Risk factors of severe hospitalized respiratory syncytial virus infection in tertiary care center in Thailand.

Abstract:

AIM:To determine factors associated with severe hospitalized Respiratory syncytial virus (RSV)-associated LRTI and to describe management in tertiary care center. METHODS:Retrospective medical record review was conducted among children under 5 years old hospitalized with RSV-associated LRTI at King Chulalongkorn Memorial Hospital. Severe RSV-associated LRTI was defined as death, mechanical ventilator, or positive pressure ventilation use, prolonged hospitalization >7 days. Factors associated with severe RSV were analyzed using univariate and multivariate logistic regression. RESULTS:From January 2011 to December 2016, 427 children were hospitalized. Median age was 10 months (IQR 4.2-23.0). One hundred seventy-four (41%) patients had severe RSV (11 deaths, 56 mechanical ventilators, 19 positive pressure ventilation, and 88 prolonged hospitalization). Factors associated with severe RSV were chronic lung disease (aOR 15.16 [4.26-53.91]), cirrhosis/biliary atresia (aOR 15.01 [3.21-70.32]), congenital heart disease (aOR 5.11 [1.97-13.23]), chemotherapy (aOR 4.7 [1.34-16.56]), and pre-term (aOR 2.03 [1.13-3.67]). Oxygen therapy was mainly low flow oxygen delivery. 88% of cases received bronchodilator. Parenteral antibiotics were prescribed in 37.9% of cases. CONCLUSIONS:Children with co-morbidities have higher risk of severe RSV-associated LRTI. More than two-third of patients received bronchodilator, of which was not recommended by American Academy of Pediatrics. The specific treatment and prevention for RSV are urgently needed.

authors

Aikphaibul P,Theerawit T,Sophonphan J,Wacharachaisurapol N,Jitrungruengnij N,Puthanakit T

doi

10.1111/irv.12793

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

64-71

issue

1

eissn

1750-2640

issn

1750-2659

journal_volume

15

pub_type

杂志文章
  • Influenza vaccination coverage and effectiveness in young children in Thailand, 2011-2013.

    abstract:BACKGROUND:Since 2009, Thailand has recommended influenza vaccine for children aged 6 months through 2 years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group. METHODS:During August 2011-May 2013, high-risk and healthy children aged ≤36 months were enrolled in a 2-yea...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12302

    authors: Kittikraisak W,Suntarattiwong P,Levy J,Fernandez S,Dawood FS,Olsen SJ,Chotpitayasunondh T

    更新日期:2015-03-01 00:00:00

  • Influenza hospitalization epidemiology from a severe acute respiratory infection surveillance system in Jordan, January 2008-February 2014.

    abstract:BACKGROUND:Acute respiratory infections (ARIs) are a major cause of morbidity and mortality worldwide. Influenza typically contributes substantially to the burden of ARI, but only limited data are available on influenza activity and seasonality in Jordan. METHODS:Syndromic case definitions were used to identify indivi...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12354

    authors: Al-Abdallat M,Dawson P,Haddadin AJ,El-Shoubary W,Dueger E,Al-Sanouri T,Said MM,Talaat M

    更新日期:2016-03-01 00:00:00

  • Health-seeking behaviors of patients with acute respiratory infections during the outbreak of novel coronavirus disease 2019 in Wuhan, China.

    abstract::We conducted two surveys to evaluate the health-seeking behaviors of individuals with acute respiratory infections (ARI) during the COVID-19 outbreak in Wuhan, China. Among 351 participants reporting ARI (10.3%, 351/3,411), 36.5% sought medical assistance. Children were more likely to seek medical assistance than othe...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12804

    authors: Yang J,Gong H,Chen X,Chen Z,Deng X,Qian M,Hou Z,Ajelli M,Viboud C,Yu H

    更新日期:2020-09-10 00:00:00

  • Transmission parameters of the A/H1N1 (2009) influenza virus pandemic: a review.

