A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine.

abstract：BACKGROUND:We determined influenza A(H1N1)pdm09 antibody levels before and after the first wave of the pandemic in an urban community in Dhaka, Bangladesh. METHODS:We identified a cohort of households by stratified random sampling. We collected baseline serum specimens during July-August 2009, just prior to the initia...

journal_title：Influenza and other respiratory viruses

authors： Nasreen S,Rahman M,Hancock K,Katz JM,Goswami D,Sturm-Ramirez K,Holiday C,Jefferson S,Branch A,Wang D,Veguilla V,Widdowson MA,Fry AM,Brooks WA

更新日期：2017-09-01 00:00:00

abstract：:This study used Poisson regression modelling to estimate influenza-associated mortality in New Zealand for 1990-2008. Inputs were weekly numbers of deaths and influenza and RSV isolates. Seasonal influenza was associated with an average of 401 medical deaths annually from 1990 to 2008, a rate of 10.6 (95% CI: 7.9, 13....

journal_title：Influenza and other respiratory viruses

authors： Kessaram T,Stanley J,Baker MG

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Lower respiratory tract illness is a major cause of morbidity and mortality in children worldwide, however, information about the epidemiological and clinical characteristics of LRTIs caused by HMPV and HBoV in China is limited. OBJECTIVES:Human bocavirus (HBoV) and human metapneumovirus (HMPV) are two impo...

journal_title：Influenza and other respiratory viruses

authors： Zhou JY,Peng Y,Peng XY,Gao HC,Sun YP,Xie LY,Zhong LL,Duan ZJ,Xie ZP,Cao YD

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:The new influenza virus A/H1N1 (2009), identified in mid-2009, rapidly spread over the world. Estimating the transmissibility of this new virus was a public health priority. METHODS:We reviewed all studies presenting estimates of the serial interval or generation time and the reproduction number of the A/H1...

journal_title：Influenza and other respiratory viruses

authors： Boëlle PY,Ansart S,Cori A,Valleron AJ

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Influenza and other respiratory infections cause excess winter morbidity in children. This study assessed the economic impact of influenza-like illness (ILI) on families with children attending childcare using a societal perspective. METHODS:We conducted a prospective cohort study in 90 childcare centres an...

journal_title：Influenza and other respiratory viruses

authors： Yin JK,Salkeld G,Lambert SB,Dierig A,Heron L,Leask J,Yui Kwan Chow M,Booy R

更新日期：2013-11-01 00:00:00

abstract：AIM:To determine factors associated with severe hospitalized Respiratory syncytial virus (RSV)-associated LRTI and to describe management in tertiary care center. METHODS:Retrospective medical record review was conducted among children under 5 years old hospitalized with RSV-associated LRTI at King Chulalongkorn Memor...

journal_title：Influenza and other respiratory viruses

authors： Aikphaibul P,Theerawit T,Sophonphan J,Wacharachaisurapol N,Jitrungruengnij N,Puthanakit T

更新日期：2021-01-01 00:00:00

abstract：:Oseltamivir-resistant 2009 H1N1 influenza virus infections associated with neuraminidase (NA) H275Y have been identified sporadically. Strains possessing the hemagglutinin (HA) D222G mutation have been detected in small numbers of fatal 2009 H1N1 cases. We report the first clinical description of 2009 H1N1 virus infec...

journal_title：Influenza and other respiratory viruses

authors： DeVries A,Wotton J,Lees C,Boxrud D,Uyeki T,Lynfield R

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:It appears inter-seasonal influenza notifications have been increasing in summer months in Australia. This study aims to determine changes in inter-seasonal influenza activity in Australia over time. METHODS:Routine influenza surveillance data and hospitalisations data were analysed to study the epidemiolog...

journal_title：Influenza and other respiratory viruses

authors： Moa AM,Adam DC,MacIntyre CR

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Wild birds are the natural hosts for influenza A viruses (IAVs) and provide a niche for the maintenance of this virus. OBJECTIVES:This study was undertaken to analyze nucleotide sequences of the matrix (M) gene of AIVs isolated from wild birds and live bird markets (LBMs) to index the changes occurring in t...

journal_title：Influenza and other respiratory viruses

authors： Chander Y,Jindal N,Sreevatsan S,Stallknecht DE,Goyal SM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Acute respiratory infections (ARIs) are a major cause of morbidity and mortality worldwide. Influenza typically contributes substantially to the burden of ARI, but only limited data are available on influenza activity and seasonality in Jordan. METHODS:Syndromic case definitions were used to identify indivi...

