Antivirals in seasonal and pandemic influenza--future perspectives.

abstract：BACKGROUND:In Ireland, horses may be protected against equine influenza virus (EIV) as a result of natural exposure or vaccination. Current mandatory vaccination programmes are targeted at highly mobile horses. A correlation between antibody levels as measured by single radial haemolysis (SRH) and protective immunity a...

journal_title：Influenza and other respiratory viruses

authors： Gildea S,Arkins S,Cullinane A

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Influenza vaccine coverage rates among healthcare workers (HCWs) in acute care facilities in Canada remain below national targets. OBJECTIVE:To determine factors associated with influenza vaccine uptake among HCWs. METHODS:This secondary analysis of a prospective cohort study included HCWs aged 18-69 years...

journal_title：Influenza and other respiratory viruses

authors： Hussain H,McGeer A,McNeil S,Katz K,Loeb M,Simor A,Powis J,Langley J,Muller M,Canadian Health Care Worker Study Group.,Coleman BL

更新日期：2018-05-01 00:00:00

abstract：:An outbreak of highly pathogenic avian influenza A (H5N6) virus occurred between November 20, 2016, and March 1, 2017 in poultry farms, in the Gyeonggi Province, Republic of Korea. To identify the risk of transmission of H5N6 to depopulation workers, active and passive surveillance was conducted. Virological testing o...

journal_title：Influenza and other respiratory viruses

authors： Ryu S,Lim JS,Cowling BJ,Chun BC

更新日期：2018-05-01 00:00:00

abstract：:Progress in the development of antivirals for non-influenza respiratory viruses has been slow with the result that many unmet medical needs and few approved agents currently exist. This commentary selectively reviews examples of where specific agents have provided promising clinical benefits in selected target populat...

journal_title：Influenza and other respiratory viruses

authors： Hayden FG

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The new influenza virus A/H1N1 (2009), identified in mid-2009, rapidly spread over the world. Estimating the transmissibility of this new virus was a public health priority. METHODS:We reviewed all studies presenting estimates of the serial interval or generation time and the reproduction number of the A/H1...

journal_title：Influenza and other respiratory viruses

authors： Boëlle PY,Ansart S,Cori A,Valleron AJ

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Patient-reported outcomes (PROs) are particularly relevant in influenza vaccine trials in the elderly where reduction in symptom severity could prevent illness-related functional impairment. OBJECTIVES:To evaluate PROs in people aged ≥ 65 years receiving two different vaccines. METHODS:This was a phase III...

journal_title：Influenza and other respiratory viruses

authors： van Essen GA,Beran J,Devaster JM,Durand C,Duval X,Esen M,Falsey AR,Feldman G,Gervais P,Innis BL,Kovac M,Launay O,Leroux-Roels G,McElhaney JE,McNeil S,Oujaa M,Richardus JH,Ruiz-Palacios G,Osborne RH,Oostvogels L

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:It appears inter-seasonal influenza notifications have been increasing in summer months in Australia. This study aims to determine changes in inter-seasonal influenza activity in Australia over time. METHODS:Routine influenza surveillance data and hospitalisations data were analysed to study the epidemiolog...

journal_title：Influenza and other respiratory viruses

authors： Moa AM,Adam DC,MacIntyre CR

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The Northern Territory (NT) of Australia has a mix of climates, sparsely distributed population and a large proportion of the populace are Indigenous Australians, and influenza is known to have a disproportionate impact upon this group. Understanding the epidemiology of influenza in this region would inform ...

journal_title：Influenza and other respiratory viruses

authors： Weinman AL,Sullivan SG,Vijaykrishna D,Markey P,Levy A,Miller A,Tong SYC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) is an important cause of medically attended acute respiratory illnesses in older adults but awareness of the relevance of RSV in older people remains lower than that of influenza, which exhibits similar clinical characteristics to those of RSV. OBJECTIVES:This study was per...

journal_title：Influenza and other respiratory viruses

authors： Zhang Y,Wang Y,Zhao J,Xiong Z,Fan Y,Zhang W,Zou X,Wang C,Han J,Li B,Lu B,Cao B,CAP-China Network.