    abstract:BACKGROUND:The new influenza virus A/H1N1 (2009), identified in mid-2009, rapidly spread over the world. Estimating the transmissibility of this new virus was a public health priority. METHODS:We reviewed all studies presenting estimates of the serial interval or generation time and the reproduction number of the A/H1...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,评审

    doi:10.1111/j.1750-2659.2011.00234.x

    authors: Boëlle PY,Ansart S,Cori A,Valleron AJ

    更新日期:2011-09-01 00:00:00

  • Rapid detection and subtyping of European swine influenza viruses in porcine clinical samples by haemagglutinin- and neuraminidase-specific tetra- and triplex real-time RT-PCRs.

    abstract:BACKGROUND:A diversifying pool of mammalian-adapted influenza A viruses (IAV) with largely unknown zoonotic potential is maintained in domestic swine populations worldwide. The most recent human influenza pandemic in 2009 was caused by a virus with genes originating from IAV isolated from swine. Swine influenza viruses...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12407

    authors: Henritzi D,Zhao N,Starick E,Simon G,Krog JS,Larsen LE,Reid SM,Brown IH,Chiapponi C,Foni E,Wacheck S,Schmid P,Beer M,Hoffmann B,Harder TC

    更新日期:2016-11-01 00:00:00

  • The Influenza Primer Design Resource: a new tool for translating influenza sequence data into effective diagnostics.

    abstract:BACKGROUND:Recent outbreaks of highly pathogenic avian influenza and multiple occurrences of zoonotic infection and deaths in humans have sparked a dramatic increase in influenza research. In order to rapidly identify and help prevent future influenza outbreaks, numerous laboratories around the world are working to dev...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2007.00031.x

    authors: Bose ME,Littrell JC,Patzer AD,Kraft AJ,Metallo JA,Fan J,Henrickson KJ

    更新日期:2008-01-01 00:00:00

  • Low-dose oral interferon alpha as prophylaxis against viral respiratory illness: a double-blind, parallel controlled trial during an influenza pandemic year.

    abstract:BACKGROUND AND OBJECTIVE:Interferon alpha (IFNα) is a known antiviral agent. A double-blind, placebo-controlled clinical trial was conducted investigating the use of low-dose oral interferon alpha for preventing acute viral respiratory illnesses. METHODS:Two hundred healthy adults aged 18-75 years were enrolled and co...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/irv.12094

    authors: Bennett AL,Smith DW,Cummins MJ,Jacoby PA,Cummins JM,Beilharz MW

    更新日期:2013-09-01 00:00:00

  • Severity and mortality of respiratory syncytial virus vs influenza A infection in hospitalized adults in China.

    abstract:BACKGROUND:Respiratory syncytial virus (RSV) is an important cause of medically attended acute respiratory illnesses in older adults but awareness of the relevance of RSV in older people remains lower than that of influenza, which exhibits similar clinical characteristics to those of RSV. OBJECTIVES:This study was per...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12754

    authors: Zhang Y,Wang Y,Zhao J,Xiong Z,Fan Y,Zhang W,Zou X,Wang C,Han J,Li B,Lu B,Cao B,CAP-China Network.

    更新日期:2020-09-01 00:00:00

  • The efficacy of medical masks and respirators against respiratory infection in healthcare workers.

    abstract:OBJECTIVE:We aimed to examine the efficacy of medical masks and respirators in protecting against respiratory infections using pooled data from two homogenous randomised control clinical trials (RCTs). METHODS:The data collected on 3591 subjects in two similar RCTs conducted in Beijing, China, which examined the same ...

    journal_title:Influenza and other respiratory viruses

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/irv.12474

    authors: MacIntyre CR,Chughtai AA,Rahman B,Peng Y,Zhang Y,Seale H,Wang X,Wang Q

    更新日期:2017-11-01 00:00:00

  • Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis.

    abstract:BACKGROUND:Pregnant women have an elevated risk of illness and hospitalisation from influenza. Pregnant women are recommended to be prioritised for influenza vaccination during any stage of pregnancy. The risk of seasonal influenza varies substantially throughout the year in temperate climates; however, there is limite...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,meta分析

    doi:10.1111/irv.12649

    authors: Cuningham W,Geard N,Fielding JE,Braat S,Madhi SA,Nunes MC,Christian LM,Lin SY,Lee CN,Yamaguchi K,Bisgaard H,Chawes B,Chao AS,Blanchard-Rohner G,Schlaudecker EP,Fisher BM,McVernon J,Moss R