journal_title：Influenza and other respiratory viruses

authors： Al-Abdallat M,Dawson P,Haddadin AJ,El-Shoubary W,Dueger E,Al-Sanouri T,Said MM,Talaat M

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Antibodies to neuraminidase (NA) contribute to protection during influenza virus infection, but NA inhibition (NI) titers are not routinely analyzed in vaccine trials. One reason is the cumbersome nature of the conventional thiobarbituric acid (TBA) NI assay, which uses chemical methods to quantify free sial...

journal_title：Influenza and other respiratory viruses

authors： Sandbulte MR,Gao J,Straight TM,Eichelberger MC

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Influenza-associated myositis (IAM), characterized by severe lower-extremity myalgia and reluctance to walk, is a complication of influenza among children. We investigated IAM in Nebraska during six influenza seasons, 2001-2007. METHODS:During 2006-2007, we requested reports of severe influenza illness among...

journal_title：Influenza and other respiratory viruses

authors： Buss BF,Shinde VM,Safranek TJ,Uyeki TM

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:A candidate pandemic influenza H5N1 vaccine should provide rapid and long-lasting immunity against antigenically drifted viruses. As H5N1 viruses are poorly immunogenic, this may require a combination of immune potentiating strategies. An attractive approach is combining the intrinsic immunogenicity of viros...

journal_title：Influenza and other respiratory viruses

authors： Pedersen G,Major D,Roseby S,Wood J,Madhun AS,Cox RJ

更新日期：2011-11-01 00:00:00

abstract：:The aim of this review was to identify factors predicting actual or intended adherence to antivirals as treatment or prophylaxis for influenza. Literature from inception to March 2015 was systematically reviewed to find studies reporting predictors of adherence to antivirals and self-reported reasons for non-adherence...

journal_title：Influenza and other respiratory viruses

authors： Smith LE,D'Antoni D,Jain V,Pearce JM,Weinman J,Rubin GJ

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:The Yangtze river delta in eastern China, centered on Shanghai, is one of the most populated regions of the world with more than 100 million residents. We examined the impact of influenza on excess mortality in Yancheng, a prefecture-level city with 8.2 million population located 250 km north of Shanghai, ...

journal_title：Influenza and other respiratory viruses

authors： Zhang H,Xiong Q,Wu P,Chen Y,Leung NHL,Cowling BJ

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:We aimed to examine the efficacy of medical masks and respirators in protecting against respiratory infections using pooled data from two homogenous randomised control clinical trials (RCTs). METHODS:The data collected on 3591 subjects in two similar RCTs conducted in Beijing, China, which examined the same ...

journal_title：Influenza and other respiratory viruses

authors： MacIntyre CR,Chughtai AA,Rahman B,Peng Y,Zhang Y,Seale H,Wang X,Wang Q

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Given their medical vulnerabilities, we investigated the epidemiological factors related to H1N1 infection in school-aged children. METHODS:This study analyzed data collected on 7448 school-aged children in South Korea between 18 November and 8 December 2009. RESULTS:We found that H1N1 infection was associa...

journal_title：Influenza and other respiratory viruses

authors： Kim CO,Nam CM,Lee DC,Chang J,Lee JW

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Knowledge of the secondary attack rate (SAR) and serial interval (SI) of influenza is important for assessing the severity of seasonal epidemics of the virus. To date, such estimates have required extensive surveys of target populations. Here, we propose a method for estimating the intrafamily SAR and SI fro...

journal_title：Influenza and other respiratory viruses

authors： Yom-Tov E,Johansson-Cox I,Lampos V,Hayward AC

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The relationship between obesity and susceptibility to influenza infection in humans is unclear. Morbidly obese people were at an increased risk of complications from 2009 pandemic H1N1 influenza [A(H1N1)pdm09]. OBJECTIVE:The goal of this study was to determine whether medically attended, laboratory-confirm...

journal_title：Influenza and other respiratory viruses

authors： Coleman LA,Waring SC,Irving SA,Vandermause M,Shay DK,Belongia EA

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Several studies have demonstrated the role of meteorological parameters in the seasonality of influenza viruses in tropical and subtropical regions, most importantly temperature, humidity, and rainfall. OBJECTIVES:This study aimed to describe the influence of meteorological parameters in the seasonality of ...

journal_title：Influenza and other respiratory viruses

authors： Munshili Njifon HL,Monamele CG,Kengne Nde C,Vernet MA,Bouba G,Tchatchouang S,Njankouo MR,Tapondjou R,Deweerdt L,Mbacham W,Njouom R

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Minimal influenza surveillance has been carried out in sub-Saharan Africa to provide information on circulating influenza subtypes for the purpose of vaccine production and monitoring trends in virus spread and mutations. OBJECTIVE:The aim of this study was to investigate a surveillance program in Kenya to ...