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Respiratory protective devices are critical in protecting against infection in healthcare workers at high risk of novel 2019 coronavirus disease (COVID-19); however, recommendations are conflicting and epidemiological data on their relative effectiveness against COVID-19 are limited. PURPOSE:To compare medi...

journal_title：Influenza and other respiratory viruses

authors： Bartoszko JJ,Farooqi MAM,Alhazzani W,Loeb M

更新日期：2020-07-01 00:00:00

abstract：:Influenza antiviral drugs are important for the control of influenza, most specifically for the treatment of influenza patients with severe disease following infection with a seasonal influenza virus, a newly emerging influenza strain, or in the event of a pandemic. Many influenza antivirals that are currently under i...

journal_title：Influenza and other respiratory viruses

authors： Koszalka P,Tilmanis D,Hurt AC

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:A single case of novel influenza A (H1N1) 09 infection was identified by PCR among a New Zealand high-school group that toured California in April 2009. Close monitoring of the tour group and their New Zealand contacts identified 11 other tour members with respiratory symptoms who were investigated. In all n...

journal_title：Influenza and other respiratory viruses

authors： Mardani J,Calder L,Laurie K,Barr I,Kelso A,Jones N

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Several studies have demonstrated the role of meteorological parameters in the seasonality of influenza viruses in tropical and subtropical regions, most importantly temperature, humidity, and rainfall. OBJECTIVES:This study aimed to describe the influence of meteorological parameters in the seasonality of ...

journal_title：Influenza and other respiratory viruses

authors： Munshili Njifon HL,Monamele CG,Kengne Nde C,Vernet MA,Bouba G,Tchatchouang S,Njankouo MR,Tapondjou R,Deweerdt L,Mbacham W,Njouom R

更新日期：2019-03-01 00:00:00

abstract：:We consider the net benefits of pre-dispensing antivirals to high-risk individuals during an influenza pandemic, where the measure of the benefit is the number of severe outcomes (such as deaths or hospitalizations) prevented by antivirals in the whole population. One potential benefit of pre-dispensing is that indivi...

journal_title：Influenza and other respiratory viruses

authors： Goldstein E,Miller JC,O'Hagan JJ,Lipsitch M

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Whether morbidity from the 1918-19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue, the recent literature has hypothesized that morbidity was "socially neutral." OBJECTIVES:To study the associations between influenz...

journal_title：Influenza and other respiratory viruses

authors： Mamelund SE

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Data about influenza mortality burden in northern China are limited. This study estimated mortality burden in Beijing associated with seasonal influenza from 2007 to 2013 and the 2009 H1N1 pandemic. METHODS:We estimated influenza-associated excess mortality by fitting a negative binomial model using weekly ...

journal_title：Influenza and other respiratory viruses

authors： Wu S,Wei Z,Greene CM,Yang P,Su J,Song Y,Iuliano AD,Wang Q

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Influenza A(H3N2), A(H1N1)pdm09 and B viruses co-circulated in Europe in 2017-18, predominated by influenza B. WHO-recommended, trivalent vaccine components were lineage-mismatched for B. The I-MOVE hospital network measured 2017-18 seasonal influenza vaccine effectiveness (IVE) against influenza A(H3N2) and...

journal_title：Influenza and other respiratory viruses

authors： Rose AMC,Kissling E,Gherasim A,Casado I,Bella A,Launay O,Lazăr M,Marbus S,Kuliese M,Syrjänen R,Machado A,Kurečić Filipović S,Larrauri A,Castilla J,Alfonsi V,Galtier F,Ivanciuc A,Meijer A,Mickiene A,Ikonen N,Gómez

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The 2009 pandemic H1N1 (A(H1N1)pdm09) influenza A virus (IAV) has replaced the previous seasonal H1N1 strain in humans and continues to circulate worldwide. The comparative performance of inactivated A(H1N1)pdm09 influenza vaccines remains of considerable interest. The objective of this study was to evaluate...

journal_title：Influenza and other respiratory viruses

authors： Vidaña B,Brookes SM,Everett HE,Garcon F,Nuñez A,Engelhardt O,Major D,Hoschler K,Brown IH,Zambon M

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:During April-July 2009, U.S. hospitalization rates for 2009 pandemic influenza A (H1N1) virus (H1N1pdm09) infection were estimated at 4·5/100 000 persons. We describe rates and risk factors for H1N1pdm09 infection among American Indians (AIs) in four isolated southwestern U.S. communities served by the India...

journal_title：Influenza and other respiratory viruses

authors： Suryaprasad A,Redd JT,Hancock K,Branch A,Steward-Clark E,Katz JM,Fry AM,Cheek JE,Influenza Serology Working Group.,American Indian and Alaska Native Pandemic Influenza A (H1N1) Investigation Team.