    更新日期:2019-09-01 00:00:00

  • Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico.

    abstract:BACKGROUND:Respiratory syncytial virus (RSV) is a leading etiological agent of acute respiratory tract infections and hospitalizations in children. However, little information is available regarding RSV infections in Latin American countries, particularly among adult patients. OBJECTIVE:To describe the epidemiology of...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12414

    authors: Gamiño-Arroyo AE,Moreno-Espinosa S,Llamosas-Gallardo B,Ortiz-Hernández AA,Guerrero ML,Galindo-Fraga A,Galán-Herrera JF,Prado-Galbarro FJ,Beigel JH,Ruiz-Palacios GM,Noyola DE,Mexico Emerging Infectious Diseases Clinical Research Net

    更新日期:2017-01-01 00:00:00

  • Factors associated with influenza vaccination among healthcare workers in acute care hospitals in Canada.

    abstract:BACKGROUND:Influenza vaccine coverage rates among healthcare workers (HCWs) in acute care facilities in Canada remain below national targets. OBJECTIVE:To determine factors associated with influenza vaccine uptake among HCWs. METHODS:This secondary analysis of a prospective cohort study included HCWs aged 18-69 years...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12545

    authors: Hussain H,McGeer A,McNeil S,Katz K,Loeb M,Simor A,Powis J,Langley J,Muller M,Canadian Health Care Worker Study Group.,Coleman BL

    更新日期:2018-05-01 00:00:00

  • Immunogenicity and safety of a 2009 pandemic influenza A (H1N1) monovalent vaccine in Chinese infants aged 6-35 months: a randomized, double-blind, controlled phase I clinical trial.

    abstract:OBJECTIVES:The goal of this double-blind, randomized, controlled clinical trial was to assess the safety and immunogenicity of two different doses of a monovalent split-virion 2009 pandemic influenza A/H1N1 vaccine without adjuvant in Chinese infants aged 6-35 months. DESIGN AND SETTING  Subjects were randomly assigned...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/irv.12028

    authors: Li YP,Li W,Liang XF,Liu Y,Huang XC,Li CG,Li RC,Wang JZ,Wang HQ,Yin WD

    更新日期:2013-11-01 00:00:00

  • Long-term vaccine-induced heterologous protection against H5N1 influenza viruses in the ferret model.

    abstract:BACKGROUND:Highly pathogenic H5N1 influenza viruses reemerged in humans in 2003 and have caused fatal human infections in Asia and Africa as well as ongoing outbreaks in poultry. These viruses have evolved substantially and are now so antigenically varied that a single vaccine antigen may not protect against all circul...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2012.00423.x

    authors: Ducatez MF,Webb A,Crumpton JC,Webby RJ

    更新日期:2013-07-01 00:00:00

  • Estimating influenza-associated mortality in New Zealand from 1990 to 2008.

    abstract::This study used Poisson regression modelling to estimate influenza-associated mortality in New Zealand for 1990-2008. Inputs were weekly numbers of deaths and influenza and RSV isolates. Seasonal influenza was associated with an average of 401 medical deaths annually from 1990 to 2008, a rate of 10.6 (95% CI: 7.9, 13....

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12292

    authors: Kessaram T,Stanley J,Baker MG

    更新日期:2015-01-01 00:00:00

  • A comparative antibody study of the potential susceptibility of Thoroughbred and non-Thoroughbred horse populations in Ireland to equine influenza virus.

    abstract:BACKGROUND:In Ireland, horses may be protected against equine influenza virus (EIV) as a result of natural exposure or vaccination. Current mandatory vaccination programmes are targeted at highly mobile horses. A correlation between antibody levels as measured by single radial haemolysis (SRH) and protective immunity a...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2010.00163.x

    authors: Gildea S,Arkins S,Cullinane A

    更新日期:2010-11-01 00:00:00

  • Brief literature review for the WHO global influenza research agenda--highly pathogenic avian influenza H5N1 risk in humans.

