Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice.

Abstract:

:Light microscopic study of hippocampal sub-regions demonstrated significant number of degenerated nerve cell bodies in the CA3, CA4 and dentate gyrus(Dg) areas of sodium fluoride administered adult female mice. Ultrastructural studies revealed neurodegenrative characteristics like involution of cell membranes, swelling of mitochondria, clumping of chromatin material etc, can be observed in cell bodies of CA3, CA4 and dentate gyrus (Dg). Fluoride intoxicated animals also performed poorly in motor co-ordination tests and maze tests. Inability to perform well increased with higher fluoride concentration in drinking water.

journal_name

Indian J Exp Biol

authors

Bhatnagar M,Rao P,Sushma J,Bhatnagar R

keywords:

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

546-54

issue

5

eissn

0019-5189

issn

0975-1009

journal_volume

40

pub_type

杂志文章
  • Production of hydroquinol from p-benzoquinone using yeast.

    abstract::Reduction of p-benzoquinone to hydroquinol has been studied using Saccharomyces cerevisae and S.uvarum. Maximum conversion of p-Benzoquinone (p-BQ) to Hydroquinol (HQ) at a substrate concentration of 6%. S. cerevisae was found to be better than S. uvarum. No further conversion did take place after 60 hr. Optical innoc...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Ghosh BK

    更新日期:1995-01-01 00:00:00

  • Effect of estradiol-17beta on cell area, lumen area and trehalase activity of posterior silk gland of Bombyx mori L.

    abstract::Estradiol-17beta (E2) at the dose of 1 microg/g caused an increase in cell area, lumen area and the total (cell + lumen) area of posterior silk gland (PSG) in Bombyx mori indicating that exogenously applied estradiol-17beta has a regulatory influence on silk gland activity. A dose-dependent variation in trehalase acti...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Keshan B,Ray AK

    更新日期:2001-11-01 00:00:00

  • Stress responses in two genotypes of mulberry (Morus alba L.) under NaCl salinity.

    abstract::Changes in biomass yield rates, cell membrane stability (CMS), malondialdehyde (MDA) content and in the levels of physiological stress markers such as proline and glycine betaine in two high yielding genotypes (S1 and ATP, salt tolerant and salt sensitive, respectively) of mulberry under NaCl salinity were studied. Bi...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Kumar SG,Madhusudhan KV,Sreenivasulu N,Sudhakar C

    更新日期:2000-02-01 00:00:00

  • Effect of androgens on oviductal growth in skipper frog Rana cyanophlyctis.

    abstract::Effects of exogenous androgens (testosterone, testosterone propionate and dihydrotestosterone) and estradiol-17beta on the oviductal growth/hypertrophy were studied in young and bilaterally ovariectomized (BLO) adult frogs (Rana cyanophlyctis) during postbreeding phase of the reproductive cycle. Estradiol-17beta injec...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Pancharatna K,Rajapurohit SV,Hiregoudar SR,Kumbar SM

    更新日期:2001-09-01 00:00:00

  • Effect of maternal iron deficiency on GABA shunt pathway of developing rat brain.

    abstract::Iron deficiency during pregnancy and lactation (35 mg iron/kg diet) produced a significant reduction in liver nonheme iron in dams as well as in fetus and young ones. The body, liver and brain weights of fetus, new-born, and developing pups remained unaffected. However, the body weight and PCV were reduced only in 21-...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Taneja V,Mishra KP,Agarwal KN

    更新日期:1990-05-01 00:00:00

  • A microdroplet cell culture based high frequency somatic embryogenesis system for pigeonpea, Cajanus cajan (L.) Millsp.

    abstract::A protocol for high frequency production of somatic embryos was worked out in pigeonpea, Cajanus cajan (L.) Millsp. The protocol involved sequential employment of embryogenic callus cultures, low density cell suspension cultures and a novel microdroplet cell culture system. The microdroplet cell cultures involved cult...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Kumar NU,Gnanaraj M,Sindhujaa V,Viji M,Manoharan K