更新日期：2013-11-01 00:00:00

abstract：:The emergence of a novel swine-origin pandemic influenza virus in 2009, together with the continuing circulation of highly pathogenic avian H5N1 viruses and the urgent global need to produce effective vaccines against such public health threats, has prompted a renewed interest in improving our understanding of the imm...

journal_title：Influenza and other respiratory viruses

authors： Haaheim LR,Katz JM

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Recent outbreaks of highly pathogenic avian influenza and multiple occurrences of zoonotic infection and deaths in humans have sparked a dramatic increase in influenza research. In order to rapidly identify and help prevent future influenza outbreaks, numerous laboratories around the world are working to dev...

journal_title：Influenza and other respiratory viruses

authors： Bose ME,Littrell JC,Patzer AD,Kraft AJ,Metallo JA,Fan J,Henrickson KJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Since 2009, Thailand has recommended influenza vaccine for children aged 6 months through 2 years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group. METHODS:During August 2011-May 2013, high-risk and healthy children aged ≤36 months were enrolled in a 2-yea...

journal_title：Influenza and other respiratory viruses

authors： Kittikraisak W,Suntarattiwong P,Levy J,Fernandez S,Dawood FS,Olsen SJ,Chotpitayasunondh T

更新日期：2015-03-01 00:00:00

abstract：:A myriad of risk factors have been linked to an increase in the severity of the pandemic H1N1 2009 influenza A virus [A(H1N1)pdm09] including pregnancy and obesity where death rates can be elevated as compared to the general population. The goal of this review is to provide an overview of the influence of pregnancy an...

journal_title：Influenza and other respiratory viruses

authors： Karlsson EA,Marcelin G,Webby RJ,Schultz-Cherry S

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The 1918 influenza pandemic caused disproportionately high mortality among certain age groups. The mechanisms underlying these differences are not fully understood. OBJECTIVES:To explore the dynamics of the 1918 pandemic and to identify potential age-specific transmission patterns. METHODS:We examined 1915...

journal_title：Influenza and other respiratory viruses

authors： Yang W,Petkova E,Shaman J

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Wild birds are the natural hosts for influenza A viruses (IAVs) and provide a niche for the maintenance of this virus. OBJECTIVES:This study was undertaken to analyze nucleotide sequences of the matrix (M) gene of AIVs isolated from wild birds and live bird markets (LBMs) to index the changes occurring in t...

journal_title：Influenza and other respiratory viruses

authors： Chander Y,Jindal N,Sreevatsan S,Stallknecht DE,Goyal SM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:A candidate pandemic influenza H5N1 vaccine should provide rapid and long-lasting immunity against antigenically drifted viruses. As H5N1 viruses are poorly immunogenic, this may require a combination of immune potentiating strategies. An attractive approach is combining the intrinsic immunogenicity of viros...

journal_title：Influenza and other respiratory viruses

authors： Pedersen G,Major D,Roseby S,Wood J,Madhun AS,Cox RJ

更新日期：2011-11-01 00:00:00

abstract：:The aim of this study was to investigate the rate of transmission of respiratory viral infections to children visiting the emergency room of a large pediatric hospital during winter. A total of 615 children were prospectively studied. Twenty-two (3·6%) children developed at least one symptom compatible with a respirat...

journal_title：Influenza and other respiratory viruses

authors： Maltezou HC,Mougkou K,Asimaki H,Koniaraki K,Katerelos P,Giannaki M,Theodoridou M

更新日期：2013-01-01 00:00:00

abstract：:Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA have been detected in some individuals following treatment. Here, we d...

journal_title：Influenza and other respiratory viruses

authors： Koszalka P,Farrukee R,Mifsud E,Vijaykrishna D,Hurt AC

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The genetic and antigenic characteristics of influenza A viruses (IAV) within and between species change over time due to antigenic shift and drift. Although pigs are known to play a key role in the epidemiology of IAV between species, little is known about the molecular evolution of IAV hemagglutinin (HA) i...

journal_title：Influenza and other respiratory viruses

authors： Diaz A,Allerson M,Culhane M,Sreevatsan S,Torremorell M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Antibodies to neuraminidase (NA) contribute to protection during influenza virus infection, but NA inhibition (NI) titers are not routinely analyzed in vaccine trials. One reason is the cumbersome nature of the conventional thiobarbituric acid (TBA) NI assay, which uses chemical methods to quantify free sial...

journal_title：Influenza and other respiratory viruses

authors： Sandbulte MR,Gao J,Straight TM,Eichelberger MC

更新日期：2009-09-01 00:00:00