Abstract:
:Progress in the development of antivirals for non-influenza respiratory viruses has been slow with the result that many unmet medical needs and few approved agents currently exist. This commentary selectively reviews examples of where specific agents have provided promising clinical benefits in selected target populations and also considers potential therapeutics for emerging threats like the SARS and Middle East respiratory syndrome coronaviruses. Recent studies have provided encouraging results in treating respiratory syncytial virus infections in lung transplant recipients, serious parainfluenza virus and adenovirus infections in immunocompromised hosts, and rhinovirus colds in outpatient asthmatics. While additional studies are needed to confirm the efficacy and safety of the specific agents tested, these observations offer the opportunity to expand therapeutic studies to other patient populations.
journal_name
Influenza Other Respir Virusesjournal_title
Influenza and other respiratory virusesauthors
Hayden FGdoi
10.1111/irv.12173subject
Has Abstractpub_date
2013-11-01 00:00:00pages
36-43eissn
1750-2640issn
1750-2659journal_volume
7 Suppl 3pub_type
杂志文章,评审abstract::This study used Poisson regression modelling to estimate influenza-associated mortality in New Zealand for 1990-2008. Inputs were weekly numbers of deaths and influenza and RSV isolates. Seasonal influenza was associated with an average of 401 medical deaths annually from 1990 to 2008, a rate of 10.6 (95% CI: 7.9, 13....
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12292
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Respiratory syncytial virus (RSV) is an important cause of medically attended acute respiratory illnesses in older adults but awareness of the relevance of RSV in older people remains lower than that of influenza, which exhibits similar clinical characteristics to those of RSV. OBJECTIVES:This study was per...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12754
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Guillain-Barre syndrome (GBS) is a rare autoimmune disease characterized by acute, progressive peripheral neuropathy and is commonly associated with the presence of antiganglioside antibodies. Previously, influenza vaccination was linked with the increased incidence of GBS; however, whether antiganglioside a...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2011.00294.x
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Influenza and other respiratory infections cause excess winter morbidity in children. This study assessed the economic impact of influenza-like illness (ILI) on families with children attending childcare using a societal perspective. METHODS:We conducted a prospective cohort study in 90 childcare centres an...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12138
更新日期:2013-11-01 00:00:00
abstract::We conducted two surveys to evaluate the health-seeking behaviors of individuals with acute respiratory infections (ARI) during the COVID-19 outbreak in Wuhan, China. Among 351 participants reporting ARI (10.3%, 351/3,411), 36.5% sought medical assistance. Children were more likely to seek medical assistance than othe...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12804
更新日期:2020-09-10 00:00:00
abstract:CONTEXT:Preventing nosocomial transmission of influenza is essential to reduce the morbidity and mortality associated with this infection. In October 2009, an outbreak of the 2009 influenza A (H1N1) virus occurred in a hematology ward of a children's hospital over a 21-day period and involved two patients and four heal...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2011.00322.x
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Reviews of the global response to the 2009 pandemic of influenza A/H1N1 affirmed the importance of assessment of preparedness and response capabilities. DESIGN:The U. S. Centers for Disease Control and Prevention (CDC) and partners developed the National Inventory of Core Capabilities for Pandemic Influenza...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12218
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:A single case of novel influenza A (H1N1) 09 infection was identified by PCR among a New Zealand high-school group that toured California in April 2009. Close monitoring of the tour group and their New Zealand contacts identified 11 other tour members with respiratory symptoms who were investigated. In all n...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2010.00169.x
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Influenza and respiratory syncytial viruses (RSV) are important viral pathogens in childhood. OBJECTIVES:Our aim was to estimate the effect of influenza and RSV on excess hospitalizations for acute lower respiratory tract infections (ALRTI) in children aged≤5. METHODS:Retrospective, population-based study ...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12134
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Antibodies to neuraminidase (NA) contribute to protection during influenza virus infection, but NA inhibition (NI) titers are not routinely analyzed in vaccine trials. One reason is the cumbersome nature of the conventional thiobarbituric acid (TBA) NI assay, which uses chemical methods to quantify free sial...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2009.00094.x
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Hospitalization burden associated with influenza and respiratory syncytial virus (RSV) is uncertain due to ambiguity in the inference methodologies employed for its estimation. OBJECTIVES:Utilization of a new method to quantitate the above burden. METHODS:Weekly hospitalization rates for several principal ...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12325
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Nineteen mass vaccination clinics were established in Montreal, Canada, as part of the 2009 influenza A/H1N1p vaccination campaign. Although approximately 50% of the population was vaccinated, there was a considerable variation in clinic performance and community vaccine coverage. OBJECTIVE:To identify comm...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12227
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Modern molecular techniques reveal new information on the role of respiratory viruses in community-acquired pneumonia. In this study, we tried to determine the prevalence of respiratory viruses and bacteria in patients with community-acquired pneumonia who were admitted to the hospital. METHODS:Between Apri...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2012.00425.x
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Minimal influenza surveillance has been carried out in sub-Saharan Africa to provide information on circulating influenza subtypes for the purpose of vaccine production and monitoring trends in virus spread and mutations. OBJECTIVE:The aim of this study was to investigate a surveillance program in Kenya to ...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2008.00044.x
