Assessment of the benefits of seasonal influenza vaccination: Elements of a framework to interpret estimates of vaccine effectiveness and support robust decision-making and communication.

Abstract:

:Systematic reviews and meta-analyses confirm that influenza vaccination reduces the risk of influenza illness by between about 40% and 60% in seasons when circulating influenza stains are well matched to vaccine strains. Influenza vaccine effectiveness (IVE) estimates, however, are often discordant and a source of confusion for decision makers. IVE assessments are increasingly publicized and are often used by policy makers to make decisions about the value of seasonal influenza vaccination. But there is limited guidance on how IVE should be interpreted or used to inform policy. There are several limitations to the use of IVE for decision-making: (a) IVE studies have methodological issues that often complicate the interpretation of their value; and (b) the full impact of vaccination will almost always be greater than the impact assessed by a point estimate of IVE in specific populations or settings. Understanding the strengths and weaknesses of study methodologies and the fundamental limitations of IVE estimates is important for the accuracy of interpretations and support of policy makers' decisions. Here, we review a comprehensive set of issues that need to be considered when interpreting IVE and determining the full benefits of influenza vaccination. We propose that published IVE values should be assessed using an evaluative framework that includes influenza-specific outcomes, types of VE study design, and confounders, among other factors. Better interpretation of IVE will improve the broader assessment of the value of influenza vaccination and ultimately optimize the public health benefits in seasonal influenza vaccination.

authors

Hollingsworth R,El Guerche-Séblain C,Tsai T,Vasiliev Y,Lee S,Bright H,Barbosa P

doi

10.1111/irv.12786

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

164-174

issue

1

eissn

1750-2640

issn

1750-2659

journal_volume

15

pub_type

杂志文章,评审
  • Characteristics of respiratory viral infections during influenza season in Canadian Hutterite Communities.

    abstract:OBJECTIVES:To determined the pathogen-specific incidence of respiratory virus infection in Hutterite communities occurring over the 2008-2009 influenza season and assess temporal characteristics of respiratory illness related to infection. METHODS:3273 participants community members enrolled in a cluster randomized tr...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/irv.12021

    authors: Kim TH,Russell ML,Fonseca K,Aoki F,Horsman G,Van Caeseele P,Chokani K,Voight M,Babiuk L,Moss L,Webby R,Earn DJ,Singh P,Howse C,Loeb M

    更新日期:2013-11-01 00:00:00

  • An outbreak of the 2009 influenza a (H1N1) virus in a children's hospital.

    abstract:CONTEXT:Preventing nosocomial transmission of influenza is essential to reduce the morbidity and mortality associated with this infection. In October 2009, an outbreak of the 2009 influenza A (H1N1) virus occurred in a hematology ward of a children's hospital over a 21-day period and involved two patients and four heal...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00322.x

    authors: Bearden A,Friedrich TC,Goldberg TL,Byrne B,Spiegel C,Schult P,Safdar N

    更新日期:2012-09-01 00:00:00

  • Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico.

    abstract:BACKGROUND:Respiratory syncytial virus (RSV) is a leading etiological agent of acute respiratory tract infections and hospitalizations in children. However, little information is available regarding RSV infections in Latin American countries, particularly among adult patients. OBJECTIVE:To describe the epidemiology of...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12414

    authors: Gamiño-Arroyo AE,Moreno-Espinosa S,Llamosas-Gallardo B,Ortiz-Hernández AA,Guerrero ML,Galindo-Fraga A,Galán-Herrera JF,Prado-Galbarro FJ,Beigel JH,Ruiz-Palacios GM,Noyola DE,Mexico Emerging Infectious Diseases Clinical Research Net

    更新日期:2017-01-01 00:00:00

  • Immune correlates of protection against influenza: challenges for licensure of seasonal and pandemic influenza vaccines, Miami, FL, USA, March 1-3, 2010.

