Abstract:
:Systematic reviews and meta-analyses confirm that influenza vaccination reduces the risk of influenza illness by between about 40% and 60% in seasons when circulating influenza stains are well matched to vaccine strains. Influenza vaccine effectiveness (IVE) estimates, however, are often discordant and a source of confusion for decision makers. IVE assessments are increasingly publicized and are often used by policy makers to make decisions about the value of seasonal influenza vaccination. But there is limited guidance on how IVE should be interpreted or used to inform policy. There are several limitations to the use of IVE for decision-making: (a) IVE studies have methodological issues that often complicate the interpretation of their value; and (b) the full impact of vaccination will almost always be greater than the impact assessed by a point estimate of IVE in specific populations or settings. Understanding the strengths and weaknesses of study methodologies and the fundamental limitations of IVE estimates is important for the accuracy of interpretations and support of policy makers' decisions. Here, we review a comprehensive set of issues that need to be considered when interpreting IVE and determining the full benefits of influenza vaccination. We propose that published IVE values should be assessed using an evaluative framework that includes influenza-specific outcomes, types of VE study design, and confounders, among other factors. Better interpretation of IVE will improve the broader assessment of the value of influenza vaccination and ultimately optimize the public health benefits in seasonal influenza vaccination.
journal_name
Influenza Other Respir Virusesjournal_title
Influenza and other respiratory virusesauthors
Hollingsworth R,El Guerche-Séblain C,Tsai T,Vasiliev Y,Lee S,Bright H,Barbosa Pdoi
10.1111/irv.12786subject
Has Abstractpub_date
2021-01-01 00:00:00pages
164-174issue
1eissn
1750-2640issn
1750-2659journal_volume
15pub_type
杂志文章,评审abstract:OBJECTIVES:To determined the pathogen-specific incidence of respiratory virus infection in Hutterite communities occurring over the 2008-2009 influenza season and assess temporal characteristics of respiratory illness related to infection. METHODS:3273 participants community members enrolled in a cluster randomized tr...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章,随机对照试验
doi:10.1111/irv.12021
更新日期:2013-11-01 00:00:00
abstract:CONTEXT:Preventing nosocomial transmission of influenza is essential to reduce the morbidity and mortality associated with this infection. In October 2009, an outbreak of the 2009 influenza A (H1N1) virus occurred in a hematology ward of a children's hospital over a 21-day period and involved two patients and four heal...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2011.00322.x
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Respiratory syncytial virus (RSV) is a leading etiological agent of acute respiratory tract infections and hospitalizations in children. However, little information is available regarding RSV infections in Latin American countries, particularly among adult patients. OBJECTIVE:To describe the epidemiology of...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12414
更新日期:2017-01-01 00:00:00
abstract::The emergence of a novel swine-origin pandemic influenza virus in 2009, together with the continuing circulation of highly pathogenic avian H5N1 viruses and the urgent global need to produce effective vaccines against such public health threats, has prompted a renewed interest in improving our understanding of the imm...
journal_title:Influenza and other respiratory viruses
pub_type:
doi:10.1111/j.1750-2659.2011.00242.x
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:It has been suggested that live attenuated influenza vaccine (LAIV) may be less effective in older individuals because of prior wild-type influenza infections. LAIV is currently approved in the United States, South Korea and Hong Kong for individuals 2-49 years of age. OBJECTIVE:To examine data from previou...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章,meta分析
doi:10.1111/j.1750-2659.2009.00124.x
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Whether morbidity from the 1918-19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue, the recent literature has hypothesized that morbidity was "socially neutral." OBJECTIVES:To study the associations between influenz...
journal_title:Influenza and other respiratory viruses
pub_type: 历史文章,杂志文章
doi:10.1111/irv.12541
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Highly pathogenic avian influenza A/H5N1 virus remains a potential pandemic threat, and it is essential to continue vaccine development against this subtype. A local mucosal immune response in the upper respiratory tract may stop influenza transmission. It is therefore important to develop effective intranas...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12056
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Influenza-associated myositis (IAM), characterized by severe lower-extremity myalgia and reluctance to walk, is a complication of influenza among children. We investigated IAM in Nebraska during six influenza seasons, 2001-2007. METHODS:During 2006-2007, we requested reports of severe influenza illness among...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2009.00102.x
更新日期:2009-11-01 00:00:00
abstract::The aim of this review was to identify factors predicting actual or intended adherence to antivirals as treatment or prophylaxis for influenza. Literature from inception to March 2015 was systematically reviewed to find studies reporting predictors of adherence to antivirals and self-reported reasons for non-adherence...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章,评审
doi:10.1111/irv.12406
更新日期:2016-11-01 00:00:00
abstract:INTRODUCTION:Literature on influenza focuses on influenza A, despite influenza B having a large public health impact. The Global Influenza B Study aims to collect information on global epidemiology and burden of disease of influenza B since 2000. METHODS:Twenty-six countries in the Southern (n = 5) and Northern (n = 7...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12319
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Limited data exist on transmission dynamics and effectiveness of control measures for influenza in confined settings. OBJECTIVES:To investigate the transmission dynamics of a 2009 pandemic H1N1 influenza A outbreak aboard a Peruvian Navy ship and quantify the effectiveness of the implemented control measure...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12240
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Fever and respiratory symptoms are the major causes of hospitalisation in infants aged 90 days or less. Respiratory viruses (RVs) are detected by multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) in up to 70% of infants tested in this population. Aminotransferase elevation is not uncommon i...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12732
更新日期:2020-07-01 00:00:00