    更新日期:2015-09-01 00:00:00

  • Propagation of Chandipura virus in chick embryos.

    abstract::Stocks of three Indian Chandipura virus (CHPV) isolates; one isolate from an adult febrile case in 1965 from Chandipura town, Maharashtra, and two isolates from two pediatric encephalitis cases from Andhra Pradesh, 2003 were inoculated in 10-day-old chick embryos by allantoic route. All three virus isolates replicated...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Pawar SD,Singh A,Gangodkar SV,Rao BL

    更新日期:2005-10-01 00:00:00

  • Effect of storage of blood samples on DNA yield, quality and fingerprinting: a forensic approach.

    abstract::Various storage treatments on human blood samples have been described with respect to DNA yield, quality and fingerprinting. Blood samples were stored at room temperature, 4 degrees C, -20 degrees C and -70 degrees C for different duration varying from 1, 2, 4 and 8 weeks with or without anticoagulant/preservative (ED...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Bomjen G,Raina A,Sulaiman IM,Hasnain SE,Dogra TD

    更新日期:1996-04-01 00:00:00

  • Toxicity of dimethoate on urinary hydroxyproline in rats.

    abstract::The effect of the administration of three different concentrations (2.25, 1.13 and 0.56 mg/100 g body weight) of dimethoate on the urinary excretion of total, non dialysable and free hydroxyproline were studied in female albino rats. Compared to controls, the urine contents were significantly lower in higher concentra...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Reddy PN,Raj GD,Dhar SC

    更新日期:1992-06-01 00:00:00

  • Micromanipulation and cloning studies on buffalo oocytes and embryos using nucleus transfer.

    abstract::An investigation for testing the viability of production of cloned buffalo embryos through nucleus transfer has been made. Matured buffalo oocytes, after zona cutting to an extent of 60 degrees near polar body, were enucleated using a new approach. Instead of aspirating the cytoplasm contents in a pipette, the half of...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Singla SK,Manik RS,Madan ML

    更新日期:1997-12-01 00:00:00

  • Effect of dietary fiber from banana (Musa paradisiaca) on metabolism of carbohydrates in rats fed cholesterol free diet.

    abstract::Effect of feeding isolated dietary fiber from M. paradisiaca on the metabolism of carbohydrates in the liver has been studied. Fiber fed rats showed significantly lower levels of fasting blood glucose and higher concentration of liver glycogen. Activity of glycogen phosphorylase, glucose-1-phosphate, uridyl transferas...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Usha V,Vijayammal PL,Kurup PA

    更新日期:1989-05-01 00:00:00

  • Insecticide interaction with carrier and neuroproteins.

    abstract::Binding of alpha-, beta-, gamma-hexachlorocyclohexane, p,p'-DDT and p,p'-DDE with bovine serum albumin (BSA) and locust brain homogenate was studied. Binding affinities of pesticides were higher for the locust brain homogenates than for BSA. Results of uptake by isolated locust brain revealed higher uptake of gamma-HC...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Patyal SK,Nath A

    更新日期:1992-09-01 00:00:00

  • Chronic low dose exposure to hydrogen peroxide changes sensitivity of V79 cells to different damaging agents.

    abstract::Chinese hamster V79 cells were repeatedly exposed to a low dose of hydrogen peroxide (H2O2) over several weeks and then exposed to H2O2, cisplatin or ultraviolet (UV) light. Cell killing was examined by colony formation, following these treatments. It was seen that cells conditioned by multiple low doses of H2O2 showe...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Bose K,Bhaumik G,Ghosh R

    更新日期:2003-08-01 00:00:00

  • Antilipid peroxidative property of Nardostachys jatamanasi.

    abstract::Antiperoxidative property of N. jatamanasi was tested by using iron induced lipid peroxidation in 5% rat liver homogenate. The degree of peroxidation was quantitated by thiobarbituric acid reactive substance (TBARS) content. The extract provided protection against lipid peroxidation. The hexane fraction was more poten...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Tripathi YB,Tripathi E,Upadhyay A