    abstract::The emergence of a novel swine-origin pandemic influenza virus in 2009, together with the continuing circulation of highly pathogenic avian H5N1 viruses and the urgent global need to produce effective vaccines against such public health threats, has prompted a renewed interest in improving our understanding of the imm...

    journal_title:Influenza and other respiratory viruses

    pub_type:

    doi:10.1111/j.1750-2659.2011.00242.x

    authors: Haaheim LR,Katz JM

    更新日期:2011-07-01 00:00:00

  • Efficacy of live attenuated influenza vaccine in children 6 months to 17 years of age.

    abstract:BACKGROUND:It has been suggested that live attenuated influenza vaccine (LAIV) may be less effective in older individuals because of prior wild-type influenza infections. LAIV is currently approved in the United States, South Korea and Hong Kong for individuals 2-49 years of age. OBJECTIVE:To examine data from previou...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1750-2659.2009.00124.x

    authors: Belshe RB,Toback SL,Yi T,Ambrose CS

    更新日期:2010-05-01 00:00:00

  • 1918 pandemic morbidity: The first wave hits the poor, the second wave hits the rich.

    abstract:BACKGROUND:Whether morbidity from the 1918-19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue, the recent literature has hypothesized that morbidity was "socially neutral." OBJECTIVES:To study the associations between influenz...

    journal_title:Influenza and other respiratory viruses

    pub_type: 历史文章,杂志文章

    doi:10.1111/irv.12541

    authors: Mamelund SE

    更新日期:2018-05-01 00:00:00

  • A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine.

    abstract:BACKGROUND:Highly pathogenic avian influenza A/H5N1 virus remains a potential pandemic threat, and it is essential to continue vaccine development against this subtype. A local mucosal immune response in the upper respiratory tract may stop influenza transmission. It is therefore important to develop effective intranas...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12056

    authors: Svindland SC,Pedersen GK,Pathirana RD,Bredholt G,Nøstbakken JK,Jul-Larsen Å,Guzmán CA,Montomoli E,Lapini G,Piccirella S,Jabbal-Gill I,Hinchcliffe M,Cox RJ

    更新日期:2013-11-01 00:00:00

  • Pediatric influenza-associated myositis - Nebraska, 2001-2007.

    abstract:OBJECTIVE:Influenza-associated myositis (IAM), characterized by severe lower-extremity myalgia and reluctance to walk, is a complication of influenza among children. We investigated IAM in Nebraska during six influenza seasons, 2001-2007. METHODS:During 2006-2007, we requested reports of severe influenza illness among...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2009.00102.x

    authors: Buss BF,Shinde VM,Safranek TJ,Uyeki TM

    更新日期:2009-11-01 00:00:00

  • A systematic review of factors affecting intended and actual adherence with antiviral medication as treatment or prophylaxis in seasonal and pandemic flu.

    abstract::The aim of this review was to identify factors predicting actual or intended adherence to antivirals as treatment or prophylaxis for influenza. Literature from inception to March 2015 was systematically reviewed to find studies reporting predictors of adherence to antivirals and self-reported reasons for non-adherence...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,评审

    doi:10.1111/irv.12406

    authors: Smith LE,D'Antoni D,Jain V,Pearce JM,Weinman J,Rubin GJ

    更新日期:2016-11-01 00:00:00

  • Epidemiological and virological characteristics of influenza B: results of the Global Influenza B Study.

    abstract:INTRODUCTION:Literature on influenza focuses on influenza A, despite influenza B having a large public health impact. The Global Influenza B Study aims to collect information on global epidemiology and burden of disease of influenza B since 2000. METHODS:Twenty-six countries in the Southern (n = 5) and Northern (n = 7...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12319

    authors: Caini S,Huang QS,Ciblak MA,Kusznierz G,Owen R,Wangchuk S,Henriques CM,Njouom R,Fasce RA,Yu H,Feng L,Zambon M,Clara AW,Kosasih H,Puzelli S,Kadjo HA,Emukule G,Heraud JM,Ang LW,Venter M,Mironenko A,Brammer L,Mai