abstract::Antiviral drugs continue to be an important option for the treatment of influenza disease and will likely be the only option during the early phases of pandemic. However, the limited number of drug classes licensed for treatment of influenza raises several issues, particularly in the face of drug resistance. Two class...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12049
更新日期:2013-01-01 00:00:00
abstract::Enterovirus 68 (EV68) infection occasionally manifests with fatal outcomes. However, detection of EV68 in serum and its clinical outcomes are yet to be determined. In this study, we retrospectively tested stored serum samples collected from pediatric pneumonia patients whose nasopharyngeal specimens were positive for ...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12206
更新日期:2014-01-01 00:00:00
abstract::In this report, we describe the occurrence of two novel swine influenza viruses (SIVs) in pigs in Argentina. These viruses are the result of two independent reassortment events between the H1N1 pandemic influenza virus (H1N1pdm) and human-like SIVs, showing the constant evolution of influenza viruses at the human-swin...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2011.00246.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Given their medical vulnerabilities, we investigated the epidemiological factors related to H1N1 infection in school-aged children. METHODS:This study analyzed data collected on 7448 school-aged children in South Korea between 18 November and 8 December 2009. RESULTS:We found that H1N1 infection was associa...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2011.00318.x
更新日期:2012-09-01 00:00:00
abstract::A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole-genome sequencing of 77 influenza A(H1N1)pdm0...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12389
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:A candidate pandemic influenza H5N1 vaccine should provide rapid and long-lasting immunity against antigenically drifted viruses. As H5N1 viruses are poorly immunogenic, this may require a combination of immune potentiating strategies. An attractive approach is combining the intrinsic immunogenicity of viros...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2011.00256.x
更新日期:2011-11-01 00:00:00
abstract::Highly pathogenic avian influenza A H5N1 viruses remain a significant health threat to humans given the continued rare occurrence of human cases with a high case fatality rate. This brief literature review summarizes available evidence of risk factors for H5N1 infection in humans and updates a recent systematic review...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章,评审
doi:10.1111/irv.12077
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In this study we investigated the levels of cytokines and chemokines produced locally and systemically after influenza vaccination of patients undergoing tonsillectomy. METHODS:Blood and saliva were collected prior to, and 1 or 2 weeks after vaccination at the time of the tonsillectomy. The cy...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2007.00019.x
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:The new influenza virus A/H1N1 (2009), identified in mid-2009, rapidly spread over the world. Estimating the transmissibility of this new virus was a public health priority. METHODS:We reviewed all studies presenting estimates of the serial interval or generation time and the reproduction number of the A/H1...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章,评审
doi:10.1111/j.1750-2659.2011.00234.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVES:Knowledge of the secondary attack rate (SAR) and serial interval (SI) of influenza is important for assessing the severity of seasonal epidemics of the virus. To date, such estimates have required extensive surveys of target populations. Here, we propose a method for estimating the intrafamily SAR and SI fro...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12321
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:A diversifying pool of mammalian-adapted influenza A viruses (IAV) with largely unknown zoonotic potential is maintained in domestic swine populations worldwide. The most recent human influenza pandemic in 2009 was caused by a virus with genes originating from IAV isolated from swine. Swine influenza viruses...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12407
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Molecular testing for viral pathogens has resulted in increasing detection of multiple viruses in respiratory secretions of ill children. The clinical impact of multiple virus infections on clinical presentation and outcome is unclear. OBJECTIVES:To compare clinical characteristics and viral load between ch...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2011.00265.x
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:During April-July 2009, U.S. hospitalization rates for 2009 pandemic influenza A (H1N1) virus (H1N1pdm09) infection were estimated at 4·5/100 000 persons. We describe rates and risk factors for H1N1pdm09 infection among American Indians (AIs) in four isolated southwestern U.S. communities served by the India...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12123
更新日期:2013-11-01 00:00:00
abstract::The aim of this study was to investigate the rate of transmission of respiratory viral infections to children visiting the emergency room of a large pediatric hospital during winter. A total of 615 children were prospectively studied. Twenty-two (3·6%) children developed at least one symptom compatible with a respirat...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2012.00355.x
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:In Ireland, horses may be protected against equine influenza virus (EIV) as a result of natural exposure or vaccination. Current mandatory vaccination programmes are targeted at highly mobile horses. A correlation between antibody levels as measured by single radial haemolysis (SRH) and protective immunity a...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/j.1750-2659.2010.00163.x
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Nineteen mass vaccination clinics were established in Montreal, Canada, as part of the 2009 influenza A/H1N1p vaccination campaign. Although approximately 50% of the population was vaccinated, there was a considerable variation in clinic performance and community vaccine coverage. OBJECTIVE:To identify comm...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12227
更新日期:2014-05-01 00:00:00
abstract:BACKGROUNDS:Influenza can spread rapidly in long-term care facilities (LTCFs), and residents are usually at higher risk for influenza infections. OBJECTIVE:Our study aimed to evaluate the effectiveness of antiviral interventions on outbreak control. METHODS:Taiwan Centers for Disease Control used a syndromic surveill...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12536
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The influenza virus is reportedly associated with 3-5 million cases of severe illness and 250 000-500 000 deaths annually worldwide. OBJECTIVES:We investigated the variation of influenza A virus in Korea and examined the association with death. METHODS:A total of 13 620 cases were enrolled in the Hospital-...
journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12549
更新日期:2018-07-01 00:00:00