Abstract：
:Betanodaviruses cause viral nervous necrosis in numerous fish species, but some species are resistant to infection by these viruses. It is essential to fully characterize the immune responses that underlie this protective response. Complete characterization of the immune responses against nodaviruses may allow the development of methods that stimulate fish immunity and of an effective betanodavirus vaccine. Such strategies could include stimulation of specific immune system responses or blockage of factors that decrease the immune response. The innate immune system clearly provides a front-line defense, and this includes the production of interferons and other cytokines. Interferons that are released inside infected cells and that suppress viral replication may be the most ancient form of innate immunity. This review focuses on the immune responses of fish to betanodavirus infection.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Chen YM,Wang TY,Chen TYdoi
10.1016/j.dci.2013.07.019subject
Has Abstractpub_date
2014-04-01 00:00:00pages
174-83issue
2eissn
0145-305Xissn
1879-0089pii
S0145-305X(13)00208-5journal_volume
43pub_type
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