Abstract:
:A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole-genome sequencing of 77 influenza A(H1N1)pdm09 viruses from Moscow and Saint Petersburg. Most of the viruses were antigenically related to the vaccine strain. Whole-genome analysis revealed a composition of specific mutations in the internal genes (D2E and M83I in NEP, E125D in NS1, M105T in NP, Q208K in M1, and N204S in PA-X) that probably emerged before the beginning of 2015/2016 epidemic season.
journal_name
Influenza Other Respir Virusesjournal_title
Influenza and other respiratory virusesauthors
Komissarov A,Fadeev A,Sergeeva M,Petrov S,Sintsova K,Egorova A,Pisareva M,Buzitskaya Z,Musaeva T,Danilenko D,Konovalova N,Petrova P,Stolyarov K,Smorodintseva E,Burtseva E,Krasnoslobodtsev K,Kirillova E,Karpova L,Eropkdoi
10.1111/irv.12389subject
Has Abstractpub_date
2016-07-01 00:00:00pages
247-53issue
4eissn
1750-2640issn
1750-2659journal_volume
10pub_type
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