Abstract:
:Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA have been detected in some individuals following treatment. Here, we describe a genotypic pyrosequencing method that can be used to rapidly screen circulating influenza A and B viruses for substitutions in the PA/I38 codon and to quantify mixed viral populations. This method is suitable for surveillance of baloxavir susceptibility and to analyse samples from hospitalised patients undergoing baloxavir treatment to aid in clinical decision making.
journal_name
Influenza Other Respir Virusesjournal_title
Influenza and other respiratory virusesauthors
Koszalka P,Farrukee R,Mifsud E,Vijaykrishna D,Hurt ACdoi
10.1111/irv.12725subject
Has Abstractpub_date
2020-07-01 00:00:00pages
460-464issue
4eissn
1750-2640issn
1750-2659journal_volume
14pub_type
杂志文章abstract::Influenza antiviral drugs are important for the control of influenza, most specifically for the treatment of influenza patients with severe disease following infection with a seasonal influenza virus, a newly emerging influenza strain, or in the event of a pandemic. Many influenza antivirals that are currently under i...
journal_title:Influenza and other respiratory viruses
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pub_type: 杂志文章,评审
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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pub_type: 历史文章,杂志文章
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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