journal_title：Influenza and other respiratory viruses

authors： Bulimo WD,Garner JL,Schnabel DC,Bedno SA,Njenga MK,Ochieng WO,Amukoye E,Magana JM,Simwa JM,Ofula VO,Lifumo SM,Wangui J,Breiman RF,Martin SK

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:The goal of this double-blind, randomized, controlled clinical trial was to assess the safety and immunogenicity of two different doses of a monovalent split-virion 2009 pandemic influenza A/H1N1 vaccine without adjuvant in Chinese infants aged 6-35 months. DESIGN AND SETTING  Subjects were randomly assigned...

journal_title：Influenza and other respiratory viruses

authors： Li YP,Li W,Liang XF,Liu Y,Huang XC,Li CG,Li RC,Wang JZ,Wang HQ,Yin WD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:During April-July 2009, U.S. hospitalization rates for 2009 pandemic influenza A (H1N1) virus (H1N1pdm09) infection were estimated at 4·5/100 000 persons. We describe rates and risk factors for H1N1pdm09 infection among American Indians (AIs) in four isolated southwestern U.S. communities served by the India...

journal_title：Influenza and other respiratory viruses

authors： Suryaprasad A,Redd JT,Hancock K,Branch A,Steward-Clark E,Katz JM,Fry AM,Cheek JE,Influenza Serology Working Group.,American Indian and Alaska Native Pandemic Influenza A (H1N1) Investigation Team.

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Reviews of the global response to the 2009 pandemic of influenza A/H1N1 affirmed the importance of assessment of preparedness and response capabilities. DESIGN:The U. S. Centers for Disease Control and Prevention (CDC) and partners developed the National Inventory of Core Capabilities for Pandemic Influenza...

journal_title：Influenza and other respiratory viruses

authors： MacDonald G,Moen AC,St Louis ME

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Literature on influenza focuses on influenza A, despite influenza B having a large public health impact. The Global Influenza B Study aims to collect information on global epidemiology and burden of disease of influenza B since 2000. METHODS:Twenty-six countries in the Southern (n = 5) and Northern (n = 7...

journal_title：Influenza and other respiratory viruses

authors： Caini S,Huang QS,Ciblak MA,Kusznierz G,Owen R,Wangchuk S,Henriques CM,Njouom R,Fasce RA,Yu H,Feng L,Zambon M,Clara AW,Kosasih H,Puzelli S,Kadjo HA,Emukule G,Heraud JM,Ang LW,Venter M,Mironenko A,Brammer L,Mai

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The 2009 pandemic H1N1 (A(H1N1)pdm09) influenza A virus (IAV) has replaced the previous seasonal H1N1 strain in humans and continues to circulate worldwide. The comparative performance of inactivated A(H1N1)pdm09 influenza vaccines remains of considerable interest. The objective of this study was to evaluate...

journal_title：Influenza and other respiratory viruses

authors： Vidaña B,Brookes SM,Everett HE,Garcon F,Nuñez A,Engelhardt O,Major D,Hoschler K,Brown IH,Zambon M

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Recent outbreaks of highly pathogenic avian influenza and multiple occurrences of zoonotic infection and deaths in humans have sparked a dramatic increase in influenza research. In order to rapidly identify and help prevent future influenza outbreaks, numerous laboratories around the world are working to dev...

journal_title：Influenza and other respiratory viruses

authors： Bose ME,Littrell JC,Patzer AD,Kraft AJ,Metallo JA,Fan J,Henrickson KJ

更新日期：2008-01-01 00:00:00

abstract：:Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA have been detected in some individuals following treatment. Here, we d...

journal_title：Influenza and other respiratory viruses

authors： Koszalka P,Farrukee R,Mifsud E,Vijaykrishna D,Hurt AC

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:To estimate, using Bayesian evidence synthesis, the age-group-specific annual incidence of symptomatic infection with seasonal influenza in the Netherlands over the period 2005-2007. METHODS:The Netherlands population and age group distribution for 2006 defined the base population. The number of influenza-l...

journal_title：Influenza and other respiratory viruses

authors： McDonald SA,Presanis AM,De Angelis D,van der Hoek W,Hooiveld M,Donker G,Kretzschmar ME

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Fever and respiratory symptoms are the major causes of hospitalisation in infants aged 90 days or less. Respiratory viruses (RVs) are detected by multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) in up to 70% of infants tested in this population. Aminotransferase elevation is not uncommon i...

journal_title：Influenza and other respiratory viruses

authors： Kim SG,Oh YN,Lee JK

更新日期：2020-07-01 00:00:00