

    abstract::The mechanism of uterine muscle contraction stimulated by a triterpenoid glycoside (dalsaxin) isolated from the root of D. saxatilis was investigated by in vitro methods in the rat. Dalsaxin caused a dose-related increase in uterine muscle contraction. The contraction was single and transient and was abolished by mode...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Uchendu CN,Leek BF

    更新日期:1999-04-01 00:00:00

  • Identification and glycobiological characterization of circulating immune complexes in patients with visceral leishmaniasis and post kala azar dermal leishmaniasis.

    abstract::Here, we investigated the quantitative and qualitative differences in antibody classes and subclasses in serum immune complexes (ICs) of Visceral Leishmaniasis (VL), Post Kala-azar Dermal Leishmaniasis (PKDL) and different cross reactive diseases like Malaria, Leprosy, Vitiligo as compared to control subjects. IC leve...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Datta S,Modak D,Sarkar S,Saha B,Mukhopadhyay S

    更新日期:2015-06-01 00:00:00

  • Discrimination of transport systems of L-tyrosine in mouse mammary gland: characterization of system T.

    abstract::On the basis of inhibition analysis, tyrosine uptake in mouse mammary gland was found to be mediated by Na(+)-dependent and Na(+)-independent systems. Na(+)-dependent system was insensitive to 2-(methylamino) isobutyric acid (MeAIB), with an apparent Km of 1.67 mM and maximal velocity 74.5 nmol.g-1 cell. min-1. Compet...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Rekha,Kansal VK

    更新日期:1996-08-01 00:00:00

  • Targeting folate metabolism for therapeutic option: A bioinformatics approach.

    abstract::Lymphatic filariasis, commonly called elephantiasis, poses a burden of estimated level of 5.09 million disability adjusted life year. Limitations of its sole drug, diethylcarbamazine (DEC) drive exploration of effective filarial target. A few plant extracts having polyphenolic ingredients and some synthetic compounds ...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Hande S,Goswami K,Sharma R,Bhoj P,Jena L,Reddy MV

    更新日期:2015-11-01 00:00:00

  • Effect of titanium exposure on embryonic development during pre-implantation period in rats.

    abstract::Doses of titanium trichloride (1/10th and 1/5th of LD50) were administered once and daily to pregnant rats to assess their effect on embryonic development. 1/5th dose of TiCl3 administered once orally on 1st, 2nd and 3rd day post-coitum. Similarly 1/10th of LD50 was administered daily. Results revealed that 1/10th LD5...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Malik B,Prakash AO,Rai M

    更新日期:2000-12-01 00:00:00

  • An improvised method of laboratory colonization of Phlebotomus papatasi, the vector of cutaneous leishmaniasis.

    abstract::A cyclic colony of P. papatasi was successfully established, using wild caught females. The major obstacle in the colonization was infestation of fungus, which was solved when bentonite, a dehydrant was mixed in the larval diet i.e., powdered and sterilized faecal pellets of rabbit. The average duration of development...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Srinivasan R,Viswam K,Panicker KN

    更新日期:1992-10-01 00:00:00

  • Peripheral blood based C-PCR assay for diagnosing extra-pulmonary tuberculosis.

    abstract::Extra pulmonary tuberculosis (EPTB) constitutes around 20% of all tuberculosis cases in India. Conventional methods are of limited use in diagnosing this form of the disease. Polymerase chain reaction (PCR) has emerged as a sensitive and specific tool for documenting the presence of Mycobacterium tuberculosis in clini...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Khosla R,Dwivedi A,Sarin BC,Sehajpal PK

    更新日期:2009-06-01 00:00:00

  • 43 kDa and 66 kDa, two blood stage antigens induce immune response in Plasmodium berghei malaria.

    abstract::The hunt for an effective vaccine against malaria still continues. Several new target antigens as candidates for vaccine design are being explored and tested for their efficacy. In the present study the sera from mice immunized with 24,000 x g fraction of Plasmodium berghei has been used to identify highly immunogenic...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Pirta C,Banyal HS

    更新日期:2014-08-01 00:00:00

  • Bioreactor operated production of lipase: castor oil hydrolysis using partially-purified lipase.

    abstract::A highly stable lipase from Pseudomonas aeruginosa KKA-5 was produced by batch cultivation technique employing shake flask and 5 L-bioreactor. The bioreactor was run at different airflow rates. Low airflow rates (1 and 3 L/min), did not lead to effective growth and lipase production. Growth increased by about one orde...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Sharon C,Nakazato M,Ogawa HI,Kato Y

    更新日期:1999-05-01 00:00:00

  • Antioxidant DL-alpha lipoic acid as an attenuator of adriamycin induced hepatotoxicity in rat model.