    更新日期:1996-11-01 00:00:00

  • Stress and water balance: the roles of ANP, AVP and isatin.

    abstract::Stress is often associated with water retention and its resolution with diuresis. The biological systems for the control of stress and water balance are very closely related. Corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) are co-localised in the hypothalamus and often act synergistically. Atrial...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章,评审

    doi:

    authors: Bhattacharya SK,Chakrabarti A,Glover V

    更新日期:1998-12-01 00:00:00

  • Gender differences in predator induced pain perception in rats.

    abstract::Pain is an unpleasant sensation. It warns the living being about the impending damage to the tissues. The perception of pain is influenced by physical and psychological factors. The impact of chronic intermittent psychological stress on pain perception and the differences in antinociceptive responses have been studied...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Sudhakar HH,Venkatesh D

    更新日期:2003-03-01 00:00:00

  • Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats.

    abstract::Present investigation was undertaken to evaluate antihyperglycemic, antihyperlipidemic and antioxidant activities of Dihar, a polyherbal formulation containing drugs from eight different herbs viz., Syzygium cumini, Momordica charantia, Emblica officinalis, Gymnema sylvestre, Enicostemma littorale, Azadirachta indica,...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Patel SS,Shah RS,Goyal RK

    更新日期:2009-07-01 00:00:00

  • Effect of preferential cyclooxygenase-2 (COX-2) inhibitor against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal lesions in rats: behavioral, biochemical and histological evidences.

    abstract::Cyclooxygenase (COX) isoenzyme is known to play an important role in the pathophysiology of Parkinson's disease. The present study evaluated the neuroprotective effect of nimesulide, a preferential COX-2-inhibitor against 1-methyl-4-phenyl-1,2,3,6-tertahydropyridine (MPTP)-model of Parkinson's disease. Intrastriatal a...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Gupta A,Dhir A,Kumar A,Kulkarni SK

    更新日期:2010-06-01 00:00:00

  • In vitro degradation of cell-wall and digestibility of cereal straws treated with anaerobic ruminal fungi.

    abstract::Ruminal fungal isolates (Orpinomyces sp.; C-14, Piromyces sp.; C-15, Orpinomyces sp.; B-13 and Anaeromyces sp.; B-6), were evaluated under anoxic conditions for their effect on in vitro dry matter digestibility, neutral detergent fibre, acid detergent fibre and acid detergent lignin using rice and wheat straw as subst...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Kumar BM,Puniya AK,Singh K,Sehgal JP

    更新日期:2004-06-01 00:00:00

  • An improvised method of laboratory colonization of Phlebotomus papatasi, the vector of cutaneous leishmaniasis.

    abstract::A cyclic colony of P. papatasi was successfully established, using wild caught females. The major obstacle in the colonization was infestation of fungus, which was solved when bentonite, a dehydrant was mixed in the larval diet i.e., powdered and sterilized faecal pellets of rabbit. The average duration of development...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Srinivasan R,Viswam K,Panicker KN

    更新日期:1992-10-01 00:00:00

  • Effect of zinc on antioxidant response in maize (Zea mays L.) leaves.

    abstract::Maize (Zea mays L. cv kanaujia) plants grown with Zn [10 (control), 0.1 (low) and 20 microM (high)], were investigated for concentration of antioxidants and activities of antioxidative enzymes in leaves. Young leaves of low Zn plants developed whitish-necrotic spots. Leaves of both low and high Zn plants showed decrea...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Pandey N,Singh AK,Pathak GC,Sharma CP

    更新日期:2002-08-01 00:00:00

  • Interrelationship between amines level in brain regions of fish, Oreochromis mossambicus during organophosphorus stress.

    abstract::Amines such as dopamine, norepinephrine and epinephrine were analysed in the brain regions of O.mossambicus exposed to quinalphos, phenthoate and their combination for 96 hr. The three types of treatments significantly (P < 0.05) altered the amines level at various intervals in the brain regions. ...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Durairaj S,Selvarajan VR,Devaraj P

    更新日期:1997-06-01 00:00:00

  • Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats.