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:The Northern Territory (NT) of Australia has a mix of climates, sparsely distributed population and a large proportion of the populace are Indigenous Australians, and influenza is known to have a disproportionate impact upon this group. Understanding the epidemiology of influenza in this region would inform ...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12757
更新日期:2020-09-01 00:00:00
abstract:AIM:To determine factors associated with severe hospitalized Respiratory syncytial virus (RSV)-associated LRTI and to describe management in tertiary care center. METHODS:Retrospective medical record review was conducted among children under 5 years old hospitalized with RSV-associated LRTI at King Chulalongkorn Memor...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12793
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Influenza surveillance helps time prevention and control interventions especially where complex seasonal patterns exist. We assessed influenza surveillance sustainability in Africa where influenza activity varies and external funds for surveillance have decreased. METHODS:We surveyed African Network for Inf...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12818
更新日期:2020-11-04 00:00:00
abstract::An outbreak of highly pathogenic avian influenza A (H5N6) virus occurred between November 20, 2016, and March 1, 2017 in poultry farms, in the Gyeonggi Province, Republic of Korea. To identify the risk of transmission of H5N6 to depopulation workers, active and passive surveillance was conducted. Virological testing o...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12530
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:The Yangtze river delta in eastern China, centered on Shanghai, is one of the most populated regions of the world with more than 100 million residents. We examined the impact of influenza on excess mortality in Yancheng, a prefecture-level city with 8.2 million population located 250 km north of Shanghai, ...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12487
更新日期:2018-01-01 00:00:00
abstract::Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA have been detected in some individuals following treatment. Here, we d...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12725
更新日期:2020-07-01 00:00:00
abstract:BACKGROUNDS:Influenza can spread rapidly in long-term care facilities (LTCFs), and residents are usually at higher risk for influenza infections. OBJECTIVE:Our study aimed to evaluate the effectiveness of antiviral interventions on outbreak control. METHODS:Taiwan Centers for Disease Control used a syndromic surveill...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12536
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Recent outbreaks of highly pathogenic avian influenza and multiple occurrences of zoonotic infection and deaths in humans have sparked a dramatic increase in influenza research. In order to rapidly identify and help prevent future influenza outbreaks, numerous laboratories around the world are working to dev...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2007.00031.x
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:It has been suggested that live attenuated influenza vaccine (LAIV) may be less effective in older individuals because of prior wild-type influenza infections. LAIV is currently approved in the United States, South Korea and Hong Kong for individuals 2-49 years of age. OBJECTIVE:To examine data from previou...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章,meta分析
doi:10.1111/j.1750-2659.2009.00124.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:Knowledge of the secondary attack rate (SAR) and serial interval (SI) of influenza is important for assessing the severity of seasonal epidemics of the virus. To date, such estimates have required extensive surveys of target populations. Here, we propose a method for estimating the intrafamily SAR and SI fro...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12321
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Given their medical vulnerabilities, we investigated the epidemiological factors related to H1N1 infection in school-aged children. METHODS:This study analyzed data collected on 7448 school-aged children in South Korea between 18 November and 8 December 2009. RESULTS:We found that H1N1 infection was associa...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2011.00318.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:To preliminary preview the molecular character and its possible clinical correlation of RSV subgroups in Thailand. DESIGN:Cross-sectional analytic design. SETTING:Admitted acute lower respiratory tract infection patients of King Chulalongkorn Memorial Hospital, Bangkok, during Jun-Dec, 2007 were recruited....
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2010.00152.x
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Respiratory protective devices are critical in protecting against infection in healthcare workers at high risk of novel 2019 coronavirus disease (COVID-19); however, recommendations are conflicting and epidemiological data on their relative effectiveness against COVID-19 are limited. PURPOSE:To compare medi...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章,meta分析
doi:10.1111/irv.12745
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In this study we investigated the levels of cytokines and chemokines produced locally and systemically after influenza vaccination of patients undergoing tonsillectomy. METHODS:Blood and saliva were collected prior to, and 1 or 2 weeks after vaccination at the time of the tonsillectomy. The cy...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2007.00019.x
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:The new influenza virus A/H1N1 (2009), identified in mid-2009, rapidly spread over the world. Estimating the transmissibility of this new virus was a public health priority. METHODS:We reviewed all studies presenting estimates of the serial interval or generation time and the reproduction number of the A/H1...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章,评审
doi:10.1111/j.1750-2659.2011.00234.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:Influenza-associated myositis (IAM), characterized by severe lower-extremity myalgia and reluctance to walk, is a complication of influenza among children. We investigated IAM in Nebraska during six influenza seasons, 2001-2007. METHODS:During 2006-2007, we requested reports of severe influenza illness among...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2009.00102.x
更新日期:2009-11-01 00:00:00