    abstract::Protective efficacy of DL-alpha lipoic acid on adriamycin induced hepatotoxicity was evaluated in rats. Adriamycin toxicity, induced by a single injection (ip; 15 mg/kg body wt), was expressed by an elevation in alanine transaminase, aspartate transaminase, bilirubin levels in serum and alkaline phosphatase, lactate d...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Anandakumar PP,Malarkodi SP,Sivaprasad TR,Saravanan GD

    更新日期:2007-12-01 00:00:00

  • Spirulina platensis protects neurons via suppression of glial activation and peripheral sensitization leading to restoration of motor function in collagen-induced arthritic rats.

    abstract::Spirulina platensis treatment (400 mg kg(-1) for 25 days) effectively suppressed peripheral sensitization via modulation of glial activation and improved motor coordination and restoration of functional motor activity in collagen-induced arthritic rats. Spirulina treatment also resulted in an appreciable reduction of ...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Patro N,Sharma A,Kariaya K,Patro I

    更新日期:2011-10-01 00:00:00

  • Effect of thyroid hormones on delayed type hypersensitivity reaction.

    abstract::The effect of long term administration of thyroid hormones and its deprivation on delayed type hypersensitivity (DTH) reaction to 2-4 dinitrochlorobenzene (DNCB) was studied. Animals were either pre-treated with thyroid hormones (T3 or T4) for 15 days and then subjected to DNCB skin test or the animals received thyroi...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Chandel AS,Chatterjee S

    更新日期:1989-05-01 00:00:00

  • Environmental contaminants in pathogenesis of breast cancer.

    abstract::This review is an attempt to comprehend the diverse groups of environmental chemical contaminants with a potential for pathogenesis of breast cancer, their probable sources and the possible mechanisms by which these environmental contaminants act and interplay with other risk factors. Estrogens are closely related to ...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章,评审

    doi:

    authors: Mukherjee S,Koner BC,Ray S,Ray A

    更新日期:2006-08-01 00:00:00

  • Identification of allergens in Indian fishes: hilsa and pomfret exemplified by ELISA and immunoblotting.

    abstract::Enzymed-linked immunosorbent assay of hilsa and pomfret muscle extracts showed specific IgE binding to ten allergic patients' sera, the results corroborated to that of skin prick test. Comparison of allergen profiles of the two fish extracts by immunoblotting revealed a common antigenic protein of 50 kDa and some high...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Das A,Chakraborti P,Chatterjee U,Monddal G,Chatterjee BP

    更新日期:2005-12-01 00:00:00

  • Investigations on wound healing by using amphibian skin.

    abstract::The present investigation is aimed to justify the validity of traditional practice of using the frog skin in wound healing. Studies were carried out on skin wounds from female albino rats of Wistar strain weighing 100-120 g. The wounds of standard size (5 cm2) were created in the experimental and control groups. The e...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Sai KP,Reddy PN,Babu M

    更新日期:1995-09-01 00:00:00

  • Hepatoprotective effect of coumestans isolated from the leaves of Wedelia calendulacea Less. in paracetamol induced liver damage.

    abstract::Effect of coumestans isolated form the leaves of W. calendulacea was evaluated in paracetamol induced liver damage. The increased serum enzyme levels (lactate dehydrogenase, alanine and aspartate transaminase and alkaline phophatase) by paracetamol induction were significantly lowered due to coumestans treatment. Resu...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Emmanuel S,Amalraj T,Ignacimuthu S

    更新日期:2001-12-01 00:00:00

  • Partial role of nitric oxide in infarct size limiting effect of quercetin and rutin against ischemia-reperfusion injury in normal and diabetic rats.

    abstract::Reperfusion injury is remarkable clinical issue that needs to be resolved as ischemia-reperfusion is a common phenomenon encountered in numerous clinical situations. The present communication report the involvement of nitric oxide (NO) in cardioprotection offered by flavonoids (rutin and quercetin) against myocardial ...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Challa SR,Akula A,Metla S,Gopal PN

    更新日期:2011-03-01 00:00:00

  • Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.

    abstract::Self-mutilation or self-injurious behaviour is a well known behavioural disorder in humans. The proposition that this behaviour in animals is a response to chronic pain of peripheral nerve injury has been met with controversy. In the present study a pharmacological model, which produces no sensory or motor loss was us...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Jain S,Sharma R

    更新日期:2002-11-01 00:00:00

  • Effect of fatty acid binding proteins on developing human placental malate dehydrogenase activity.