    abstract::Treatment of full-thickness wounds with A. vera, on rats resulted in increased biosynthesis of collagen and its degradation. A corresponding increase in the urinary excretion of hydroxyproline was also observed. Elevated levels of lysyl oxidase also indicated increased crosslinking of newly synthesised collagen. The r...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Chithra P,Sajithlal GB,Chandrakasan G

    更新日期:1998-09-01 00:00:00

  • Effect of gossypol on few testicular enzymes in mature rats.

    abstract::Effect of oral administration of gossypol acetic acid (15 mg/kg/day) for 10 weeks, on certain enzymes, which may be taken as markers for the different stages of spermatogenesis, was studied in male albino rats. Gossypol produced a significant decrease in hyaluronidase and sorbitol dehydrogenase, while no change was ob...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Nair IN,Bhiwgade DA

    更新日期:1989-12-01 00:00:00

  • Targeting folate metabolism for therapeutic option: A bioinformatics approach.

    abstract::Lymphatic filariasis, commonly called elephantiasis, poses a burden of estimated level of 5.09 million disability adjusted life year. Limitations of its sole drug, diethylcarbamazine (DEC) drive exploration of effective filarial target. A few plant extracts having polyphenolic ingredients and some synthetic compounds ...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Hande S,Goswami K,Sharma R,Bhoj P,Jena L,Reddy MV

    更新日期:2015-11-01 00:00:00

  • Immunosuppression due to chronic Lantana camara, L. toxicity in sheep.

    abstract::Five sheep were intoxicated with powdered L. camara, leaves at the rate of 200 mg/kg body weight daily for 110 days and another group of four sheep were drenched with distilled water daily for equal number of days which acted as control. The cell mediated immunity of intoxicated and control sheep was assessed with the...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Ganai GN,Jha GJ

    更新日期:1991-08-01 00:00:00

  • Characterisation and starvation induced regulation of methionine uptake sites in mouse mammary gland.

    abstract::The sites of methionine uptake by 10 day lactating mouse mammary gland were determined in vitro. Four modes of methionine entry characterised were: (i) A sodium-dependent, N-(methylamino) isobutyric acid (MeAIB)--sensitive system with a Vmax of 18.8 nmol/g cells/min (this mode of entry was similar to the A site in oth...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Verma N,Kansal VK

    更新日期:1995-07-01 00:00:00

  • Impact of hypercholesterolemia on in vitro toxicity of N-nitrosodiethylamine: effect on lipidperoxidation of blood and tissue.

    abstract::In vitro treatment of erythrocytes of normal and hypercholesterolemic rats with N-nitrosodiethylamine (NDEA), an important carcinogen frequently present in human environment and food chain resulted in a marginal increase in osmotic fragility of erythrocytes without affecting their antioxygenic potential as evidenced b...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Mittal G,Kaur M,Soni G

    更新日期:2002-09-01 00:00:00

  • Partial role of nitric oxide in infarct size limiting effect of quercetin and rutin against ischemia-reperfusion injury in normal and diabetic rats.

    abstract::Reperfusion injury is remarkable clinical issue that needs to be resolved as ischemia-reperfusion is a common phenomenon encountered in numerous clinical situations. The present communication report the involvement of nitric oxide (NO) in cardioprotection offered by flavonoids (rutin and quercetin) against myocardial ...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Challa SR,Akula A,Metla S,Gopal PN

    更新日期:2011-03-01 00:00:00

  • Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action.

    abstract::Enzyme cyclooxygenase (COX) is reported to play a significant role in neurodegeneration and may play a significant role in the pathogenesis of epilepsy. Bicuculline (4 mg/kg; ip), picrotoxin (8 mg/kg; ip) and electroshock (60 mA for 0.2 sec) significantly induced convulsions in male Laka mice. COX-inhibitors viz. nime...

    journal_title:Indian journal of experimental biology

    pub_type: 杂志文章

    doi:

    authors: Dhir A,Naidu PS,Kulkarni SK

    更新日期:2006-04-01 00:00:00