    更新日期:2015-08-01 00:00:00

  • Assessing the impact of public health interventions on the transmission of pandemic H1N1 influenza a virus aboard a Peruvian navy ship.

    abstract:BACKGROUND:Limited data exist on transmission dynamics and effectiveness of control measures for influenza in confined settings. OBJECTIVES:To investigate the transmission dynamics of a 2009 pandemic H1N1 influenza A outbreak aboard a Peruvian Navy ship and quantify the effectiveness of the implemented control measure...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12240

    authors: Vera DM,Hora RA,Murillo A,Wong JF,Torre AJ,Wang D,Boulay D,Hancock K,Katz JM,Ramos M,Loayza L,Quispe J,Reaves EJ,Bausch DG,Chowell G,Montgomery JM

    更新日期:2014-05-01 00:00:00

  • Clinical implications of aminotransferase elevation in hospitalised infants aged 8-90 days with respiratory virus detection.

    abstract:BACKGROUND:Fever and respiratory symptoms are the major causes of hospitalisation in infants aged 90 days or less. Respiratory viruses (RVs) are detected by multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) in up to 70% of infants tested in this population. Aminotransferase elevation is not uncommon i...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12732

    authors: Kim SG,Oh YN,Lee JK

    更新日期:2020-07-01 00:00:00

  • Antivirals in seasonal and pandemic influenza--future perspectives.

    abstract::Antiviral drugs continue to be an important option for the treatment of influenza disease and will likely be the only option during the early phases of pandemic. However, the limited number of drug classes licensed for treatment of influenza raises several issues, particularly in the face of drug resistance. Two class...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12049

    authors: Wathen MW,Barro M,Bright RA

    更新日期:2013-01-01 00:00:00

  • Detection of enterovirus 68 in serum from pediatric patients with pneumonia and their clinical outcomes.

    abstract::Enterovirus 68 (EV68) infection occasionally manifests with fatal outcomes. However, detection of EV68 in serum and its clinical outcomes are yet to be determined. In this study, we retrospectively tested stored serum samples collected from pediatric pneumonia patients whose nasopharyngeal specimens were positive for ...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12206

    authors: Imamura T,Suzuki A,Lupisan S,Kamigaki T,Okamoto M,Roy CN,Olveda R,Oshitani H

    更新日期:2014-01-01 00:00:00

  • Evidence of reassortment of pandemic H1N1 influenza virus in swine in Argentina: are we facing the expansion of potential epicenters of influenza emergence?

    abstract::In this report, we describe the occurrence of two novel swine influenza viruses (SIVs) in pigs in Argentina. These viruses are the result of two independent reassortment events between the H1N1 pandemic influenza virus (H1N1pdm) and human-like SIVs, showing the constant evolution of influenza viruses at the human-swin...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00246.x

    authors: Pereda A,Rimondi A,Cappuccio J,Sanguinetti R,Angel M,Ye J,Sutton T,Dibárbora M,Olivera V,Craig MI,Quiroga M,Machuca M,Ferrero A,Perfumo C,Perez DR

    更新日期:2011-11-01 00:00:00

  • Is abdominal obesity associated with the 2009 influenza A (H1N1) pandemic in Korean school-aged children?

    abstract:OBJECTIVE:Given their medical vulnerabilities, we investigated the epidemiological factors related to H1N1 infection in school-aged children. METHODS:This study analyzed data collected on 7448 school-aged children in South Korea between 18 November and 8 December 2009. RESULTS:We found that H1N1 infection was associa...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00318.x

    authors: Kim CO,Nam CM,Lee DC,Chang J,Lee JW

    更新日期:2012-09-01 00:00:00

  • Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation).

    abstract::A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole-genome sequencing of 77 influenza A(H1N1)pdm0...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12389

    authors: Komissarov A,Fadeev A,Sergeeva M,Petrov S,Sintsova K,Egorova A,Pisareva M,Buzitskaya Z,Musaeva T,Danilenko D,Konovalova N,Petrova P,Stolyarov K,Smorodintseva E,Burtseva E,Krasnoslobodtsev K,Kirillova E,Karpova L,Eropk