    abstract::Role of fatty acid binding proteins (FABPs) in modulating inhibition of human placental malate dehydrogenase by palmitoyl-CoA and oleate has been studied. Activity of human placental cytosolic malate dehydrogenase is detected throughout the gestation, showing a peak at midgestation (20-25 weeks). Inhibition (50%) of t...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Bandyopadhyay AK,Das T,Sa G,Mukherjea M

    更新日期:1994-11-01 00:00:00

  • A novel DNA vaccine constructed by heat shock protein 70 and melanoma antigen-encoding gene 3 against tumorigenesis.

    abstract::Melanoma antigen-encoding gene 3 (MAGE-3) is an ideal candidate for a tumor vaccine although its potency need to be increased. Heat shock proteins (HSPs) represents a potential approach for increasing the potency of DNA vaccines. In the present study, a fusion DNA vaccine composed of Mycobacterium tuberculosis HSP70 a...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Qu P,Ma JH,Zhang XM,Huang XJ,Yang XW,Yan-Fang S

    更新日期:2010-05-01 00:00:00

  • L-asparaginase activity in Aeromonas sp. isolated from freshwater mussel.

    abstract::Aeromonas sp. from Lamellidens marginalis produced L-asparaginase when grown at 37 degrees C. The optimum enzyme activity was at pH 9 when temperature was 45 degrees C. Half-life of partially purified enzyme at 50 degrees C and 55 degrees C was 35 and 20 min, respectively. Activation and deactivation energies of parti...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Pattnaik S,Kabi R,Janaki Ram K,Bhanot KK

    更新日期:2000-11-01 00:00:00

  • Changes in Na and K ions in mouse liver following in vivo exposure to ultrasound.

    abstract::Mouse liver was exposed in vivo to a continuous and unfocussed ultrasound of 875 KHz at 5, 10 or 15 W/cm2 for 300 sec spread over five days and excised on day 0, 1, 5 and 10 for studying the changes in Na+ and K+ reserves and Na-K-ATPase activity. At 5 and 10 W intensities the change in ionic concentrations and Na-K-A...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Varma BM,Nath BS,Kumar RP

    更新日期:1994-10-01 00:00:00

  • Detection of tomato leaf curl geminivirus in its vector Bemisia tabaci.

    abstract::Geminiviruses are single-stranded DNA plant infecting viruses that cause major losses in important crops in tropical and subtropical countries. Tomato leaf curl virus (TLCV) belonging to the genera Begomovirus, is a whitefly-transmitted geminivirus that causes a severe leaf curl disease in tomato (Lycopersicon esculen...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Khan JA

    更新日期:2000-05-01 00:00:00

  • Effect of streptozotocin-induced diabetes on growth and proteolytic activity of different muscles in rats.

    abstract::Fibre and non-fibre components and proteolytic activity of fore- and hindlimb muscles with different fibre composition and functions were examined in streptozotocin-induced diabetic rats. From hindlimb, extensor digitorum longus (EDL), medial gastrocnemius (MG) and soleus (SOL) were selected to represent muscles rich ...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Chaudhury SK,Mandal MB,Deshpande SB,Saxena ID

    更新日期:1994-12-01 00:00:00

  • gamma-Glutamyl transpeptidase activity in mice: age dependent changes and effect of cortisol.

    abstract::gamma-Glutamyl transpeptidase (gamma-GT) activity in various organs of mice during ontogenesis has been determined. The activity profile in foetus, neonates and the adult animal were compared to ascertain the functional significance of the enzyme. In addition, the effect of cortisol on gamma-GT activity in adult kidne...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Thusu N,Raina PN,Johri RK

    更新日期:1991-12-01 00:00:00

  • Ethanolic extract of Clerodendrum violaceum Gürke leaves enhances kidney function in mouse model of malaria.

    abstract::Evaluation of the effects of daily oral administration of ethanolic extract of C. violaceum leaves (13 mg/kg body weight) for 5 days on some kidney function indices of uninfected and Plasmodium berghei-infected mice was done on days 3, 8 and 14 post-infection. The indices studied include serum urea and creatinine conc...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Zailani AH,Balogun EA,Adebayo JO

    更新日期:2009-05-01 00:00:00

  • Potentiation of hypoglycemic response of glibenclamide by piroxicam in rats and humans.

    abstract::Influence of piroxicam (PX) on glibenclamide (GL) induced hypoglycemia has been studied in rats, healthy human volunteers and diabetics. GL per se has significantly reduced blood sugar levels in rats and in humans. PX per se has significantly reduced BSLs, in diabetics, while having no significant influence on blood s...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Diwan PV,Sastry MS,Satyanarayana NV

    更新日期:1992-04-01 00:00:00