Abstract:
:As the most important viral cause of severe respiratory disease in infants and increasing recognition as important in the elderly and immunocompromised, respiratory syncytial virus (RSV) is responsible for a massive health burden worldwide. Prophylactic antibodies were successfully developed against RSV. However, their use is restricted to a small group of infants considered at high risk of severe RSV disease. There is still no specific therapeutics or vaccines to combat RSV. As such, it remains a major unmet medical need for most individuals. The World Health Organisations International Clinical Trials Registry Platform (WHO ICTRP) and PubMed were used to identify and review all RSV vaccine, prophylactic and therapeutic candidates currently in clinical trials. This review presents an expert commentary on all RSV-specific prophylactic and therapeutic candidates that have entered clinical trials since 2008.
journal_name
Influenza Other Respir Virusesjournal_title
Influenza and other respiratory virusesauthors
Broadbent L,Groves H,Shields MD,Power UFdoi
10.1111/irv.12313subject
Has Abstractpub_date
2015-07-01 00:00:00pages
169-78issue
4eissn
1750-2640issn
1750-2659journal_volume
9pub_type
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journal_title:Influenza and other respiratory viruses
pub_type: 历史文章,杂志文章
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journal_title:Influenza and other respiratory viruses
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Influenza and other respiratory viruses
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pub_type: 杂志文章
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