    abstract::Highly pathogenic avian influenza A H5N1 viruses remain a significant health threat to humans given the continued rare occurrence of human cases with a high case fatality rate. This brief literature review summarizes available evidence of risk factors for H5N1 infection in humans and updates a recent systematic review...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,评审

    doi:10.1111/irv.12077

    authors: Van Kerkhove MD

    更新日期:2013-09-01 00:00:00

  • Epidemiological and virological characteristics of influenza B: results of the Global Influenza B Study.

    abstract:INTRODUCTION:Literature on influenza focuses on influenza A, despite influenza B having a large public health impact. The Global Influenza B Study aims to collect information on global epidemiology and burden of disease of influenza B since 2000. METHODS:Twenty-six countries in the Southern (n = 5) and Northern (n = 7...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12319

    authors: Caini S,Huang QS,Ciblak MA,Kusznierz G,Owen R,Wangchuk S,Henriques CM,Njouom R,Fasce RA,Yu H,Feng L,Zambon M,Clara AW,Kosasih H,Puzelli S,Kadjo HA,Emukule G,Heraud JM,Ang LW,Venter M,Mironenko A,Brammer L,Mai

    更新日期:2015-08-01 00:00:00

  • Combination of procalcitonin and C-reactive protein levels in the early diagnosis of bacterial co-infections in children with H1N1 influenza.

    abstract:OBJECTIVE:This study evaluated the diagnostic value of measuring the levels of procalcitonin (PCT) and C-reactive protein (CRP) to differentiate children co-infected with H1N1 influenza and bacteria from children infected with H1N1 influenza alone. METHODS:Consecutive patients (children aged < 5 years) with laboratory...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12621

    authors: Li Z,He L,Li S,He W,Zha C,Ou W,Hou Q,Wang W,Sun X,Liang H

    更新日期:2019-03-01 00:00:00

  • Efficacy of live attenuated influenza vaccine in children 6 months to 17 years of age.

    abstract:BACKGROUND:It has been suggested that live attenuated influenza vaccine (LAIV) may be less effective in older individuals because of prior wild-type influenza infections. LAIV is currently approved in the United States, South Korea and Hong Kong for individuals 2-49 years of age. OBJECTIVE:To examine data from previou...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1750-2659.2009.00124.x

    authors: Belshe RB,Toback SL,Yi T,Ambrose CS

    更新日期:2010-05-01 00:00:00

  • Supply of neuraminidase inhibitors related to reduced influenza A (H1N1) mortality during the 2009-2010 H1N1 pandemic: summary of an ecological study.

    abstract::When the influenza A (H1N1) pandemic spread across the globe from April 2009 to August 2010, many WHO Member States used antiviral drugs, specifically neuraminidase inhibitors (NAIs) oseltamivir and zanamivir, to treat influenza patients in critical condition. Antivirals have been found to be effective in reducing sev...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,评审

    doi:10.1111/irv.12092

    authors: Miller PE,Rambachan A,Hubbard RJ,Li J,Meyer AE,Stephens P,Mounts AW,Rolfes MA,Penn CR

    更新日期:2013-09-01 00:00:00

  • Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model.

    abstract:BACKGROUND:A candidate pandemic influenza H5N1 vaccine should provide rapid and long-lasting immunity against antigenically drifted viruses. As H5N1 viruses are poorly immunogenic, this may require a combination of immune potentiating strategies. An attractive approach is combining the intrinsic immunogenicity of viros...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00256.x

    authors: Pedersen G,Major D,Roseby S,Wood J,Madhun AS,Cox RJ

    更新日期:2011-11-01 00:00:00

  • The impact of influenza and respiratory syncytial virus on hospitalizations for lower respiratory tract infections in young children: Slovenia, 2006-2011.

    abstract:BACKGROUND:Influenza and respiratory syncytial viruses (RSV) are important viral pathogens in childhood. OBJECTIVES:Our aim was to estimate the effect of influenza and RSV on excess hospitalizations for acute lower respiratory tract infections (ALRTI) in children aged≤5. METHODS:Retrospective, population-based study ...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12134

    authors: Učakar V,Sočan M,Trilar KP

    更新日期:2013-11-01 00:00:00

  • Antigenic drift of H1N1 influenza A virus in pigs with and without passive immunity.