    更新日期:2016-07-01 00:00:00

  • Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model.

    abstract:BACKGROUND:A candidate pandemic influenza H5N1 vaccine should provide rapid and long-lasting immunity against antigenically drifted viruses. As H5N1 viruses are poorly immunogenic, this may require a combination of immune potentiating strategies. An attractive approach is combining the intrinsic immunogenicity of viros...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00256.x

    authors: Pedersen G,Major D,Roseby S,Wood J,Madhun AS,Cox RJ

    更新日期:2011-11-01 00:00:00

  • Brief literature review for the WHO global influenza research agenda--highly pathogenic avian influenza H5N1 risk in humans.

    abstract::Highly pathogenic avian influenza A H5N1 viruses remain a significant health threat to humans given the continued rare occurrence of human cases with a high case fatality rate. This brief literature review summarizes available evidence of risk factors for H5N1 infection in humans and updates a recent systematic review...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,评审

    doi:10.1111/irv.12077

    authors: Van Kerkhove MD

    更新日期:2013-09-01 00:00:00

  • Local and systemic cytokine and chemokine responses after parenteral influenza vaccination.

    abstract:BACKGROUND AND OBJECTIVE:In this study we investigated the levels of cytokines and chemokines produced locally and systemically after influenza vaccination of patients undergoing tonsillectomy. METHODS:Blood and saliva were collected prior to, and 1 or 2 weeks after vaccination at the time of the tonsillectomy. The cy...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2007.00019.x

    authors: Eriksson JC,Cox RJ,Szyszko E,Davidsson A,Brokstad KA

    更新日期:2007-07-01 00:00:00

  • Transmission parameters of the A/H1N1 (2009) influenza virus pandemic: a review.

    abstract:BACKGROUND:The new influenza virus A/H1N1 (2009), identified in mid-2009, rapidly spread over the world. Estimating the transmissibility of this new virus was a public health priority. METHODS:We reviewed all studies presenting estimates of the serial interval or generation time and the reproduction number of the A/H1...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,评审

    doi:10.1111/j.1750-2659.2011.00234.x

    authors: Boëlle PY,Ansart S,Cori A,Valleron AJ

    更新日期:2011-09-01 00:00:00

  • Estimating the secondary attack rate and serial interval of influenza-like illnesses using social media.

    abstract:OBJECTIVES:Knowledge of the secondary attack rate (SAR) and serial interval (SI) of influenza is important for assessing the severity of seasonal epidemics of the virus. To date, such estimates have required extensive surveys of target populations. Here, we propose a method for estimating the intrafamily SAR and SI fro...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12321

    authors: Yom-Tov E,Johansson-Cox I,Lampos V,Hayward AC

    更新日期:2015-07-01 00:00:00

  • Rapid detection and subtyping of European swine influenza viruses in porcine clinical samples by haemagglutinin- and neuraminidase-specific tetra- and triplex real-time RT-PCRs.

    abstract:BACKGROUND:A diversifying pool of mammalian-adapted influenza A viruses (IAV) with largely unknown zoonotic potential is maintained in domestic swine populations worldwide. The most recent human influenza pandemic in 2009 was caused by a virus with genes originating from IAV isolated from swine. Swine influenza viruses...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12407

    authors: Henritzi D,Zhao N,Starick E,Simon G,Krog JS,Larsen LE,Reid SM,Brown IH,Chiapponi C,Foni E,Wacheck S,Schmid P,Beer M,Hoffmann B,Harder TC

    更新日期:2016-11-01 00:00:00

  • Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children.

