Abstract:
:Oseltamivir-resistant 2009 H1N1 influenza virus infections associated with neuraminidase (NA) H275Y have been identified sporadically. Strains possessing the hemagglutinin (HA) D222G mutation have been detected in small numbers of fatal 2009 H1N1 cases. We report the first clinical description of 2009 H1N1 virus infection with both NA-H275Y and HA-D222G mutations detected by pyrosequencing of bronchioalveolar lavage fluid obtained on symptom day 19. The 59-year-old immunosuppressed patient had multiple conditions conferring higher risk of prolonged viral replication and severe illness and died on symptom day 34. Further investigations are needed to determine the significance of infection with strains possessing NA-H275Y and HA-D222G.
journal_name
Influenza Other Respir Virusesjournal_title
Influenza and other respiratory virusesauthors
DeVries A,Wotton J,Lees C,Boxrud D,Uyeki T,Lynfield Rdoi
10.1111/j.1750-2659.2011.00329.xsubject
Has Abstractpub_date
2012-11-01 00:00:00pages
e85-8issue
6eissn
1750-2640issn
1750-2659journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Nineteen mass vaccination clinics were established in Montreal, Canada, as part of the 2009 influenza A/H1N1p vaccination campaign. Although approximately 50% of the population was vaccinated, there was a considerable variation in clinic performance and community vaccine coverage. OBJECTIVE:To identify comm...
journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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doi:10.1111/j.1750-2659.2011.00242.x
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journal_title:Influenza and other respiratory viruses
pub_type: 历史文章,杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2007.00031.x
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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更新日期:2015-03-01 00:00:00
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journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2008.00052.x
更新日期:2008-09-01 00:00:00
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journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2009.00102.x
更新日期:2009-11-01 00:00:00
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journal_title:Influenza and other respiratory viruses
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更新日期:2020-07-01 00:00:00
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doi:10.1111/irv.12757
更新日期:2020-09-01 00:00:00
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journal_title:Influenza and other respiratory viruses
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更新日期:2017-05-01 00:00:00
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doi:10.1111/irv.12545
更新日期:2018-05-01 00:00:00
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更新日期:2014-01-01 00:00:00
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更新日期:2019-09-01 00:00:00
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更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-11-01 00:00:00
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更新日期:2013-12-01 00:00:00
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journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2011.00246.x
更新日期:2011-11-01 00:00:00