    abstract:BACKGROUND:The genetic and antigenic characteristics of influenza A viruses (IAV) within and between species change over time due to antigenic shift and drift. Although pigs are known to play a key role in the epidemiology of IAV between species, little is known about the molecular evolution of IAV hemagglutinin (HA) i...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12190

    authors: Diaz A,Allerson M,Culhane M,Sreevatsan S,Torremorell M

    更新日期:2013-12-01 00:00:00

  • Antivirals in seasonal and pandemic influenza--future perspectives.

    abstract::Antiviral drugs continue to be an important option for the treatment of influenza disease and will likely be the only option during the early phases of pandemic. However, the limited number of drug classes licensed for treatment of influenza raises several issues, particularly in the face of drug resistance. Two class...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12049

    authors: Wathen MW,Barro M,Bright RA

    更新日期:2013-01-01 00:00:00

  • Genetic analysis of H3N2 influenza A viruses isolated in 2006-2007 in Nairobi, Kenya.

    abstract:BACKGROUND:Minimal influenza surveillance has been carried out in sub-Saharan Africa to provide information on circulating influenza subtypes for the purpose of vaccine production and monitoring trends in virus spread and mutations. OBJECTIVE:The aim of this study was to investigate a surveillance program in Kenya to ...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2008.00044.x

    authors: Bulimo WD,Garner JL,Schnabel DC,Bedno SA,Njenga MK,Ochieng WO,Amukoye E,Magana JM,Simwa JM,Ofula VO,Lifumo SM,Wangui J,Breiman RF,Martin SK

    更新日期:2008-05-01 00:00:00

  • Severe acute respiratory infections caused by 2009 pandemic influenza A (H1N1) among American Indians--southwestern United States, May 1-July 21, 2009.

    abstract:BACKGROUND:During April-July 2009, U.S. hospitalization rates for 2009 pandemic influenza A (H1N1) virus (H1N1pdm09) infection were estimated at 4·5/100 000 persons. We describe rates and risk factors for H1N1pdm09 infection among American Indians (AIs) in four isolated southwestern U.S. communities served by the India...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12123

    authors: Suryaprasad A,Redd JT,Hancock K,Branch A,Steward-Clark E,Katz JM,Fry AM,Cheek JE,Influenza Serology Working Group.,American Indian and Alaska Native Pandemic Influenza A (H1N1) Investigation Team.

    更新日期:2013-11-01 00:00:00

  • Unemployment and widespread influenza in America, 1999-2010.

    abstract:BACKGROUND:Research shows that unemployment reduces access to health care and vaccines and increases financial difficulty, family conflict, and other sources of stress that are known to suppress immune function. In addition, seasonal unemployment rates parallel seasonal influenza activity. Following a theory that argue...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00270.x

    authors: Cornwell B

    更新日期:2012-01-01 00:00:00

  • Mortality attributable to pandemic influenza A (H1N1) 2009 in San Luis Potosí, Mexico.

    abstract:BACKGROUND:Acute respiratory infections are a leading cause of morbidity and mortality worldwide. Starting in 2009, pandemic influenza A(H1N1) 2009 virus has become one of the leading respiratory pathogens worldwide. However, the overall impact of this virus as a cause of mortality has not been clearly defined. OBJECT...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2010.00187.x

    authors: Comas-García A,García-Sepúlveda CA,Méndez-de Lira JJ,Aranda-Romo S,Hernández-Salinas AE,Noyola DE

    更新日期:2011-03-01 00:00:00

  • Advances in antivirals for non-influenza respiratory virus infections.

    abstract::Progress in the development of antivirals for non-influenza respiratory viruses has been slow with the result that many unmet medical needs and few approved agents currently exist. This commentary selectively reviews examples of where specific agents have provided promising clinical benefits in selected target populat...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,评审

    doi:10.1111/irv.12173

    authors: Hayden FG

    更新日期:2013-11-01 00:00:00