Abstract:
BACKGROUND:Guillain-Barre syndrome (GBS) is a rare autoimmune disease characterized by acute, progressive peripheral neuropathy and is commonly associated with the presence of antiganglioside antibodies. Previously, influenza vaccination was linked with the increased incidence of GBS; however, whether antiganglioside antibodies are subsequently induced remains unresolved. METHODS:Sera from human subjects vaccinated with seasonal influenza vaccines from the 2007-2008, 2008-2009, or 1976-1977 influenza seasons were screened for the induction of immunity to influenza and the presence of antiganglioside antibodies pre- and post-vaccination. Likewise, sera from mice vaccinated with seasonal influenza vaccines (1988-1989, 2007-2008) or "swine flu" pandemic vaccines (1976, 2009) were assessed in the same manner. Viruses were also screened for cross-reacting ganglioside epitopes. RESULTS:Antiganglioside antibodies were found to recognize influenza viruses; this reactivity correlated with virus glycosylation. Antibodies to influenza viruses were detected in human and mouse sera, but the prevalence of antiganglioside antibodies was extremely low. CONCLUSIONS:Although the correlation between antiganglioside antibody cross-reactivity and glycosylation of viruses suggests the role of shared carbohydrate epitopes, no correlation was observed between hemagglutinin-inhibition titers and the induction of antiganglioside antibodies after influenza vaccination.
journal_name
Influenza Other Respir Virusesjournal_title
Influenza and other respiratory virusesauthors
Wang DJ,Boltz DA,McElhaney J,McCullers JA,Webby RJ,Webster RGdoi
10.1111/j.1750-2659.2011.00294.xsubject
Has Abstractpub_date
2012-05-01 00:00:00pages
159-66issue
3eissn
1750-2640issn
1750-2659journal_volume
6pub_type
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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更新日期:2013-05-01 00:00:00
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更新日期:2009-01-01 00:00:00
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