    abstract:BACKGROUND:Molecular testing for viral pathogens has resulted in increasing detection of multiple viruses in respiratory secretions of ill children. The clinical impact of multiple virus infections on clinical presentation and outcome is unclear. OBJECTIVES:To compare clinical characteristics and viral load between ch...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00265.x

    authors: Martin ET,Kuypers J,Wald A,Englund JA

    更新日期:2012-01-01 00:00:00

  • Severe acute respiratory infections caused by 2009 pandemic influenza A (H1N1) among American Indians--southwestern United States, May 1-July 21, 2009.

    abstract:BACKGROUND:During April-July 2009, U.S. hospitalization rates for 2009 pandemic influenza A (H1N1) virus (H1N1pdm09) infection were estimated at 4·5/100 000 persons. We describe rates and risk factors for H1N1pdm09 infection among American Indians (AIs) in four isolated southwestern U.S. communities served by the India...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12123

    authors: Suryaprasad A,Redd JT,Hancock K,Branch A,Steward-Clark E,Katz JM,Fry AM,Cheek JE,Influenza Serology Working Group.,American Indian and Alaska Native Pandemic Influenza A (H1N1) Investigation Team.

    更新日期:2013-11-01 00:00:00

  • Extremely low risk for acquisition of a respiratory viral infection in the emergency room of a large pediatric hospital during the winter season.

    abstract::The aim of this study was to investigate the rate of transmission of respiratory viral infections to children visiting the emergency room of a large pediatric hospital during winter. A total of 615 children were prospectively studied. Twenty-two (3·6%) children developed at least one symptom compatible with a respirat...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2012.00355.x

    authors: Maltezou HC,Mougkou K,Asimaki H,Koniaraki K,Katerelos P,Giannaki M,Theodoridou M

    更新日期:2013-01-01 00:00:00

  • A comparative antibody study of the potential susceptibility of Thoroughbred and non-Thoroughbred horse populations in Ireland to equine influenza virus.

    abstract:BACKGROUND:In Ireland, horses may be protected against equine influenza virus (EIV) as a result of natural exposure or vaccination. Current mandatory vaccination programmes are targeted at highly mobile horses. A correlation between antibody levels as measured by single radial haemolysis (SRH) and protective immunity a...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2010.00163.x

    authors: Gildea S,Arkins S,Cullinane A

    更新日期:2010-11-01 00:00:00

  • Clinic accessibility and clinic-level predictors of the geographic variation in 2009 pandemic influenza vaccine coverage in Montreal, Canada.

    abstract:BACKGROUND:Nineteen mass vaccination clinics were established in Montreal, Canada, as part of the 2009 influenza A/H1N1p vaccination campaign. Although approximately 50% of the population was vaccinated, there was a considerable variation in clinic performance and community vaccine coverage. OBJECTIVE:To identify comm...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12227

    authors: Charland KM,de Montigny L,Brownstein JS,Buckeridge DL

    更新日期:2014-05-01 00:00:00

  • Containing influenza outbreaks with antiviral use in long-term care facilities in Taiwan, 2008-2014.

    abstract:BACKGROUNDS:Influenza can spread rapidly in long-term care facilities (LTCFs), and residents are usually at higher risk for influenza infections. OBJECTIVE:Our study aimed to evaluate the effectiveness of antiviral interventions on outbreak control. METHODS:Taiwan Centers for Disease Control used a syndromic surveill...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12536

    authors: Cheng HY,Chen WC,Chou YJ,Huang AS,Huang WT

    更新日期:2018-03-01 00:00:00

  • Molecular genetic characteristics of influenza A virus clinically isolated during 2011-2016 influenza seasons in Korea.

    abstract:BACKGROUND:The influenza virus is reportedly associated with 3-5 million cases of severe illness and 250 000-500 000 deaths annually worldwide. OBJECTIVES:We investigated the variation of influenza A virus in Korea and examined the association with death. METHODS:A total of 13 620 cases were enrolled in the Hospital-...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12549

    authors: Lee HS,Noh JY,Song JY,Cheong HJ,Choi WS,Jeong HW,Wie SH,Kim WJ

    更新日期:2018-07-01 00:00:00